Buffa, Jennifer A.
Romano, Kymberleigh A.
Copeland, Matthew F.
Cody, David B.
Zhu, Weifei
Galvez, Rachel
Fu, Xiaoming
Ward, Kathryn
Ferrell, Marc
Dai, Hong J.
Skye, Sarah
Hu, Ping https://orcid.org/0000-0003-1100-9361
Li, Lin https://orcid.org/0000-0003-1578-9182
Parlov, Mirjana
McMillan, Amy
Wei, Xingtao https://orcid.org/0000-0002-6908-0948
Nemet, Ina https://orcid.org/0000-0002-0657-7121
Koeth, Robert A.
Li, Xinmin S.
Wang, Zeneng
Sangwan, Naseer
Hajjar, Adeline M. https://orcid.org/0000-0002-4838-8070
Dwidar, Mohammed https://orcid.org/0000-0003-1366-0393
Weeks, Taylor L.
Bergeron, Nathalie
Krauss, Ronald M.
Tang, W. H. Wilson
Rey, Federico E. https://orcid.org/0000-0002-0239-7780
DiDonato, Joseph A.
Gogonea, Valentin
Gerberick, G. Frank
Garcia-Garcia, Jose Carlos
Hazen, Stanley L. https://orcid.org/0000-0001-7124-6639
Funding for this research was provided by:
U.S. Department of Health & Human Services | National Institutes of Health (R01HL106003, R01HL106003, R01HL126827, P01HL147823, R01HL126827)
U.S. Department of Health & Human Services | NIH | National Center for Advancing Translational Sciences (UL1TR000004, UL1TR000004)
Fondation Leducq (17CVD01, 17CVD01)
Article History
Received: 18 February 2021
Accepted: 28 October 2021
First Online: 23 December 2021
Competing interests
: S.L.H. and Z.W. report being named as co-inventors on pending and issued patents held by the Cleveland Clinic relating to cardiovascular diagnostics and therapeutics. They also report having received royalty payments for inventions or discoveries related to cardiovascular diagnostics or therapeutics from Cleveland Heart Lab, a fully owned subsidiary of Quest Diagnostics, and Procter & Gamble. S.L.H. is a paid consultant for Procter & Gamble and Zehna Therapeutics, and has received research funds from Procter & Gamble, Pfizer Inc., Roche Diagnostics and Zehna Therapeutics. J.B. reports having received royalty payments from Procter & Gamble. G.F.G., M.F.C., D.B.C., K.L.W., B.R.L.G., H.J.D., P.H. and J.C.G.G. are employees of Procter & Gamble. W.H.W.T. reports being a consultant for Sequana Medical A.G., Owkin Inc, Relypsa Inc. and PreCardiac Inc., having received honoraria from Springer Nature for authorship/editorship and the American Board of Internal Medicine for exam-writing committee participation—all unrelated to the subject and contents of the present paper. The other authors declare that they have no relationships relevant to the contents of this paper to disclose.