Crossmark

Targeting HIV Env immunogens to B cell follicles in nonhuman primates through immune complex or protein nanoparticle formulations

Crossref DOI link: https://doi.org/10.1038/s41541-020-00223-1

Published Online: 2020-08-05

Update policy: https://doi.org/10.1007/springer_crossmark_policy

Authors

Martin, Jacob T.

Cottrell, Christopher A. https://orcid.org/0000-0002-3364-3083
Antanasijevic, Aleksandar

Carnathan, Diane G.

Cossette, Benjamin J.

Enemuo, Chiamaka A.

Gebru, Etse H.

Choe, Yury

Viviano, Federico

Fischinger, Stephanie https://orcid.org/0000-0003-2307-3379
Tokatlian, Talar https://orcid.org/0000-0002-1498-4245
Cirelli, Kimberly M.

Ueda, George https://orcid.org/0000-0002-9792-7149
Copps, Jeffrey https://orcid.org/0000-0003-4793-7258
Schiffner, Torben

Menis, Sergey

Alter, Galit https://orcid.org/0000-0002-7680-9215
Schief, William R. https://orcid.org/0000-0002-1120-0150
Crotty, Shane

King, Neil P.

Baker, David

Silvestri, Guido

Ward, Andrew B.

Irvine, Darrell J. https://orcid.org/0000-0002-8637-1405
Funding

Funding for this research was provided by:

U.S. Department of Health & Human Services | National Institutes of Health (UM1AI100663, AI125068, P01AI048240, UM1AI144462, Al131873)

U.S. Department of Health & Human Services | National Institutes of Health

U.S. Department of Health & Human Services | National Institutes of Health

U.S. Department of Health & Human Services | National Institutes of Health

U.S. Department of Health & Human Services | NIH | National Institute of Allergy and Infectious Diseases (UM1AI100663, UM1AI144462, AI125068, P01AI048240, UM1AI100663, UM1AI144462, UM1AI100663, UM1AI144462, AI125068, UM1AI100663, UM1AI144462, AI125068, P01AI048240, UM1AI100663, UM1AI144462, AI125068, UM1AI100663, UM1AI144462, AI125068, UM1AI100663, UM1AI144462, AI125068, UM1AI100663, UM1AI144462, AI125068, UM1AI100663, UM1AI144462, AI125068, P01AI048240, UM1AI100663, UM1AI144462, AI125068, UM1AI100663, UM1AI144462, UM1AI100663, UM1AI144462, UM1AI100663, UM1AI144462, UM1AI100663, UM1AI144462, AI125068, UM1AI100663, UM1AI144462, AI125068, UM1AI100663, UM1AI144462, UM1AI100663, UM1AI144462)

U.S. Department of Health & Human Services | NIH | National Institute of Allergy and Infectious Diseases

U.S. Department of Health & Human Services | NIH | National Institute of Allergy and Infectious Diseases

U.S. Department of Health & Human Services | NIH | National Institute of Allergy and Infectious Diseases

Ragon Institute of MGH, MIT and Harvard

Howard Hughes Medical Institute

U.S. Department of Health & Human Services | NIH | National Institute of Allergy and Infectious Diseases

U.S. Department of Health & Human Services | NIH | National Institute of Allergy and Infectious Diseases

U.S. Department of Health & Human Services | National Institutes of Health

Achievement Rewards for College Scientists Foundation

U.S. Department of Health & Human Services | NIH | National Institute of Allergy and Infectious Diseases

U.S. Department of Health & Human Services | NIH | National Institute of Allergy and Infectious Diseases

U.S. Department of Health & Human Services | NIH | National Institute of Allergy and Infectious Diseases

U.S. Department of Health & Human Services | NIH | National Institute of Allergy and Infectious Diseases

U.S. Department of Health & Human Services | NIH | National Institute of Allergy and Infectious Diseases

U.S. Department of Health & Human Services | NIH | National Institute of Allergy and Infectious Diseases

U.S. Department of Health & Human Services | NIH | National Institute of Allergy and Infectious Diseases

U.S. Department of Health & Human Services | NIH | National Institute of Allergy and Infectious Diseases

U.S. Department of Health & Human Services | NIH | National Institute of Allergy and Infectious Diseases

U.S. Department of Health & Human Services | NIH | National Institute of Allergy and Infectious Diseases

U.S. Department of Health & Human Services | NIH | National Institute of Allergy and Infectious Diseases

U.S. Department of Health & Human Services | NIH | National Institute of Allergy and Infectious Diseases

U.S. Department of Health & Human Services | NIH | National Institute of Allergy and Infectious Diseases

U.S. Department of Health & Human Services | NIH | National Institute of Allergy and Infectious Diseases

U.S. Department of Health & Human Services | NIH | National Institute of Allergy and Infectious Diseases

U.S. Department of Health & Human Services | NIH | National Institute of Allergy and Infectious Diseases

U.S. Department of Health & Human Services | NIH | National Institute of Allergy and Infectious Diseases

U.S. Department of Health & Human Services | NIH | National Institute of Allergy and Infectious Diseases

U.S. Department of Health & Human Services | NIH | National Institute of Allergy and Infectious Diseases

U.S. Department of Health & Human Services | NIH | National Institute of Allergy and Infectious Diseases

U.S. Department of Health & Human Services | NIH | National Institute of Allergy and Infectious Diseases

U.S. Department of Health & Human Services | NIH | National Institute of Allergy and Infectious Diseases

U.S. Department of Health & Human Services | NIH | National Institute of Allergy and Infectious Diseases

U.S. Department of Health & Human Services | NIH | National Institute of Allergy and Infectious Diseases

U.S. Department of Health & Human Services | NIH | National Institute of Allergy and Infectious Diseases

U.S. Department of Health & Human Services | NIH | National Institute of Allergy and Infectious Diseases

Bill and Melinda Gates Foundation (OPP1156262, OPP1156262, OPP1156262)

U.S. Department of Health & Human Services | NIH | National Institute of Allergy and Infectious Diseases

U.S. Department of Health & Human Services | NIH | National Institute of Allergy and Infectious Diseases

U.S. Department of Health & Human Services | NIH | National Institute of Allergy and Infectious Diseases

U.S. Department of Health & Human Services | NIH | National Institute of Allergy and Infectious Diseases

U.S. Department of Health & Human Services | NIH | National Institute of Allergy and Infectious Diseases

U.S. Department of Health & Human Services | NIH | National Institute of Allergy and Infectious Diseases

U.S. Department of Health & Human Services | NIH | National Institute of Allergy and Infectious Diseases

U.S. Department of Health & Human Services | NIH | National Institute of Allergy and Infectious Diseases

U.S. Department of Health & Human Services | NIH | National Institute of Allergy and Infectious Diseases

Bill and Melinda Gates Foundation

Bill and Melinda Gates Foundation

U.S. Department of Health & Human Services | NIH | National Institute of Allergy and Infectious Diseases

U.S. Department of Health & Human Services | NIH | National Institute of Allergy and Infectious Diseases

U.S. Department of Health & Human Services | NIH | National Institute of Allergy and Infectious Diseases

U.S. Department of Health & Human Services | NIH | National Institute of Allergy and Infectious Diseases

U.S. Department of Health & Human Services | NIH | National Institute of Allergy and Infectious Diseases

U.S. Department of Health & Human Services | NIH | National Institute of Allergy and Infectious Diseases

U.S. Department of Health & Human Services | NIH | National Institute of Allergy and Infectious Diseases
License Information

Text and Data Mining valid from 2020-08-05

Version of Record valid from 2020-08-05
More Information

Article History

Received: 17 February 2020

Accepted: 11 June 2020

First Online: 5 August 2020

Competing interests

: D.B. and G.U. are inventors on US patent application 62/422,872 titled “Computational design of self-assembling cyclic protein homo-oligomers”. D.B., N.P.K., and G.U. are inventors on US patent application 62/636,757 titled “Method of multivalent antigen presentation on designed protein nanomaterials”. N.P.K. and D.B. are co-founders and shareholders in Icosavax, a company that has licensed these patent applications, and N.P.K. is a member of Icosavax’s Scientific Advisory Board. All other authors declare no competing interests.

Document is current

Any future updates will be listed below