Kozlova, Nina https://orcid.org/0000-0002-4944-7917
Cruz, Kayla A.
Ruzette, Antoine A.
Doh, Hanna M.
Willis, Nicholas A.
Hong, Su Min https://orcid.org/0009-0006-8472-9924
Gonzalez, Raul S. https://orcid.org/0000-0001-5526-4220
Vyas, Monika
Selfors, Laura M. https://orcid.org/0000-0002-1317-7353
Dreyer, Stephan
Upstill-Goddard, Rosie
Faia, Kerrie L. https://orcid.org/0000-0002-6504-160X
Wenglowsky, Steve
Close, Josh https://orcid.org/0000-0003-0696-3759
Beutel, Alica
Jutric, Zeljka
Oliphant, Michael U. J. https://orcid.org/0000-0003-2563-6489
Poluben, Larysa
Thapa, Byanjana
Taylor, Martin S. https://orcid.org/0000-0003-1560-9276
Mustonen, Venla https://orcid.org/0000-0002-5124-7711
Mangalath, Pradeep
Halbrook, Christopher J. https://orcid.org/0000-0002-3376-3114
Grossman, Joseph E. https://orcid.org/0000-0002-2130-2783
Hwang, Rosa F.
Clohessy, John G. https://orcid.org/0000-0001-5186-9775
Ruskamo, Salla
Kursula, Petri https://orcid.org/0000-0001-8529-3751
Petrova, Boryana https://orcid.org/0000-0001-9996-9353
Kanarek, Naama https://orcid.org/0000-0002-2068-3908
Cole, Philip A. https://orcid.org/0000-0001-6873-7824
Chang, David K. https://orcid.org/0000-0002-4821-3078
Evans, Conor L. https://orcid.org/0000-0003-2185-6505
Nørrelykke, Simon F. https://orcid.org/0000-0001-8302-526X
Scully, Ralph https://orcid.org/0000-0002-5064-0175
Muranen, Taru https://orcid.org/0000-0003-4158-9002
Funding for this research was provided by:
American Cancer Society (RSG-19-0201-CSM)
U.S. Department of Health & Human Services | National Institutes of Health (R01CA258372)
U.S. Department of Health & Human Services | National Institutes of Health (3R35CA242428)
U.S. Department of Health & Human Services | National Institutes of Health (R37CA283575)
U.S. Department of Health & Human Services | National Institutes of Health (R01CA095175)
U.S. Department of Health & Human Services | National Institutes of Health (R01GM134425)
U.S. Department of Health & Human Services | National Institutes of Health (R01CA74305)
Suomen Kulttuurirahasto (N/A)
Harvard Medical School (Foundry Award)
Harvard Medical School (BBS graduate program)
Harvard Medical School (BBS graduate program)
Harvard Medical School (Foundry award)
Cancer Research UK
Cancer Council NSW
National Science Foundation (DGE 2140743)
V Foundation for Cancer Research (V2021-026)
National Pancreas Foundation (NPF-5615796)
Janne and Aatos Erkko Foundation, Finland
Department of Health | National Health and Medical Research Council
Cancer Institute NSW
Royal Australasian College of Surgeons
St. Vincent's Clinic Foundation
Boston Children's Hospital (BTREC)
Pew Charitable Trusts (Pew Scholar)
Prostate Cancer Foundation (24YOUN29)
Article History
Received: 12 December 2025
Accepted: 23 March 2026
First Online: 27 April 2026
Competing interests
: K.L.F., S.W. and J.C. are employees of Blueprint Medicines Corporation and provided the SGK inhibitor BLU6340 and declare no competing interests. Other authors declare no competing interests.