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Article History

Received: 16 July 2019

Accepted: 13 November 2019

First Online: 8 January 2020

Competing interests

: R.C. has received research grants from British Heart Foundation, Cancer Research UK, Medical Research Council, Merck & Co, UKBiobank, Wellcome and Medco; a Pfizer Prize Award (to NDPH) and is named on a patent for a statin-related myopathy genetic test. R.C. receives no personal remuneration from these: any share of royalties or other payments have been waived in favour of NDPH. E.T.D. is chairman and board member of Hybridstat and on the advisory board of DNAnexus. M.E.H. is a co-founder, shareholder and director of Congenica. S.K. has received research grants from Bayer and Novartis; is on Scientific Advisory Boards of Regeneron Genetics Center, Corvidia Therapeutics and Maze Therapeutics; has equity in San Therapeutics, Catabasis, Verve and Maze Therapeutics and is a consultant for Maze Therapeutics, Alynlam, ExpertConnect, Leerink Partners, Noble Insights, Bayer and Novo Ventures. E.E.K. receives honoraria from Illumina and Regeneron Pharmaceuticals. C.M.L. has research collaborations with Novo Nordisk and Bayer, receiving no personal payment. D.G.M. is co-founder and shareholder of Goldfinch Bio and has received research funding from AbbVie, Biogen, BioMarin, Merck, Pfizer and Sanofi-Genzyme. S.E.P. is a member of the Scientific Advisory Board of Baylor Genetics. J.S. is a member of the Scientific Advisory Board for Maze Therapeutics, Camp4 Therapeutics, Nanostring, Phase Genomics, Adaptive Biotechnology and Stratos Genomics, a founder of Phase Genomics and a consultant for Guardant Health. M.I.M. was a member of advisory panels for Pfizer, NovoNordisk and Zoe Global; received honoraria from Merck, Pfizer, NovoNordisk and Eli Lilly and research funding from Abbvie, Astra Zeneca, Boehringer Ingelheim, Eli Lilly, Janssen, Merck, NovoNordisk, Pfizer, Roche, Sanofi Aventis, Servier and Takeda. As of June 2019, M.I.M. is an employee of Genentech and a holder of Roche stock. The views expressed in this article are those of the author(s) and not necessarily those of the NHS, the NIHR, or the Department of Health.