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Article History

Received: 19 January 2022

Accepted: 1 July 2022

First Online: 20 July 2022

Competing interests

: The authors have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. Elisa Agostinetto: Consultancy/honoraria from Eli Lilly, Sandoz. Support to attend medical conferences (travel accommodations/expenses) from Novartis, Roche, Eli Lilly, Genetic, Istituto Gentili (outside the submitted work). Samuel Martel: Honoraria and advisory board for Novartis, Pfizer, Knight Therapeutics, Exact Science, Taiho, Apobiologix (outside the submitted work). Philippe Aftimos: Consulting: Boehringer Ingelheim, Macrogenics, Roche, Novartis, Amcure, Servier, G1 Therapeutics, Radius, Deloitte, Menarini; Honoraria: Synthon, Amgen, Novartis, Gilead; Travel grants: Amgen, MSD, Pfizer, Roche; Research funding to my institution: Roche (outside the submitted work). Noam Pondé: Honoraria and advisory board for Lilly, Novartis, Roche/Genentech, AstraZeneca and Pfizer (outside the submitted work). Christian Maurer: Travel grants: Mundipharma, Amgen, Servier Deutschland GmbH, Abbvie. Honoraria: Abbvie. Advisory board: Celgene/ BMS and Pfizer (outside the submitted work). Sarra El-Abed: grants from Novartis during the conduct of the ALTTO study, and grants from Roche/Genentech and Pfizer (outside of the submitted work). Yingbo Wang: Employee of Novartis Pharmaceuticals and holds stock in the company (outside the submitted work). Saranya Chumsri: Research funding from Merck and Pfizer (outside the submitted work). Judith Bliss: Research Funding to her Institution: AstraZeneca, Merck Sharp & Dohme, Medivation, Puma Biotechnology, Clovis Oncology, Pfizer, Janssen-Cilag, Roche, Novartis (previously GSK), Eli Lilly (outside the submitted work). Judith Kroep: Honoraria and advisory board: AstraZeneca, Daiichi Sankyo, Eisai, Lilly, MSD, Novartis, Pfizer, GSK. Research grant: Amgen, Astra Zeneca, Novartis, Philips (outside the submitted work). Marco Colleoni: Research grant to his Institution: Roche (outside the submitted work). Lucia Del Mastro: Honoraria: Roche, Novartis, Eli Lilly, MSD, Pfizer, Ipsen. Honoraria to her Institution: Novartis. Consulting or Advisory role: Roche, Eli Lilly, Novartis, MSD, Genomic Health, Pierre Fabre, Daiichi Sankyo, Seagen, Astrazeneca, Eisai, Gilead, Exact Science. Travel, accomodation, expenses: Celgene, Roche, Pfizer, Daiichi Sankyo (outside the submitted work). Alvaro Moreno Aspitia: Institutional research funding from GlaxoSmithKline, Genentech, Daiichi Sankyo, Novartis, Merck, Pfizer, AbbVie and Eli Lilly (outside the submitted work). Martine Piccart: Board Member (Scientific Board): Oncolytics. Consultant (honoraria): AstraZeneca, Camel-IDS, Immunomedics, Lilly, Menarini, MSD, Novartis, Odonate, Pfizer, Roche-Genentech, Seattle Genetics, Immutep, Seagen, NBE Therapeutics. Research grants to her Institute: AstraZeneca, Immunomedics, Lilly, Menarini, MSD, Novartis, Pfizer, Radius, Roche-Genentech, Servier, Synthon (outside the submitted work). Evandro de Azambuja: honoraria and advisory board: Roche/GNE, Novartis, Seattle Genetics, Zodiacs, Libbs and Pierre Fabre; travel grants: Roche/GNE, GSK/Novartis. Research grant for his Institute: Roche/GNE, AstraZeneca, Novartis, and Servier (outside the submitted work). Matteo Lambertini acted as a consultant for Roche, Lilly, AstraZeneca, Exact Sciences, Seagen, Gilead, Pfizer, MSD and Novartis, and received honoraria from Sandoz, Takeda, Roche, Lilly, Pfizer, Ipsen, Libbs, Knight and Novartis (outside the submitted work). Lieveke Ameye, Marianne Paesmans, Malou Vicente, and Fausto Petrelli have no conflict of interests to declare.