El Bairi, Khalid https://orcid.org/0000-0002-8414-4145
Haynes, Harry R.
Blackley, Elizabeth
Fineberg, Susan
Shear, Jeffrey
Turner, Sophia
de Freitas, Juliana Ribeiro https://orcid.org/0000-0003-4978-7273
Sur, Daniel https://orcid.org/0000-0002-0926-4614
Amendola, Luis Claudio https://orcid.org/0000-0002-6404-450X
Gharib, Masoumeh
Kallala, Amine
Arun, Indu
Azmoudeh-Ardalan, Farid https://orcid.org/0000-0003-4701-0532
Fujimoto, Luciana
Sua, Luz F.
Liu, Shi-Wei
Lien, Huang-Chun
Kirtani, Pawan https://orcid.org/0000-0002-2343-7016
Balancin, Marcelo
El Attar, Hicham
Guleria, Prerna
Yang, Wenxian https://orcid.org/0000-0002-5349-9680
Shash, Emad
Chen, I-Chun
Bautista, Veronica
Do Prado Moura, Jose Fernando
Rapoport, Bernardo L.
Castaneda, Carlos
Spengler, Eunice
Acosta-Haab, Gabriela
Frahm, Isabel
Sanchez, Joselyn
Castillo, Miluska https://orcid.org/0000-0002-0111-3176
Bouchmaa, Najat
Md Zin, Reena R.
Shui, Ruohong
Onyuma, Timothy
Yang, Wentao
Husain, Zaheed
Willard-Gallo, Karen
Coosemans, An
Perez, Edith A.
Provenzano, Elena https://orcid.org/0000-0003-3345-3965
Ericsson, Paula Gonzalez
Richardet, Eduardo
Mehrotra, Ravi https://orcid.org/0000-0001-9453-1408
Sarancone, Sandra
Ehinger, Anna https://orcid.org/0000-0001-9225-7396
Rimm, David L. https://orcid.org/0000-0001-5820-4397
Bartlett, John M. S. https://orcid.org/0000-0002-0347-3888
Viale, Giuseppe
Denkert, Carsten https://orcid.org/0000-0002-2249-0982
Hida, Akira I. https://orcid.org/0000-0002-4486-8819
Sotiriou, Christos https://orcid.org/0000-0002-5745-9977
Loibl, Sibylle
Hewitt, Stephen M. https://orcid.org/0000-0001-8283-1788
Badve, Sunil https://orcid.org/0000-0001-8861-9980
Symmans, William Fraser https://orcid.org/0000-0002-1526-184X
Kim, Rim S.
Pruneri, Giancarlo
Goel, Shom https://orcid.org/0000-0001-8329-9084
Francis, Prudence A. https://orcid.org/0000-0002-7207-9286
Inurrigarro, Gloria
Yamaguchi, Rin
Garcia-Rivello, Hernan
Horlings, Hugo https://orcid.org/0000-0003-4782-8828
Afqir, Said
Salgado, Roberto https://orcid.org/0000-0002-1110-3801
Adams, Sylvia
Kok, Marleen
Dieci, Maria Vittoria
Michiels, Stefan
Demaria, Sandra https://orcid.org/0000-0003-4426-0499
Loi, Sherene https://orcid.org/0000-0001-6137-9171
,
El Bairi, Khalid
Haynes, Harry R.
Blackley, Elizabeth
Fineberg, Susan
Shear, Jeffrey
Turner, Sophia
de Freitas, Juliana Ribeiro
Sur, Daniel
Amendola, Luis Claudio
Gharib, Masoumeh
Kallala, Amine
Arun, Indu
Azmoudeh-Ardalan, Farid
Fujimoto, Luciana
Sua, Luz F.
Liu, Shi-Wei
Lien, Huang-Chun
Kirtani, Pawan
Balancin, Marcelo
El Attar, Hicham
Guleria, Prerna
Yang, Wenxian
Shash, Emad
Chen, I-Chun
Bautista, Veronica
Do Prado Moura, Jose Fernando
Rapoport, Bernardo L.
Castaneda, Carlos
Spengler, Eunice
Acosta-Haab, Gabriela
Frahm, Isabel
Sanchez, Joselyn
Castillo, Miluska
Bouchmaa, Najat
Md Zin, Reena R.
Shui, Ruohong
Onyuma, Timothy
Yang, Wentao
Husain, Zaheed
Willard-Gallo, Karen
Coosemans, An
Perez, Edith A.
Provenzano, Elena
Ericsson, Paula Gonzalez
Richardet, Eduardo
Mehrotra, Ravi
Sarancone, Sandra
Ehinger, Anna
Rimm, David L.
Bartlett, John M. S.
Viale, Giuseppe
Denkert, Carsten
Hida, Akira I.
Sotiriou, Christos
Loibl, Sibylle
Hewitt, Stephen M.
Badve, Sunil
Symmans, William Fraser
Kim, Rim S.
Pruneri, Giancarlo
Goel, Shom
Francis, Prudence A.
Inurrigarro, Gloria
Yamaguchi, Rin
Garcia-Rivello, Hernan
Horlings, Hugo
Afqir, Said
Salgado, Roberto
Adams, Sylvia
Kok, Marleen
Dieci, Maria Vittoria
Michiels, Stefan
Demaria, Sandra
Loi, Sherene
Schelfhout, Vera
Arbzadeh, Elham
Bondanar, Anastasiya
Reyes, Silvio Antonio Galeano
Ruz, Jose Ramirez
Kang, Jun
Xiang, Lu
Zimovjanova, Martina
Togores, Pilar
Ozturk, Tulin
Patil, Asawari
Corpa, Marcus
Whitehouse, Ann
Tan, Benjamin
de Paula, Alfredo
Rossetti, Claudia
Lang-Schwarz, Corinna
Mahon, Sarah
Giacometti, Cinzia
Linderholm, Barbro
Deman, Frederik
Montagna, Giacomo
Gong, Gyungyub
Pavcovich, Marta
Chaer, Yeesoo
Cabrero, Isabel Alvarado
de Brito, Mayana Lopes
Ilieva, Nevena
Fulop, Annamaria
Souza, Maiara
Bilancia, Domenico
Idowu, Michael
Johri, Ritika
Szpor, Joanna
Bachani, Lira
Schmitt, Fernando
Giannotti, Mag
Kurebayashi, Yutaka
Ramirez, Bruno Elias Anota
Salido, Eduardo
Bortesi, Laura
Bonetto, Sara
Elomina, Kevin
Lopez, Patricia
Sharma, Vijay
Edirisinghe, Amalika
Mathur, Dhanvi
Sahay, Ayushi
Mouloud, Makhlouf Ait
Giang, Chau Huynh
Mukolwe, Edwin
Kiruka, Edgar
Samberg, Nancy
Abe, Norie
Brown, Mark
Millar, Ewan
Li, Xiaoxian
Yuan, Zheng
Pasupathy, Asokan
Miele, Raffaele
Luff, Ronald
e Porfirio, Monica Modesto Araujo
Ajemba, Ogugua
Soni, Rashida
Orvieto, Enrico
DiMaio, Michael
Thomas, Jeremy
Merard, Reena
Subramaniam, Manish Mani
Apolinario, Thiago
Preda, Ovidiu
Preda, Ricardo
Makanga, Alexander
Maior, Marcelo Souto
Li, Lingyu
Saghatchian, Mahasti
Saurine, Tricia
Janssen, Emiel
Cochran, John
Vlada, Nikitina
Cappellesso, Rocco
Elfer, Katherine
Hollick, Morven
Desai, Sangeeta
Oner, Gizem
Schreurs, Arthur
Liu, Steve
Perera, Rashindrie
Mercurio, Paola
Garcia, Felip
Hosny, Kareem
Matsumoto, Hirofumi
van Deurzen, Carolien
Bianchini, Giampaolo
Coban, Ipek
Jahangir, Arif
Rahman, Arman
Stover, Daniel
Luz, Paulo
Martel, Anne
Waumans, Yannick
Stenzinger, Albrecht
Cortes, Javier
Dimitrova, Polina
Nauwelaers, Inne
Velasco, Montse
Fan, Fang
Akturk, Guray
Firer, Michael
Roxanis, Ioannis
Schneck, Mary
Wen, Hannah
Cockenpot, Vincent
Konstantinov, Aleksei
Calatrava, Ana
Vidya, M. N.
Choi, Hyun Joo
Jank, Paul
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Sabanathan, Dhanusha
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Hoeflmayer, Doris
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Grigoriadis, Anita
Porcellato, Ilaria
Acs, Balazs
Miglietta, Federica
Parrodi, Jeannette
Clunie, David
Calhoun, Benjamin
Lu, Fang-I
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Tabbarah, Sami
Tran, William
Garcia-murillas, Isaac
Jelinic, Petar
Boeckx, Carolien
Souza, Sandra
Cebollero, MarÇða
Felip, Eudald
Rendon, Jose Luis Solorzano
El Gabry, Ehab
Saltz, Joel
Bria, Emilio
Garufi, Giovanna
Hartman, Johan
Sebastian, Manu
Olofsson, Helena
Kooreman, Loes
Cucherousset, Joël
Mathieu, Marie-Christine
Ballesteros-Merino, Carmen
Siziopikou, Popi
Fong, Jacinta
Klein, Molly
Qulis, Ignasi Roig I.
Wesseling, Jelle
Bellolio, Enrique
Araya, Juan Carlos
Naber, Stephen
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Castellano, Isabella
Ales, Ales
Laenkholm, Anne-Vibeke
Kulka, Janina
Quinn, Cecily
Sapino, Anna
Amendoeira, Isabel
Marchio, Caterina
Braybrooke, Jeremy
Vincent-Salomon, Anne
Korski, Konstanty
Sofopoulos, Michail
Stovgaard, Elisabeth Ida Specht
Bianchi, Simonetta
Bago-Horvath, Zsuzsanna
Yu, Clare
Regitnig, Peter
Hall, Sean
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Sant, Sneha
Tille, Jean-Christophe
Gallas, Brandon
Bethmann, Daniel
Savas, Peter
Mendes, Larissa
Soler, Teresa
van Seijen, Maartje
Gruosso, Tina
Quintana, Angela
Giltnane, Jennifer
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Duregon, Eleonora
de Cabo, Rafa
Recamo, Phil Coates
Gaboury, Louis
Zimmerman, Johannes
Pop, Claudia Stanciu
Wernicke, Alejandra
Williams, David
Gill, Anthony
Solomon, Benjamin
Thapa, Bibhusal
Farshid, Gelareh
Gilham, Leslie
Christie, Michael
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Hendry, Shona
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Lakhani, Sunil R.
Fuchs, Talia
John, Tom
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Ignatiadis, Michail
Van Bockstal, Mieke
Sirtaine, Nicolas
Vermeulen, Peter
de Wind, Roland
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Almangush, Alhadi
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de Maaker, Michiel
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al Bakir, Maise
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Kim, Seong-Rim
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Paik, Soonmyung
Schnitt, Stuart
d’Alfons, Timothy
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Tong, Weida
Wang, Yihong
Dos Anjos, Carlos Henrique
Gaire, Fabien
Van Diest, Paul J.
Article History
Received: 3 November 2020
Accepted: 28 September 2021
First Online: 1 December 2021
Competing interests
: S. Loi has received research funding to her institution from Novartis, Bristol Meyers Squibb, Merck, Roche-Genentech, Puma Biotechnology, Pfizer, Eli Lilly, Nektar Therapeutics AstraZeneca, and Seattle Genetics. S. Loi has acted as a consultant (not compensated) to Seattle Genetics, Pfizer, Novartis, BMS, Merck, AstraZeneca, and Roche-Genentech. S. Loi has acted as a consultant (paid to her institution) to Aduro Biotech, Novartis, GlaxoSmithKline, Roche-Genentech, Puma Biotechnology, AstraZeneca, and G1 Therapeutics. S. Loi is a Scientific Advisory Board Member of Akamara Therapeutics. S.D. has received research funding from institutions from Lytix Biopharma and Nanobiotix is a scientific advisory board member of Lytix Biopharma and has acted as an ad-hoc consultant (compensated) to Ono Pharma USA Inc, EMD Serono, and Mersana Therapeutics. S.G. is the recipient of lab research funding from Eli Lilly and Co and G1 Therapeutics. Shom Goel has served as a paid advisory board member for Eli Lilly and Co, G1 Therapeutics, Pfizer, and Novartis. S.G. also conducts clinical research sponsored by Eli Lilly and Co. S. Loibl reports grants and others from Abbvie, grants and other from Amgen, grants and other from Celgene, grants and other from Novartis, grants and other from Roche, other from Seattle Genetics, other from PriME/Medscape, personal fees from Chugai, grants and other from Daiichi-Sankyo, other from Lilly, other from Samsung, other from BMS, other from Puma, other from MSD, grants from Immunomedics, grants and other from AstraZeneca, grants and other from Pfizer, other from Pierre Fabre and other from Merck outside the submitted work; In addition, Dr. Loibl has a patent EP14153692.0 pending. J.M.S.B. BSc, PhD, FRCPath has consultancies for Insight Genetics, Inc. BioNTech AG Biotheranostics, Inc. Pfizer RNA Diagnostics Inc. oncoXchange/MedcomXchange Communications Inc. Herbert Smith French Solicitors OncoCyte Corporation SCIENTIFIC ADVISORY BOARD MedcomXchange Communications Inc. HONORARIA NanoString Technologies, Inc. Oncology Education Biotheranostics, Inc. MedcomXchange Communications Inc. RESEARCH FUNDING Thermo Fisher Scientific GenoptixAgendiaNanoString Technologies, Inc. Stratifyer GmbH Biotheranostics, Inc. TRAVEL, ACCOMMODATIONS, EXPENSES Biotheranostics, Inc. NanoString Technologies, Inc. Breast Cancer Society of Canada PATENTS—APPLIED Jan 2017: Methods and Devices for Predicting Anthracycline Treatment Efficacy, US utility—15/325,472; EPO—15822898.1; Canada—not yet assigned Jan 2017: Systems, Devices and Methods for Constructing and Using a Biomarker, US utility—15/328,108; EPO—15824751.0; Canada—not yet assigned Oct 2016: Histone gene module predicts anthracycline benefit, PCT/CA2016/000247 Dec 2016: 95-Gene Signature of Residual Risk Following Endocrine Treatment, PCT/CA2016/000304 Dec 2016: Immune Gene Signature Predicts Anthracycline Benefit, PCT/CA2016/000305 June 2020: Use of Molecular Classifiers to Diagnose, Treat and Prognose Prostate Cancer, US Provisional 63/040.692 INVENTION DISCLOSURE Disclosure Name: A Molecular Classifier for Personalized Risk Stratification for Patients with Prostate Cancer, Date: 21/08/2019. P.A.F. has received Honoraria from AstraZeneca and Novartis and Traveled to give overseas lectures from Ipsen. B.L.R. reports non-financial support from HalioDx, in the form of a collaborative association on a non-remunerative basis, during the conduct of the study. D.R. reports grants and personal fees from Amgen and AstraZeneca, Cepheid, Konica Minolta InVicro, NextCure, Ultivue, and Eli Lilly; personal fees from Bristol Myers Squibb, Cell Signaling Technology, Daiichi Sankyo, Danaher, GSK, Merck, Nanostring Technologies, Odonate, Paige. AI, Roche, Sanofi, and Ventana; grants from Navigate Biopharma; and personal royalties from RareCyte related to a patent on circulating cancer cells outside of the submitted work. A.E. is a Roche advisory board and Lecturer paid by Roche, Amgen, and Novartis. M.V.D. has personal fees for advisory/consultancy roles from Eli Lilly, Celgene, Novartis, and Genomic Health. R.Y. has received support from Chugai pharmaceutical company. S.M. has conflicts of interest not related to this study including statistical advice for IDDI and Janssen Cilag and is an Independent Data Monitoring Committee member for Hexal, Steba, IQVIA, Roche, Sensorion, Biophytis, Servier, and Yuan. M.K. Institution receives funding from BMS, Roche, AZ/Medimmune. M.K. has an advisory role for BMS, Roche, MSD, and Daiichi. R.S. reports non-financial support from Merck and Bristol Myers Squibb; research support from Merck, Puma Biotechnology, and Roche; and personal fees from Roche for an advisory board related to a trial-research project. The remaining authors declare no competing interests.