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Article History
Received: 18 May 2021
Accepted: 10 January 2022
First Online: 16 March 2022
Competing interests
: The authors are current or former employees of Merck Sharp & Dohme Corp., a subsidiary of Merck & Co., Inc., Kenilworth, NJ, USA or Codexis, Inc., which are assignees for patents governing chemical matter, processes and enzyme sequences reported in the article.