Garge, Riddhiman K. https://orcid.org/0000-0002-6774-0172
Lynch, Valerie
Fields, Rose
Casadei, Silvia
Best, Sabrina
Stone, Jeremy https://orcid.org/0000-0002-7565-2463
Snyder, Matthew https://orcid.org/0000-0001-7433-4343
Kubo, Connor https://orcid.org/0000-0001-9579-2917
Wakimoto, Arata
Liu, Zukai https://orcid.org/0000-0001-5738-4357
McGann, Chris D. https://orcid.org/0000-0001-9379-1910
Shendure, Jay https://orcid.org/0000-0002-1516-1865
Starita, Lea M. https://orcid.org/0000-0003-2870-5099
Hamazaki, Nobuhiko https://orcid.org/0000-0001-9228-233X
Schweppe, Devin K. https://orcid.org/0000-0002-3241-6276
Funding for this research was provided by:
U.S. Department of Health & Human Services | NIH | National Institute of General Medical Sciences (R35GM150919)
Pew Charitable Trusts
Washington Research Foundation Andy Hill CARE Fund
U.S. Department of Health & Human Services | NIH | National Human Genome Research Institute (1RM1HG010461)
U.S. Department of Health & Human Services | NIH | National Human Genome Research Institute (1RM1HG010461)
Washington Research Foundation Postdoctoral Fellowship
Howard Hughes Medical Institute
Paul G. Allen Frontiers Group Brotman Baty Institute for Precision Medicine
Article History
Received: 11 April 2025
Accepted: 20 March 2026
First Online: 24 April 2026
Competing interests
: J. Shendure is on the scientific advisory board, a consultant and/or a co-founder of Prime Medicine, Guardant Health, Camp4 Therapeutics, Phase Genomics, Adaptive Biotechnologies, Sixth Street Capital, Pacific Biosciences, Cellular Intelligence and 10x Genomics. D.K.S. is a consultant and/or collaborator with ThermoFisher Scientific, AI Proteins, Genentech and Matchpoint Therapeutics. The remaining authors declare no competing interests.