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Authors
Abbosh, Christopher https://orcid.org/0000-0002-8983-1382
Frankell, Alexander M. https://orcid.org/0000-0002-0341-7878
Harrison, Thomas
Kisistok, Judit
Garnett, Aaron
Johnson, Laura
Veeriah, Selvaraju
Moreau, Mike
Chesh, Adrian
Chaunzwa, Tafadzwa L.
Weiss, Jakob
Schroeder, Morgan R.
Ward, Sophia https://orcid.org/0000-0002-6777-5279
Grigoriadis, Kristiana https://orcid.org/0000-0002-8435-0176
Shahpurwalla, Aamir
Litchfield, Kevin
Puttick, Clare
Biswas, Dhruva https://orcid.org/0000-0001-9141-5188
Karasaki, Takahiro https://orcid.org/0000-0001-6863-2360
Black, James R. M.
Martínez-Ruiz, Carlos https://orcid.org/0000-0002-4817-0565
Bakir, Maise Al https://orcid.org/0000-0002-0846-8332
Pich, Oriol https://orcid.org/0000-0002-1956-1882
Watkins, Thomas B. K.
Lim, Emilia L.
Huebner, Ariana https://orcid.org/0000-0001-8009-4999
Moore, David A. https://orcid.org/0000-0002-6296-1312
Godin-Heymann, Nadia https://orcid.org/0000-0003-3260-0302
L’Hernault, Anne
Bye, Hannah
Odell, Aaron
Kalavakur, Paula
Gomes, Fabio
Patel, Akshay J.
Manzano, Elizabeth
Hiley, Crispin T.
Carey, Nicolas https://orcid.org/0000-0002-2660-9178
Riley, Joan
Cook, Daniel E. https://orcid.org/0000-0003-3347-562X
Hodgson, Darren
Stetson, Daniel
Barrett, J. Carl
Kortlever, Roderik M. https://orcid.org/0000-0001-5558-2851
Evan, Gerard I. https://orcid.org/0000-0003-0412-1216
Hackshaw, Allan https://orcid.org/0000-0002-5570-5070
Daber, Robert D.
Shaw, Jacqui A. https://orcid.org/0000-0003-4227-503X
Aerts, Hugo J. W. L. https://orcid.org/0000-0002-2122-2003
Licon, Abel
Stahl, Josh
Jamal-Hanjani, Mariam https://orcid.org/0000-0003-1212-1259
,
Lester, Jason F.
Bajaj, Amrita
Nakas, Apostolos
Sodha-Ramdeen, Azmina
Ang, Keng
Tufail, Mohamad
Chowdhry, Mohammed Fiyaz
Scotland, Molly
Boyles, Rebecca
Rathinam, Sridhar
Wilson, Claire
Marrone, Domenic
Dulloo, Sean
Fennell, Dean A.
Matharu, Gurdeep
Primrose, Lindsay
Boleti, Ekaterini
Cheyne, Heather
Khalil, Mohammed
Richardson, Shirley
Cruickshank, Tracey
Price, Gillian
Kerr, Keith M.
Benafif, Sarah
Gilbert, Kayleigh
Naidu, Babu
Osman, Aya
Lacson, Christer
Langman, Gerald
Shackleford, Helen
Djearaman, Madava
Kadiri, Salma
Middleton, Gary
Leek, Angela
Hodgkinson, Jack Davies
Totten, Nicola
Montero, Angeles
Smith, Elaine
Fontaine, Eustace
Granato, Felice
Doran, Helen
Novasio, Juliette
Rammohan, Kendadai
Joseph, Leena
Bishop, Paul
Shah, Rajesh
Moss, Stuart
Joshi, Vijay
Crosbie, Philip
Brown, Kate
Carter, Mathew
Chaturvedi, Anshuman
Priest, Lynsey
Oliveira, Pedro
Lindsay, Colin R.
Blackhall, Fiona H.
Krebs, Matthew G.
Summers, Yvonne
Clipson, Alexandra
Tugwood, Jonathan
Kerr, Alastair
Rothwell, Dominic G.
Kilgour, Elaine
Dive, Caroline
Schwarz, Roland F.
Kaufmann, Tom L.
Wilson, Gareth A.
Rosenthal, Rachel
Van Loo, Peter
Szallasi, Zoltan
Sokac, Mateo
Salgado, Roberto
Diossy, Miklos
Demeulemeester, Jonas
Bunkum, Abigail
Stewart, Aengus
Magness, Alastair
Rowan, Andrew
Karamani, Angeliki
Toncheva, Antonia
Chain, Benny
Campbell, Brittany B.
Castignani, Carla
Bailey, Chris
Weeden, Clare E.
Lee, Claudia
Richard, Corentin
Naceur-Lombardelli, Cristina
Pearce, David R.
Karagianni, Despoina
Levi, Dina
Hoxha, Elena
Larose Cadieux, Elizabeth
Colliver, Emma
Nye, Emma
Grönroos, Eva
Gálvez-Cancino, Felip
Athanasopoulou, Foteini
Gimeno-Valiente, Francisco
Kassiotis, George
Stavrou, Georgia
Mastrokalos, Gerasimos
Zhai, Haoran
Lowe, Helen L.
Matos, Ignacio
Goldman, Jacki
Reading, James L.
Herrero, Javier
Rane, Jayant K.
Nicod, Jerome
Lam, Jie Min
Hartley, John A.
Peggs, Karl S.
Enfield, Katey S. S.
Selvaraju, Kayalvizhi
Thol, Kerstin
Ng, Kevin W.
Chen, Kezhong
Dijkstra, Krijn
Thakkar, Krupa
Ensell, Leah
Shah, Mansi
Vasquez, Marcos
Litovchenko, Maria
Werner Sunderland, Mariana
Hill, Mark S.
Dietzen, Michelle
Leung, Michelle
Escudero, Mickael
Angelova, Mihaela
Tanić, Miljana
Sivakumar, Monica
Kanu, Nnennaya
Chervova, Olga
Lucas, Olivia
Al-Sawaf, Othman
Prymas, Paulina
Hobson, Philip
Pawlik, Piotr
Stone, Richard Kevin
Bentham, Robert
Hynds, Robert E.
Vendramin, Roberto
Saghafinia, Sadegh
López, Saioa
Gamble, Samuel
Ung, Seng Kuong Anakin
Quezada, Sergio A.
Vanloo, Sharon
Zaccaria, Simone
Hessey, Sonya
Boeing, Stefan
Beck, Stephan
Bola, Supreet Kaur
Denner, Tamara
Marafioti, Teresa
Mourikis, Thanos P.
Spanswick, Victoria
Barbè, Vittorio
Lu, Wei-Ting
Hill, William
Liu, Wing Kin
Wu, Yin
Naito, Yutaka
Ramsden, Zoe
Veiga, Catarina
Royle, Gary
Collins-Fekete, Charles-Antoine
Fraioli, Francesco
Ashford, Paul
Clark, Tristan
Forster, Martin D.
Lee, Siow Ming
Borg, Elaine
Falzon, Mary
Papadatos-Pastos, Dionysis
Wilson, James
Ahmad, Tanya
Procter, Alexander James
Ahmed, Asia
Taylor, Magali N.
Nair, Arjun
Lawrence, David
Patrini, Davide
Navani, Neal
Thakrar, Ricky M.
Janes, Sam M.
Martinoni Hoogenboom, Emilie
Monk, Fleur
Holding, James W.
Choudhary, Junaid
Bhakhri, Kunal
Scarci, Marco
Hayward, Martin
Panagiotopoulos, Nikolaos
Gorman, Pat
Khiroya, Reena
Stephens, Robert CM.
Wong, Yien Ning Sophia
Bandula, Steve
Sharp, Abigail
Smith, Sean
Gower, Nicole
Dhanda, Harjot Kaur
Chan, Kitty
Pilotti, Camilla
Leslie, Rachel
Grapa, Anca
Zhang, Hanyun
AbdulJabbar, Khalid
Pan, Xiaoxi
Yuan, Yinyin
Chuter, David
MacKenzie, Mairead
Chee, Serena
Alzetani, Aiman
Cave, Judith
Scarlett, Lydia
Richards, Jennifer
Ingram, Papawadee
Austin, Silvia
Lim, Eric
De Sousa, Paulo
Jordan, Simon
Rice, Alexandra
Raubenheimer, Hilgardt
Bhayani, Harshil
Ambrose, Lyn
Devaraj, Anand
Chavan, Hema
Begum, Sofina
Buderi, Silviu I.
Kaniu, Daniel
Malima, Mpho
Booth, Sarah
Nicholson, Andrew G.
Fernandes, Nadia
Shah, Pratibha
Proli, Chiara
Hewish, Madeleine
Danson, Sarah
Shackcloth, Michael J.
Robinson, Lily
Russell, Peter
Blyth, Kevin G.
Dick, Craig
Le Quesne, John
Kirk, Alan
Asif, Mo
Bilancia, Rocco
Kostoulas, Nikos
Thomas, Mathew
Birkbak, Nicolai J. https://orcid.org/0000-0003-1613-9587
McGranahan, Nicholas https://orcid.org/0000-0001-9537-4045
Swanton, Charles https://orcid.org/0000-0002-4299-3018
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Article History
Received: 6 April 2022
Accepted: 30 January 2023
First Online: 13 April 2023
Competing interests
: C.A. has received speaking honoraria or expenses from AstraZeneca and Bristol-Myers Squibb and reports employment at AstraZeneca. C.A. and C.S. are listed as inventors on a European patent application relating to assay technology to detect tumour recurrence (PCT/GB2017/053289). This patent has been licensed to commercial entities and, under their terms of employment, C.A and C.S are due a revenue share of any revenue generated from such license(s). C.A. and C.S. declare a patent application (PCT/US2017/028013) for methods to detect lung cancer. A.M.F., C.A. and C.S. are named inventors on a patent application to determine methods and systems for tumour monitoring (PCT/EP2022/077987). C.A., C.S., K.L., C.P., T.H., L.J., M.R.S., A.G. and A. Licon are named inventors on a provisional patent protection related to a ctDNA detection algorithm. S.V. is listed as a co-inventor on a patent of methods for detecting molecules in a sample (US patent, 10,578,620). T.H., A.G., M.M., A.C., A.S., A.O., L.J., P.K., M.R.S., R.D.D., A.L. and J.S. are former or current employees of Invitae or ArcherDx and report stock ownership. D.B. reports personal fees from NanoString and AstraZeneca and has a patent (PCT/GB2020/050221) application on methods for cancer prognostication. M.A.B. has consulted for Achilles Therapeutics. D.A.M. reports speaker fees from AstraZeneca, Eli Lilly and Takeda; consultancy fees from AstraZeneca, Thermo Fisher Scientific, Takeda, Amgen, Janssen, MIM Software, Bristol-Myers Squibb and Eli Lilly; and has received educational support from Takeda and Amgen. N.G.-H., A. L’Hernault, H.B., D.H., D.S. and J.C.B. report stock ownership and employment at AstraZeneca. A. Hackshaw has received fees for being a member of independent data monitoring committees for Roche-sponsored clinical trials, and academic projects co-ordinated by Roche. C.T.H. has received speaker fees from AstraZeneca. M.J.-H. has consulted for, and is a member of, the Achilles Therapeutics scientific advisory board and steering committee; has received speaker honoraria from Pfizer, Astex Pharmaceuticals, Oslo Cancer Cluster; and is listed as a co-inventor on a European patent application relating to methods to detect lung cancer (PCT/US2017/028013). This patent has been licensed to commercial entities and, under terms of employment, M.J.-H. is due a share of any revenue generated from such license(s). N.J.B. is listed as a co-inventor on a patent to identify responders to cancer treatment (PCT/GB2018/051912), has a patent application (PCT/GB2020/050221) on methods for cancer prognostication and a patent on methods for predicting anti-cancer response (US14/466,208). H.J.W.L.A. has received personal fees and stock from Onc.AI, Sphera and Love Health, and speaking honoraria from Bristol-Myers Squibb. K.L. has a patent (CA3068366A) on indel burden and CPI response pending and speaker fees from Roche tissue diagnostics and Ellipses Pharmaceuticals, research funding from CRUK TDL/Ono/LifeArc alliance, Genesis Therapeutics and consulting roles with Monopteros Therapeutics and Kynos Therapeutics (all outside of this work). N.M. has received consultancy fees and has stock options in Achilles Therapeutics; and holds European patents relating to targeting neoantigens (PCT/EP2016/059401), identifying patient response to immune checkpoint blockade (PCT/EP2016/071471), determining HLA LOH (PCT/GB2018/052004) and predicting survival rates of patients with cancer (PCT/GB2020/050221). C.S. acknowledges grant support from AstraZeneca, Boehringer-Ingelheim, Bristol-Myers Squibb, Pfizer, Roche-Ventana, Invitae (previously Archer Dx, collaboration in minimal residual disease sequencing technologies), Ono Pharmaceutical and Personalis; he is an AstraZeneca advisory board member and chief investigator for the AZ MeRmaiD 1 and 2 clinical trials and is also co-chief investigator of the NHS Galleri trial funded by GRAIL and a paid member of GRAIL’s scientific advisory board. He receives consultant fees from Achilles Therapeutics (also a member of the scientific advisory board), Bicycle Therapeutics (also a member of the scientific advisory board), Genentech, Medicxi, Roche Innovation Centre–Shanghai, Metabomed (until July 2022) and the Sarah Cannon Research Institute; has received honoraria from Amgen, AstraZeneca, Pfizer, Novartis, GlaxoSmithKline, MSD, Bristol-Myers Squibb, Illumina and Roche-Ventana; had stock options in Apogen Biotechnologies and GRAIL until June 2021, and currently has stock options in Epic Bioscience, Bicycle Therapeutics, and has stock options and is co-founder of Achilles Therapeutics; and holds additional patent applications related to targeting neoantigens (PCT/EP2016/059401), identifying patient response to immune checkpoint blockade (PCT/EP2016/071471), determining HLA LOH (PCT/GB2018/052004), predicting survival rates of patients with cancer (PCT/GB2020/050221), identifying patients who respond to cancer treatment (PCT/GB2018/051912) and both a European and US patent application related to identifying insertion/deletion mutation targets (PCT/GB2018/051892).
