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Authors
Chan, Alvin https://orcid.org/0000-0002-1041-3891
Kirtane, Ameya R. https://orcid.org/0000-0002-3779-0363
Qu, Qing Rui https://orcid.org/0009-0008-4938-5745
Huang, Xisha
Woo, Jonathan https://orcid.org/0009-0001-6950-0041
Subramanian, Deepak A. https://orcid.org/0000-0001-6224-7533
Dey, Rajib https://orcid.org/0009-0002-4844-368X
Semalty, Rika https://orcid.org/0009-0004-1884-6706
Bernstock, Joshua D.
Ahmed, Taksim https://orcid.org/0000-0001-7143-4621
Honeywell, Rowan
Hanhurst, Charles https://orcid.org/0009-0006-4049-4852
Diaz Becdach, Isaac https://orcid.org/0009-0001-1890-6885
Prizant, Leah S. https://orcid.org/0009-0006-6866-9853
Brown, Ashley K. https://orcid.org/0009-0005-2022-1534
Song, Hao https://orcid.org/0000-0002-6383-0605
Law Cobb, Justin
DeRidder, Louis B. https://orcid.org/0000-0001-7390-1481
Santos, Bruna
Jimenez, Miguel https://orcid.org/0000-0003-4211-1852
Sun, Michelle
Huang, Yuebin https://orcid.org/0009-0009-0031-3617
Byrne, Ceara
Traverso, Giovanni https://orcid.org/0000-0001-7851-4077
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Funding
Funding for this research was provided by:
ARPA-H
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Article History
Received: 25 May 2024
Accepted: 13 June 2025
First Online: 15 August 2025
Change Date: 26 August 2025
Change Type: Update
Change Details: In the version of the article initially published, the GitHub link (
Change Details: https://github.com/alvinchangw/COMET
Change Details: ) was missing from the Code availability statement and has now been added to the HTML and PDF versions of the article.
Competing interests
: The authors declare the submission of a provisional patent application encompassing the work described. A.C., A.R.K., Q.R.Q., X.H., R.D., J.W., D.A.S., J.D.B., H.S., T.A., J.L.C. and G.T. have filed for intellectual property (US Patent application no. 63/700,337) regarding the use of LNP formulations discussed in this paper. Complete details of all relationships for profit and not for profit for G.T. can be found at the following link: . J.D.B. has positions and equity in Pockit Diagnostics Ltd. J.D.B. also has an equity position in Treovir Inc. and is on the boards of Centile Bio and NeuroX1. M.J. consults for VitaKey. The other authors declare no competing interests.
