Im, Seock-Ah http://orcid.org/0000-0002-5396-6533
Cortes, Javier http://orcid.org/0000-0001-7623-1583
Cescon, David W. http://orcid.org/0000-0002-1080-0998
Yusof, Mastura Md
Iwata, Hiroji
Masuda, Norikazu http://orcid.org/0000-0002-7302-0278
Takano, Toshimi http://orcid.org/0000-0002-8417-5291
Huang, Chiun-Sheng http://orcid.org/0000-0002-6557-211X
Chung, Chi-Feng
Tsugawa, Koichiro
Park, Yeon Hee http://orcid.org/0000-0003-4156-9212
Matsumoto, Koji http://orcid.org/0000-0003-1907-0247
Inoue, Kenichi
Kwong, Ava http://orcid.org/0000-0002-6968-9489
Loi, Sherene http://orcid.org/0000-0001-6137-9171
Fu, Wei
Pan, Wilbur http://orcid.org/0000-0002-9714-6078
Karantza, Vassiliki
Rugo, Hope S. http://orcid.org/0000-0001-6710-4814
Schmid, Peter
Funding for this research was provided by:
Merck Sharp & Dohme LLC, a subsidiary of Merck & Co., Inc., Rahway, NJ, USA
Merck Sharp & Dohme LLC, a subsidiary of Merck & Co., Inc., Rahway, NJ, USA
Merck Sharp & Dohme LLC, a subsidiary of Merck & Co., Inc., Rahway, NJ, USA
Merck Sharp & Dohme LLC, a subsidiary of Merck & Co., Inc., Rahway, NJ, USA
Merck Sharp & Dohme LLC, a subsidiary of Merck & Co., Inc., Rahway, NJ, USA
Merck Sharp & Dohme LLC, a subsidiary of Merck & Co., Inc., Rahway, NJ, USA
Merck Sharp & Dohme LLC, a subsidiary of Merck & Co., Inc., Rahway, NJ, USA
Merck Sharp & Dohme LLC, a subsidiary of Merck & Co., Inc., Rahway, NJ, USA
Merck Sharp & Dohme LLC, a subsidiary of Merck & Co., Inc., Rahway, NJ, USA
Merck Sharp & Dohme LLC, a subsidiary of Merck & Co., Inc., Rahway, NJ, USA
Merck Sharp & Dohme LLC, a subsidiary of Merck & Co., Inc., Rahway, NJ, USA
Merck Sharp & Dohme LLC, a subsidiary of Merck & Co., Inc., Rahway, NJ, USA
Merck Sharp & Dohme LLC, a subsidiary of Merck & Co., Inc., Rahway, NJ, USA
Merck Sharp & Dohme LLC, a subsidiary of Merck & Co., Inc., Rahway, NJ, USA
Merck Sharp & Dohme LLC, a subsidiary of Merck & Co., Inc., Rahway, NJ, USA
Merck Sharp & Dohme LLC, a subsidiary of Merck & Co., Inc., Rahway, NJ, USA
Merck Sharp & Dohme LLC, a subsidiary of Merck & Co., Inc., Rahway, NJ, USA
Merck Sharp & Dohme LLC, a subsidiary of Merck & Co., Inc., Rahway, NJ, USA
Merck Sharp & Dohme LLC, a subsidiary of Merck & Co., Inc., Rahway, NJ, USA
Merck Sharp & Dohme LLC, a subsidiary of Merck & Co., Inc., Rahway, NJ, USA
Article History
Received: 24 January 2024
Accepted: 19 July 2024
First Online: 12 September 2024
Competing interests
: Seock-Ah Im: reports advisory role for AstraZeneca, Daiichi-Sankyo, GSK, Hanmi, Idience, Lilly, Merck Sharp & Dohme LLC, a subsidiary of Merck & Co., Inc., Rahway, NJ, USA (MSD), Novartis, Pfizer, Bertis and Roche; and grants for AstraZeneca, Boryung Pharm, Daewoong Pharm, Daiichi-Sankyo, Eisai, Pfizer, and Roche. Javier Cortes: Consulting/Advisor: Roche, Celgene, Cellestia, AstraZeneca, Seattle Genetics, Daiichi Sankyo, Erytech, Athenex, Polyphor, Lilly, MSD, GSK, Leuko, Bioasis, Clovis Oncology, Boehringer Ingelheim, Ellipses, Hibercell, BioInvent, Gemoab, Gilead, Menarini, Zymeworks, Reveal Genomics, and Expres2ion Biotechnologies. Honoraria: Roche, Novartis, Celgene, Eisai, Pfizer, Samsung Bioepis, Lilly, MSD, Daiichi Sankyo, and AstraZeneca. Research funding to institution: Roche, Ariad Pharmaceuticals, AstraZeneca, Baxalta GMBH/Servier Affaires, Bayer Healthcare, Eisai, F. Hoffman-La Roche, Guardanth Health, MSD, Pfizer, Piqur Therapeutics, Puma C, and Queen Mary University of London. Stock: MedSIR, Nektar Pharmaceuticals, and Leuko (relative). Travel, accommodation, expenses: Roche, Novartis, Eisai, Pfizer, Daiichi Sankyo, AstraZeneca, Gilead, and MSD. Patents: Pharmaceutical Combinations of a Pi3k Inhibitor and a Microtubule Destabilizing Agent.Javier Cortés Castán, Alejandro Piris Giménez, Violeta Serra Elizalde. WO 2014/199294 A. ISSUED; Her2 as a predictor of response to dual HER2 blockade in the absence of cytotoxic therapy.Aleix Prat, Antonio Llombart, Javier Cortés.US 2019/ 0338368 A1. LICENSED. David W. Cescon: Consultancy/Advisory: AstraZeneca, Exact Sciences, Eisai, Gilead, GlaxoSmithKline, Inflex, Inivata/Neogenomics, Lilly, MSD, Novartis, Pfizer, Roche, and SAGA. Research support (to institution): AstraZeneca, GlaxoSmithKline, Inivata, Knight, Merck, Pfizer, and Roche. Member of a trial steering committee: AstraZeneca, Merck, and GlaxoSmithKline. Holds a patent (US62/675,228) for methods of treating cancers characterized by a high expression level of spindle and kinetochore associated complex subunit 3 (ska3) gene. Mastura Md Yusof: Received honoraria from AstraZeneca, Bayer, Boehringer Ingelheim, Merck, MSD, Specialised Therapeutics, Zuellig Pharma, Novartis, Pfizer, Roche, Eisai, Celgene; has received grant funding (to institution) from Astellas, AstraZeneca, Arcus, Genentech, Mundi Pharma, Novartis, Pfizer, Roche. Hiroji Iwata: Honoraria - AstraZeneca; Chugai Pharma; Daiichi Sankyo; Eisai; Kyowa Hakko Kirin; Lilly Japan; Novartis; Pfizer. Consulting or Advisory Role - AstraZeneca; Chugai Pharma; Daiichi Sankyo; Kyowa Hakko Kirin; Lilly Japan; Novartis; Pfizer. Research Funding - AstraZeneca, Bayer, Chugai Pharma, Daiichi Sankyo, Eisai, GlaxoSmithKline, Kyowa Hakko Kirin, Lilly Japan, MSD, Nihonkayaku, Novartis, and Pfizer (all to institution). Norikazu Masuda: Leadership - Japan Breast Cancer Research Group Association (JBCRG). Honoraria - AstraZeneca; Chugai Pharma; Eisai; Lilly Japan; Pfizer. Research Funding – AstraZeneca, Chugai Pharma, Daiichi Sankyo, Eisai, Eli Lilly, Kyowa-Kirin, MSD, Novartis, Pfizer, and Sanofi (all to institution). Toshimi Takano: Lecture fees from Daiichi-Sankyo, Chugai, Kyowa Kirin, Eisai, Pfizer, Eli Lilly, and Celltrion. Research funding from Daiichi-Sankyo, Chugai, Eisai, Ono, and MSD. Chiun-Sheng Huang: Research grants: Aston Sci, AstraZeneca, Daiichi Sankyo, EirGenix, Eli Lilly, Gilead, MSD, Novartis, OBI Pharma, Pfizer, Roche, and Seagen. Honoraria: AstraZeneca, Daiichi Sankyo, Eli Lilly, Novartis, Pfizer, and Roche. Advisory fees: AstraZeneca, Daiichi Sankyo, Eli Lilly, Novartis, Pfizer, and Roche. Chi-Feng Chung: Honoraria: Daiichi Sankyo, Roche, Lotus, EirGenix, AstraZeneca, and Novartis. Koichiro Tsugawa: Honoraria: Pfizer and Kyowa Hakko Kirin. Research funding (to institution): Daiichi Sankyo. Yeon Hee Park: Consultancy or advisory fees: AstraZeneca, Eisai, Eli Lilly Export S.A. Puerto Rico Branch, Novartis, Pfizer, and Roche. Research funding: AstraZeneca, Merck, Novartis, Pfizer, and Roche. Koji Matsumoto: Honoraria: Chugai, Kyowa Hakko Kirin, and MSD. Research funding (to institution): Daiichi Sankyo, Eisai, Gilead Sciences, Lilly Japan, and MSD. Kenichi Inoue: Research funding: AstraZeneca, Chugai Pharma, Daiichi Sankyo, Eisai, Eli Lilly, Kyowa-Kirin, MSD, Novartis, Pfizer, Taiho, Ono, Astellas, and Sanofi (all to institution). Ava Kwong: Honoraria (for giving educational lectures and attending conferences): AstraZeneca, Pfizer, and Stryker Roche. Grant funding (to institution for clinical trials and research): AstraZeneca, Pfizer, MSD (Asia) Limited, and Roche. Sherene Loi: research funding to her institution from Novartis, Bristol-Myers Squibb, Merck, Puma Biotechnology, Eli Lilly, Nektar Therapeutics, Astra Zeneca, and Seattle Genetics. She has acted as consultant (not compensated) to Seattle Genetics, Novartis, Bristol-Myers Squibb, Merck, AstraZeneca, Eli Lilly, Pfizer, Gilead Therapeutics, and Roche-Genentech. She has acted as consultant (paid to her institution) to Aduro Biotech, Novartis, GlaxoSmithKline, Roche-Genentech, Astra Zeneca, Silverback Therapeutics, G1 Therapeutics, PUMA Biotechnologies, Pfizer, Gilead Therapeutics, Seattle Genetics, Daiichi Sankyo, Merck, Amunix, Tallac Therapeutics, Eli Lilly, and Bristol-Myers Squibb. Wei Fu: employee of Merck Sharp & Dohme LLC, a subsidiary of Merck & Co., Inc., Rahway, NJ, USA; owns stock in Merck & Co., Inc., Rahway, NJ, USA. Wilbur Pan: employee of Merck Sharp & Dohme LLC, a subsidiary of Merck & Co., Inc., Rahway, NJ, USA; owns stock in Merck & Co., Inc., Rahway, NJ, USA. Vassiliki Karantza: employee of Merck Sharp & Dohme LLC, a subsidiary of Merck & Co., Inc., Rahway, NJ, USA; owns stock in Merck & Co., Inc., Rahway, NJ, USA. Hope S. Rugo: Research support to institution: Astellas Pharma Inc.; AstraZeneca; Daiichi Sankyo, Inc.; F. Hoffmann-La Roche AG/Genentech, Inc.; Gilead Sciences, Inc.; GlaxoSmithKline; Eli Lilly; Merck & Co., Inc.; Novartis Pharmaceuticals Corporation; OBI Pharma; Pfizer; Pionyr Immunotherapeutics; Sermonix Pharmaceuticals Inc.; Taiho Oncology, Inc., and Veru Inc. Consultancy/advisory support: Puma, NAPO, Blueprint, and Scorpion Therapeutics. Peter Schmid: has been a consultant to/received honoraria from AstraZeneca, Bayer, Boehringer Ingelheim, Merck, Novartis, Pfizer, Puma, Roche, Eisai, and Celgene; has received grant funding (to institution) from Astellas, AstraZeneca, Genentech, Novartis, Oncogenex, Roche, and Medivation.