Graefe, Adam S. L. https://orcid.org/0009-0004-8124-8864
Rehburg, Filip https://orcid.org/0009-0007-0457-5724
Alkarkoukly, Samer https://orcid.org/0000-0003-1891-1366
Danis, Daniel https://orcid.org/0000-0003-0900-3411
Grönke, Ana https://orcid.org/0009-0006-9447-7687
Hübner, Miriam R. https://orcid.org/0000-0001-5160-1242
Bartschke, Alexander https://orcid.org/0000-0002-5849-482X
Debertshäuser, Thomas https://orcid.org/0009-0005-9329-2675
Klopfenstein, Sophie A. I. https://orcid.org/0000-0002-8470-2258
Saß, Julian https://orcid.org/0000-0002-2068-7765
Fleck, Julia https://orcid.org/0000-0003-2766-4547
Rehberg, Mirko https://orcid.org/0000-0001-9534-4102
Zschüntzsch, Jana https://orcid.org/0000-0002-7062-5319
Nyoungui, Elisabeth F. https://orcid.org/0000-0003-4263-4629
Kalashnikova, Tatiana https://orcid.org/0009-0009-3825-144X
Murguía-Favela, Luis https://orcid.org/0000-0001-6893-3366
Derfalvi, Beata https://orcid.org/0000-0001-7272-7119
Wright, Nicola A. M. https://orcid.org/0000-0003-3144-4969
Moosa, Shahida https://orcid.org/0000-0002-4463-3067
Ogishima, Soichi https://orcid.org/0000-0001-8613-2562
Semler, Oliver https://orcid.org/0000-0003-0029-7556
Wiegand, Susanna https://orcid.org/0000-0001-8341-9533
Kühnen, Peter https://orcid.org/0000-0003-0211-176X
Mungall, Christopher J. https://orcid.org/0000-0002-6601-2165
Haendel, Melissa A. https://orcid.org/0000-0001-9114-8737
Robinson, Peter N. https://orcid.org/0000-0002-0736-9199
Thun, Sylvia https://orcid.org/0000-0002-3346-6806
Beyan, Oya https://orcid.org/0000-0001-7611-3501
Funding for this research was provided by:
German Federal Ministry of Education and Research (BMBF; FKZ 01KX2121, BMBF; FKZ 01KX2121)
German Research Foundation (DFG FOR 2722; ref. SE2373/1-2; project 384170921, DFG FOR 2722; ref. SE2373/1-2; project 384170921)
Barb Ibbotson Chair in Pediatric Hematology at the Alberta Children’s Hospital Foundation
Immunodeficiency Canada
South African Medical Research Council’s Division of Research Capacity Development under the Early Investigators’ Programme, funded by the South African National Treasury
U.S. National Institutes of Health, National Human Genome Research Institute (grant 7RM1HG010860)
U.S. NIH NHGRI (grant 5U24HG011449)
Article History
Received: 10 June 2025
Accepted: 23 October 2025
First Online: 18 November 2025
Competing interests
: M.A.H. is co-founder of Amalya Health. All other authors declare no competing interests or conflicts of interest.