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Authors
Whittaker, Madelynn N. https://orcid.org/0000-0002-3382-1134
Testa, Lauren C.
Quigley, Aidan
Brooks, Dominique L.
Grandinette, Sarah A.
Said, Hooda https://orcid.org/0000-0002-2989-0209
Dwivedi, Garima
Jindal, Ishaan https://orcid.org/0000-0001-9568-3964
Volpp, Daphne
Hacker, Julia L. https://orcid.org/0000-0001-5216-5016
Qu, Ping
Wang, Josh Zhiyong
Levine, Michael A. https://orcid.org/0000-0003-0036-7809
Ahrens-Nicklas, Rebecca C.
Li, Qiaoli
Musunuru, Kiran https://orcid.org/0000-0003-3298-0368
Alameh, Mohamad-Gabriel
Peranteau, William H. https://orcid.org/0000-0003-1608-861X
Wang, Xiao https://orcid.org/0000-0001-7502-8292
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Funding
Funding for this research was provided by:
U.S. Department of Health & Human Services | National Institutes of Health (U19-NS132301)
U.S. Department of Health & Human Services | National Institutes of Health (U01-TR005355)
U.S. Department of Health & Human Services | National Institutes of Health (U19-NS132301)
U.S. Department of Health & Human Services | National Institutes of Health (U19-NS132301)
U.S. Department of Health & Human Services | National Institutes of Health (U19-NS132301)
U.S. Department of Health & Human Services | National Institutes of Health (U19-NS132301)
U.S. Department of Health & Human Services | National Institutes of Health (R01-HD110733)
U.S. Department of Health & Human Services | National Institutes of Health (R21-AR084212)
National Science Foundation (Graduate Research Fellowship)
American Heart Association (Predoctoral Fellowship)
American Heart Association (Career Development Award)
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Article History
Received: 25 May 2024
Accepted: 18 September 2025
First Online: 28 October 2025
Competing interests
: M.N.W. is a fellow with Artis Ventures. J.Z.W. is an employee of Agilent Technologies. R.C.A.-N. is an advisor to Latus Bio and AskBio. K.M. is an advisor to and holds equity in Verve Therapeutics and Variant Bio, is an advisor to LEXEO Therapeutics and Capstan Therapeutics, and receives research funding from Nava Therapeutics and Beam Therapeutics. M.-G.A. is an advisor to Afrigen Biologics. X.W. is an advisor to and receives research funding from Entact Bio, is an advisor to Pluvia Biotech, and receives research funding from Arbor Biotechnologies. The University of Pennsylvania and Children’s Hospital of Philadelphia have filed patent applications related to the use of base editing for the treatment of phenylketonuria and tyrosinemia (inventors include M.N.W., D.L.B., R.C.A.-N., K.M., W.H.P. and X.W.). The remaining authors declare no competing interests.
