Dunsmore, Lavinia http://orcid.org/0000-0002-9125-6081
Navo, Claudio D. http://orcid.org/0000-0003-0161-412X
Becher, Julie http://orcid.org/0000-0002-8417-4475
de Montes, Enrique Gil
Guerreiro, Ana
Hoyt, Emily http://orcid.org/0000-0001-6940-8803
Brown, Libby
Zelenay, Viviane
Mikutis, Sigitas http://orcid.org/0000-0003-0064-639X
Cooper, Jonathan
Barbieri, Isaia http://orcid.org/0000-0003-3035-8970
Lawrinowitz, Stefanie
Siouve, Elise
Martin, Esther
Ruivo, Pedro R.
Rodrigues, Tiago
da Cruz, Filipa P.
Werz, Oliver http://orcid.org/0000-0002-5064-4379
Vassiliou, George http://orcid.org/0000-0003-4337-8022
Ravn, Peter
Jiménez-Osés, Gonzalo http://orcid.org/0000-0003-0105-4337
Bernardes, Gonçalo J. L. http://orcid.org/0000-0001-6594-8917
Article History
Received: 4 February 2021
Accepted: 3 May 2022
First Online: 27 June 2022
Competing interests
: P.R., V.Z., E.S. and E.M. are or were formerly employed by AstraZeneca plc. L.D., J.B., E.G.d.M. and G.J.L.B. are inventors on a patent application (GB2207691.3) that incorporates discoveries described in this manuscript. T.R. and G.J.L.B. are inventors on a patent that describes the discovery of the allosteric inhibition of 5-LO by β-lapachone (PCT/PT2018/050029), which is related to parts of the work related in this manuscript. The authors of this article declare that V. Cantrill, who was involved with the editing of this article, is employed by G.J.L.B. as a research coordinator at the University of Cambridge. V. Cantrill is married to S. Cantrill, who is the Chief Editor of <i>Nature Chemistry</i>. All other authors declare no competing interests.<b>Publisher Note:</b> The editorial team of <i>Nature Chemistry</i> declare that Stuart Cantrill has had no involvement in the editorial handling of this article.