Fricke, Riley http://orcid.org/0000-0001-9463-6314
Swenson, Cameron V. http://orcid.org/0000-0002-9896-3539
Roe, Leah Tang http://orcid.org/0000-0002-2487-5587
Hamlish, Noah Xue http://orcid.org/0000-0003-4318-8675
Shah, Bhavana
Zhang, Zhongqi http://orcid.org/0000-0002-8326-6714
Ficaretta, Elise
Ad, Omer
Smaga, Sarah http://orcid.org/0000-0003-3469-2642
Gee, Christine L. http://orcid.org/0000-0002-2632-6418
Chatterjee, Abhishek http://orcid.org/0000-0002-6231-5302
Schepartz, Alanna http://orcid.org/0000-0003-2127-3932
Funding for this research was provided by:
National Science Foundation (2002182)
Article History
Received: 14 March 2022
Accepted: 28 April 2023
First Online: 1 June 2023
Competing interests
: R.F., C.V.S. and A.S. have submitted a patent application ‘Methods to Generate Novel Acyl-tRNA Species’ (2022, US Patent application no. PCT/US23/63304) related to this work. The application discloses PylRS enzymes that accept α-hydroxy acids, α-thio acids, <i>N</i>-formyl-<scp>l</scp>-α-amino acids and α-carboxy acid monomers (malonic acids) that are formally precursors to polyketide natural products, and methods of use.