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Targeting HIV Env immunogens to B cell follicles in nonhuman primates through immune complex or protein nanoparticle formulations

Crossref DOI link: https://doi.org/10.1038/s41541-020-00223-1

Published Online: 2020-08-05

Update policy: https://doi.org/10.1007/springer_crossmark_policy

Authors

Martin, Jacob T.

Cottrell, Christopher A. https://orcid.org/0000-0002-3364-3083
Antanasijevic, Aleksandar

Carnathan, Diane G.

Cossette, Benjamin J.

Enemuo, Chiamaka A.

Gebru, Etse H.

Choe, Yury

Viviano, Federico

Fischinger, Stephanie https://orcid.org/0000-0003-2307-3379
Tokatlian, Talar https://orcid.org/0000-0002-1498-4245
Cirelli, Kimberly M.

Ueda, George https://orcid.org/0000-0002-9792-7149
Copps, Jeffrey https://orcid.org/0000-0003-4793-7258
Schiffner, Torben

Menis, Sergey

Alter, Galit https://orcid.org/0000-0002-7680-9215
Schief, William R. https://orcid.org/0000-0002-1120-0150
Crotty, Shane

King, Neil P.

Baker, David

Silvestri, Guido

Ward, Andrew B.

Irvine, Darrell J. https://orcid.org/0000-0002-8637-1405
Funding

Funding for this research was provided by:

U.S. Department of Health & Human Services | National Institutes of Health (UM1AI100663)

U.S. Department of Health & Human Services | National Institutes of Health (AI125068)

U.S. Department of Health & Human Services | National Institutes of Health (P01AI048240)

U.S. Department of Health & Human Services | National Institutes of Health (UM1AI144462)

U.S. Department of Health & Human Services | National Institutes of Health (Al131873)

U.S. Department of Health & Human Services | National Institutes of Health

U.S. Department of Health & Human Services | National Institutes of Health

U.S. Department of Health & Human Services | National Institutes of Health

U.S. Department of Health & Human Services | NIH | National Institute of Allergy and Infectious Diseases (UM1AI100663)

U.S. Department of Health & Human Services | NIH | National Institute of Allergy and Infectious Diseases (UM1AI144462)

U.S. Department of Health & Human Services | NIH | National Institute of Allergy and Infectious Diseases (AI125068)

U.S. Department of Health & Human Services | NIH | National Institute of Allergy and Infectious Diseases (P01AI048240)

U.S. Department of Health & Human Services | NIH | National Institute of Allergy and Infectious Diseases (UM1AI100663)

U.S. Department of Health & Human Services | NIH | National Institute of Allergy and Infectious Diseases (UM1AI144462)

U.S. Department of Health & Human Services | NIH | National Institute of Allergy and Infectious Diseases (UM1AI100663)

U.S. Department of Health & Human Services | NIH | National Institute of Allergy and Infectious Diseases (UM1AI144462)

U.S. Department of Health & Human Services | NIH | National Institute of Allergy and Infectious Diseases (AI125068)

U.S. Department of Health & Human Services | NIH | National Institute of Allergy and Infectious Diseases (UM1AI100663)

U.S. Department of Health & Human Services | NIH | National Institute of Allergy and Infectious Diseases (UM1AI144462)

U.S. Department of Health & Human Services | NIH | National Institute of Allergy and Infectious Diseases (AI125068)

U.S. Department of Health & Human Services | NIH | National Institute of Allergy and Infectious Diseases (P01AI048240)

U.S. Department of Health & Human Services | NIH | National Institute of Allergy and Infectious Diseases (UM1AI100663)

U.S. Department of Health & Human Services | NIH | National Institute of Allergy and Infectious Diseases (UM1AI144462)

U.S. Department of Health & Human Services | NIH | National Institute of Allergy and Infectious Diseases (AI125068)

U.S. Department of Health & Human Services | NIH | National Institute of Allergy and Infectious Diseases (UM1AI100663)

U.S. Department of Health & Human Services | NIH | National Institute of Allergy and Infectious Diseases (UM1AI144462)

U.S. Department of Health & Human Services | NIH | National Institute of Allergy and Infectious Diseases (AI125068)

U.S. Department of Health & Human Services | NIH | National Institute of Allergy and Infectious Diseases (UM1AI100663)

U.S. Department of Health & Human Services | NIH | National Institute of Allergy and Infectious Diseases (UM1AI144462)

U.S. Department of Health & Human Services | NIH | National Institute of Allergy and Infectious Diseases (AI125068)

U.S. Department of Health & Human Services | NIH | National Institute of Allergy and Infectious Diseases (UM1AI100663)

U.S. Department of Health & Human Services | NIH | National Institute of Allergy and Infectious Diseases (UM1AI144462)

U.S. Department of Health & Human Services | NIH | National Institute of Allergy and Infectious Diseases (AI125068)

U.S. Department of Health & Human Services | NIH | National Institute of Allergy and Infectious Diseases (UM1AI100663)

U.S. Department of Health & Human Services | NIH | National Institute of Allergy and Infectious Diseases (UM1AI144462)

U.S. Department of Health & Human Services | NIH | National Institute of Allergy and Infectious Diseases (AI125068)

U.S. Department of Health & Human Services | NIH | National Institute of Allergy and Infectious Diseases (P01AI048240)

U.S. Department of Health & Human Services | NIH | National Institute of Allergy and Infectious Diseases (UM1AI100663)

U.S. Department of Health & Human Services | NIH | National Institute of Allergy and Infectious Diseases (UM1AI144462)

U.S. Department of Health & Human Services | NIH | National Institute of Allergy and Infectious Diseases (AI125068)

U.S. Department of Health & Human Services | NIH | National Institute of Allergy and Infectious Diseases (UM1AI100663)

U.S. Department of Health & Human Services | NIH | National Institute of Allergy and Infectious Diseases (UM1AI144462)

U.S. Department of Health & Human Services | NIH | National Institute of Allergy and Infectious Diseases (UM1AI100663)

U.S. Department of Health & Human Services | NIH | National Institute of Allergy and Infectious Diseases (UM1AI144462)

U.S. Department of Health & Human Services | NIH | National Institute of Allergy and Infectious Diseases (UM1AI100663)

U.S. Department of Health & Human Services | NIH | National Institute of Allergy and Infectious Diseases (UM1AI144462)

U.S. Department of Health & Human Services | NIH | National Institute of Allergy and Infectious Diseases (UM1AI100663)

U.S. Department of Health & Human Services | NIH | National Institute of Allergy and Infectious Diseases (UM1AI144462)

U.S. Department of Health & Human Services | NIH | National Institute of Allergy and Infectious Diseases (AI125068)

U.S. Department of Health & Human Services | NIH | National Institute of Allergy and Infectious Diseases (UM1AI100663)

U.S. Department of Health & Human Services | NIH | National Institute of Allergy and Infectious Diseases (UM1AI144462)

U.S. Department of Health & Human Services | NIH | National Institute of Allergy and Infectious Diseases (AI125068)

U.S. Department of Health & Human Services | NIH | National Institute of Allergy and Infectious Diseases (UM1AI100663)

U.S. Department of Health & Human Services | NIH | National Institute of Allergy and Infectious Diseases (UM1AI144462)

U.S. Department of Health & Human Services | NIH | National Institute of Allergy and Infectious Diseases (UM1AI100663)

U.S. Department of Health & Human Services | NIH | National Institute of Allergy and Infectious Diseases (UM1AI144462)

U.S. Department of Health & Human Services | NIH | National Institute of Allergy and Infectious Diseases

U.S. Department of Health & Human Services | NIH | National Institute of Allergy and Infectious Diseases

U.S. Department of Health & Human Services | NIH | National Institute of Allergy and Infectious Diseases

Ragon Institute of MGH, MIT and Harvard

Howard Hughes Medical Institute

U.S. Department of Health & Human Services | NIH | National Institute of Allergy and Infectious Diseases

U.S. Department of Health & Human Services | NIH | National Institute of Allergy and Infectious Diseases

U.S. Department of Health & Human Services | National Institutes of Health

Achievement Rewards for College Scientists Foundation

U.S. Department of Health & Human Services | NIH | National Institute of Allergy and Infectious Diseases

U.S. Department of Health & Human Services | NIH | National Institute of Allergy and Infectious Diseases

U.S. Department of Health & Human Services | NIH | National Institute of Allergy and Infectious Diseases

U.S. Department of Health & Human Services | NIH | National Institute of Allergy and Infectious Diseases

U.S. Department of Health & Human Services | NIH | National Institute of Allergy and Infectious Diseases

U.S. Department of Health & Human Services | NIH | National Institute of Allergy and Infectious Diseases

U.S. Department of Health & Human Services | NIH | National Institute of Allergy and Infectious Diseases

U.S. Department of Health & Human Services | NIH | National Institute of Allergy and Infectious Diseases

U.S. Department of Health & Human Services | NIH | National Institute of Allergy and Infectious Diseases

U.S. Department of Health & Human Services | NIH | National Institute of Allergy and Infectious Diseases

U.S. Department of Health & Human Services | NIH | National Institute of Allergy and Infectious Diseases

U.S. Department of Health & Human Services | NIH | National Institute of Allergy and Infectious Diseases

U.S. Department of Health & Human Services | NIH | National Institute of Allergy and Infectious Diseases

U.S. Department of Health & Human Services | NIH | National Institute of Allergy and Infectious Diseases

U.S. Department of Health & Human Services | NIH | National Institute of Allergy and Infectious Diseases

U.S. Department of Health & Human Services | NIH | National Institute of Allergy and Infectious Diseases

U.S. Department of Health & Human Services | NIH | National Institute of Allergy and Infectious Diseases

U.S. Department of Health & Human Services | NIH | National Institute of Allergy and Infectious Diseases

U.S. Department of Health & Human Services | NIH | National Institute of Allergy and Infectious Diseases

U.S. Department of Health & Human Services | NIH | National Institute of Allergy and Infectious Diseases

U.S. Department of Health & Human Services | NIH | National Institute of Allergy and Infectious Diseases

U.S. Department of Health & Human Services | NIH | National Institute of Allergy and Infectious Diseases

U.S. Department of Health & Human Services | NIH | National Institute of Allergy and Infectious Diseases

U.S. Department of Health & Human Services | NIH | National Institute of Allergy and Infectious Diseases

U.S. Department of Health & Human Services | NIH | National Institute of Allergy and Infectious Diseases

U.S. Department of Health & Human Services | NIH | National Institute of Allergy and Infectious Diseases

Bill and Melinda Gates Foundation (OPP1156262)

Bill and Melinda Gates Foundation (OPP1156262)

Bill and Melinda Gates Foundation (OPP1156262)

U.S. Department of Health & Human Services | NIH | National Institute of Allergy and Infectious Diseases

U.S. Department of Health & Human Services | NIH | National Institute of Allergy and Infectious Diseases

U.S. Department of Health & Human Services | NIH | National Institute of Allergy and Infectious Diseases

U.S. Department of Health & Human Services | NIH | National Institute of Allergy and Infectious Diseases

U.S. Department of Health & Human Services | NIH | National Institute of Allergy and Infectious Diseases

U.S. Department of Health & Human Services | NIH | National Institute of Allergy and Infectious Diseases

U.S. Department of Health & Human Services | NIH | National Institute of Allergy and Infectious Diseases

U.S. Department of Health & Human Services | NIH | National Institute of Allergy and Infectious Diseases

U.S. Department of Health & Human Services | NIH | National Institute of Allergy and Infectious Diseases

Bill and Melinda Gates Foundation

Bill and Melinda Gates Foundation

U.S. Department of Health & Human Services | NIH | National Institute of Allergy and Infectious Diseases

U.S. Department of Health & Human Services | NIH | National Institute of Allergy and Infectious Diseases

U.S. Department of Health & Human Services | NIH | National Institute of Allergy and Infectious Diseases

U.S. Department of Health & Human Services | NIH | National Institute of Allergy and Infectious Diseases

U.S. Department of Health & Human Services | NIH | National Institute of Allergy and Infectious Diseases

U.S. Department of Health & Human Services | NIH | National Institute of Allergy and Infectious Diseases

U.S. Department of Health & Human Services | NIH | National Institute of Allergy and Infectious Diseases
License Information

Text and Data Mining valid from 2020-08-05

Version of Record valid from 2020-08-05
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Article History

Received: 17 February 2020

Accepted: 11 June 2020

First Online: 5 August 2020

Competing interests

: D.B. and G.U. are inventors on US patent application 62/422,872 titled “Computational design of self-assembling cyclic protein homo-oligomers”. D.B., N.P.K., and G.U. are inventors on US patent application 62/636,757 titled “Method of multivalent antigen presentation on designed protein nanomaterials”. N.P.K. and D.B. are co-founders and shareholders in Icosavax, a company that has licensed these patent applications, and N.P.K. is a member of Icosavax’s Scientific Advisory Board. All other authors declare no competing interests.