Kaveladze, Benjamin T. https://orcid.org/0000-0001-7289-5040
Voelkel, Jan G.
Stagnaro, Michael N.
Huang, Mingjing
Smock, Amanda E. https://orcid.org/0009-0000-1255-8149
Sullivan, Erin K.
Xu, Yao M. https://orcid.org/0009-0009-3538-2671
McCall, Madison P.
Zapata, Juan Pablo
Ahmed, Syed Ishtiaque
Bhattacharjee, Ananya
Georgieva, Iva
Hernandez-Ramos, Rosa
Huber, Kenneth S.
Jennings, Julia K.
Kirk, Arianna C.
Knowles, Robert S. M.
Kornfield, Rachel https://orcid.org/0000-0001-8542-6913
Lind, Monika Neff
Liu, Michelle
Liut, Michael A. https://orcid.org/0000-0003-2965-5302
Mariakakis, Alex T.
Mattu, Ali M.
McGuire, Adam P. https://orcid.org/0000-0002-4512-1207
Meyerhoff, Jonah https://orcid.org/0000-0001-5149-7959
Mrazek, Alissa J. https://orcid.org/0000-0003-3178-1789
Mrazek, Michael D.
Mohr, David C. https://orcid.org/0000-0002-5443-7596
Morris, Robert R.
Mosunic, Christopher J.
Nip, Hana
Olson-Urtecho, Allen
Podell, Jessa R.
Ransom, Dustyn S.
Rizvi, Shireen L.
Southward, Matthew W.
Stoeckl, Sarah Elizabeth
Taylor, Madison E.
Texter, Amy R. https://orcid.org/0009-0008-7971-1361
Tower, Calvin V. https://orcid.org/0000-0002-1284-6228
Trotter, Angelique N.
Williams, Joseph J.
Wislocki, Katherine E.
Woodson, Elijah J.
Protzko, John
Lorenzo-Luaces, Lorenzo
Schueller, Stephen M.
Nock, Matthew K.
Schleider, Jessica L.
Funding for this research was provided by:
U.S. Department of Health & Human Services | NIH | National Institute of Mental Health (T32 MH115882)
U.S. Department of Health & Human Services | National Institutes of Health (R01MH135502)
Article History
Received: 28 July 2025
Accepted: 23 January 2026
First Online: 2 March 2026
Competing interests
: The authors declare the following competing interests. Virtually everyone who contributed an intervention that was tested—S.I.A., A.B., I.G., R.H.-R., K.S.H., J.K.J., A.C.K., R.S.M.K., R.K., M.N.L., M.L., M.A.L., A.T.M., A.M.M., A.P.M., J.M., A.J.M., M.D.M., D.C.M., R.R.M., C.J.M., H.N., A.O.-U., J.R.P., D.S.R., S.L.R., M.W.S., S.E.S., M.E.T., A.R.T., C.V.T., A.N.T. and J.J.W.—probably had a competing interest in that they wanted their intervention to perform well in the experiment and wanted to present the results in a positive light for their intervention. To account for these competing interests, the core authorship team did not accept input from intervention contributors on the experimental design and primary and secondary preregistered outcomes. Submitters were permitted to comment on a draft of the final paper and suggest edits via a publicly viewable online document that all authors could see. The Lab for Scalable Mental Health received a US$10,000 donation from Calm Health and used all of it to fund the megastudy experiment. Given this financial support and the possibility of future support, members of the Lab for Scalable Mental Health (B.T.K., M.H., A.E.S. and J.P.Z.) may have been motivated to present findings regarding Calm Health’s SSI Reframing Negative Thoughts in a positive light. J.M. has accepted consulting fees from Boehringer Ingelheim and Shirley Ryan Ability Lab. M.K.N. receives publication royalties from Macmillan, Pearson and UpToDate. He has been a paid consultant in the past 3 years for Cambridge Health Alliance, and for legal cases regarding a death by suicide. He has stock options in Cerebral Inc. He is an unpaid scientific advisor for Empatica, Koko, TalkLife and the JED Foundation. S.L.R. earns ad revenue from YouTube. L.L.L. was supported by NIH grant R01MH135502. L.L.L. has received consulting fees from Syra Health, Inc., who had no involvement in the current project. S.M.S. has received consulting payments from Boehringer Ingelheim and Otsuka Pharmaceuticals and is a member of the Headspace Scientific Advisory Board, for which he receives compensation. J.L.S. has served on the Scientific Advisory Board for Walden Wise and the Clinical Advisory Board for Koko (unpaid) and receives book royalties from New Harbinger; Oxford University Press; and Little, Brown Book Group. She is cofounder and chief scientific advisor for Navi. No Navi products were used or are referenced in this paper. The other authors declare no competing interests.