Updates are available Correction dated 2023-07-03
Click to view Correction: https://doi.org/10.1038/s41586-023-06375-z
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Authors
Wong, Waihay J. http://orcid.org/0000-0003-2023-6590
Emdin, Connor
Bick, Alexander G.
Zekavat, Seyedeh M. http://orcid.org/0000-0003-4026-8944
Niroula, Abhishek
Pirruccello, James P. http://orcid.org/0000-0001-6088-4037
Dichtel, Laura
Griffin, Gabriel
Uddin, Md Mesbah http://orcid.org/0000-0003-1846-0411
Gibson, Christopher J. http://orcid.org/0000-0002-3700-5310
Kovalcik, Veronica
Lin, Amy E.
McConkey, Marie E.
Vromman, Amelie http://orcid.org/0000-0002-1724-2095
Sellar, Rob S.
Kim, Peter G. http://orcid.org/0000-0002-8716-8759
Agrawal, Mridul
Weinstock, Joshua http://orcid.org/0000-0001-7013-1899
Long, Michelle T. http://orcid.org/0000-0001-6131-3981
Yu, Bing
Banerjee, Rajarshi
Nicholls, Rowan C. http://orcid.org/0000-0002-3311-4974
Dennis, Andrea
Kelly, Matt http://orcid.org/0000-0002-5834-635X
Loh, Po-Ru http://orcid.org/0000-0001-5542-9064
McCarroll, Steve http://orcid.org/0000-0002-6954-8184
Boerwinkle, Eric
Vasan, Ramachandran S. http://orcid.org/0000-0001-7357-5970
Jaiswal, Siddhartha http://orcid.org/0000-0002-9597-0477
Johnson, Andrew D. http://orcid.org/0000-0001-6369-5178
Chung, Raymond T.
Corey, Kathleen
Levy, Daniel http://orcid.org/0000-0003-1843-8724
Ballantyne, Christie http://orcid.org/0000-0002-6432-1730
,
Abe, Namiko
Abecasis, Gonçalo
Aguet, Francois
Albert, Christine
Almasy, Laura
Alonso, Alvaro
Ament, Seth
Anderson, Peter
Anugu, Pramod
Applebaum-Bowden, Deborah
Ardlie, Kristin
Arking, Dan
Arnett, Donna K.
Ashley-Koch, Allison
Aslibekyan, Stella
Assimes, Tim
Auer, Paul
Avramopoulos, Dimitrios
Ayas, Najib
Balasubramanian, Adithya
Barnard, John
Barnes, Kathleen
Barr, R. Graham
Barron-Casella, Emily
Barwick, Lucas
Beaty, Terri
Beck, Gerald
Becker, Diane
Becker, Lewis
Beer, Rebecca
Beitelshees, Amber
Benjamin, Emelia
Benos, Takis
Bezerra, Marcos
Bielak, Larry
Bis, Joshua
Blackwell, Thomas
Blangero, John
Blue, Nathan
Bowden, Donald W.
Bowler, Russell
Brody, Jennifer
Broeckel, Ulrich
Broome, Jai
Brown, Deborah
Bunting, Karen
Burchard, Esteban
Bustamante, Carlos
Buth, Erin
Cade, Brian
Cardwell, Jonathan
Carey, Vincent
Carrier, Julie
Carson, April P.
Carty, Cara
Casaburi, Richard
Casas Romero, Juan P.
Casella, James
Castaldi, Peter
Chaffin, Mark
Chang, Christy
Chang, Yi-Cheng
Chasman, Daniel
Chavan, Sameer
Chen, Bo-Juen
Chen, Wei-Min
Chen, Yii-Der Ida
Cho, Michael
Choi, Seung Hoan
Chuang, Lee-Ming
Chung, Mina
Chung, Ren-Hua
Clish, Clary
Comhair, Suzy
Conomos, Matthew
Cornell, Elaine
Correa, Adolfo
Crandall, Carolyn
Crapo, James
Cupples, L. Adrienne
Curran, Joanne
Curtis, Jeffrey
Custer, Brian
Damcott, Coleen
Darbar, Dawood
David, Sean
Davis, Colleen
Daya, Michelle
de Andrade, Mariza
de las Fuentes, Lisa
de Vries, Paul
DeBaun, Michael
Deka, Ranjan
DeMeo, Dawn
Devine, Scott
Dinh, Huyen
Doddapaneni, Harsha
Duan, Qing
Dugan-Perez, Shannon
Duggirala, Ravi
Durda, Jon Peter
Dutcher, Susan K.
Eaton, Charles
Ekunwe, Lynette
El Boueiz, Adel
Ellinor, Patrick
Emery, Leslie
Erzurum, Serpil
Farber, Charles
Farek, Jesse
Fingerlin, Tasha
Flickinger, Matthew
Fornage, Myriam
Franceschini, Nora
Frazar, Chris
Fu, Mao
Fullerton, Stephanie M.
Fulton, Lucinda
Gabriel, Stacey
Gan, Weiniu
Gao, Shanshan
Gao, Yan
Gass, Margery
Geiger, Heather
Gelb, Bruce
Geraci, Mark
Germer, Soren
Gerszten, Robert
Ghosh, Auyon
Gibbs, Richard
Gignoux, Chris
Gladwin, Mark
Glahn, David
Gogarten, Stephanie
Gong, Da-Wei
Goring, Harald
Graw, Sharon
Gray, Kathryn J.
Grine, Daniel
Gross, Colin
Gu, C. Charles
Guan, Yue
Guo, Xiuqing
Gupta, Namrata
Haessler, Jeff
Hall, Michael
Han, Yi
Hanly, Patrick
Harris, Daniel
Hawley, Nicola L.
He, Jiang
Heavner, Ben
Heckbert, Susan
Hernandez, Ryan
Herrington, David
Hersh, Craig
Hidalgo, Bertha
Hixson, James
Hobbs, Brian
Hokanson, John
Hong, Elliott
Hoth, Karin
Hsiung, Chao
Hu, Jianhong
Hung, Yi-Jen
Huston, Haley
Hwu, Chii Min
Irvin, Marguerite Ryan
Jackson, Rebecca
Jain, Deepti
Jaquish, Cashell
Johnsen, Jill
Johnson, Craig
Johnston, Rich
Jones, Kimberly
Kang, Hyun Min
Kaplan, Robert
Kardia, Sharon
Kelly, Shannon
Kenny, Eimear
Kessler, Michael
Khan, Alyna
Khan, Ziad
Kim, Wonji
Kimoff, John
Kinney, Greg
Konkle, Barbara
Kooperberg, Charles
Kramer, Holly
Lange, Christoph
Lange, Ethan
Lange, Leslie
Laurie, Cathy
Laurie, Cecelia
LeBoff, Meryl
Lee, Jiwon
Lee, Sandra
Lee, Wen-Jane
LeFaive, Jonathon
Levine, David
Lewis, Joshua
Li, Xiaohui
Li, Yun
Lin, Henry
Lin, Honghuang
Lin, Xihong
Liu, Simin
Liu, Yongmei
Liu, Yu
Loos, Ruth J. F.
Lubitz, Steven
Lunetta, Kathryn
Luo, James
Magalang, Ulysses
Mahaney, Michael
Make, Barry
Manichaikul, Ani
Manning, Alisa
Manson, JoAnn
Martin, Lisa
Marton, Melissa
Mathai, Susan
Mathias, Rasika
May, Susanne
McArdle, Patrick
McDonald, Merry-Lynn
McFarland, Sean
McGarvey, Stephen
McGoldrick, Daniel
McHugh, Caitlin
McNeil, Becky
Mei, Hao
Meigs, James
Menon, Vipin
Mestroni, Luisa
Metcalf, Ginger
Meyers, Deborah A.
Mignot, Emmanuel
Mikulla, Julie
Min, Nancy
Minear, Mollie
Minster, Ryan L.
Mitchell, Braxton D.
Moll, Matt
Momin, Zeineen
Montasser, May E.
Montgomery, Courtney
Muzny, Donna
Mychaleckyj, Josyf C.
Nadkarni, Girish
Naik, Rakhi
Naseri, Take
Nekhai, Sergei
Nelson, Sarah C.
Neltner, Bonnie
Nessner, Caitlin
Nickerson, Deborah
Nkechinyere, Osuji
North, Kari
O’Connell, Jeff
O’Connor, Tim
Ochs-Balcom, Heather
Okwuonu, Geoffrey
Pack, Allan
Paik, David T.
Palmer, Nicholette
Pankow, James
Papanicolaou, George
Parker, Cora
Peloso, Gina
Peralta, Juan Manuel
Perez, Marco
Perry, James
Peters, Ulrike
Peyser, Patricia
Phillips, Lawrence S.
Pleiness, Jacob
Pollin, Toni
Post, Wendy
Powers Becker, Julia
Preethi Boorgula, Meher
Preuss, Michael
Psaty, Bruce
Qasba, Pankaj
Qiao, Dandi
Qin, Zhaohui
Rafaels, Nicholas
Raffield, Laura
Rajendran, Mahitha
Rao, D. C.
Rasmussen-Torvik, Laura
Ratan, Aakrosh
Redline, Susan
Reed, Robert
Reeves, Catherine
Regan, Elizabeth
Reiner, Alex
Reupena, Muagututi‘a Sefuiva
Rice, Ken
Rich, Stephen
Robillard, Rebecca
Robine, Nicolas
Roden, Dan
Roselli, Carolina
Rotter, Jerome
Ruczinski, Ingo
Runnels, Alexi
Russell, Pamela
Ruuska, Sarah
Ryan, Kathleen
Sabino, Ester Cerdeira
Saleheen, Danish
Salimi, Shabnam
Salvi, Sejal
Salzberg, Steven
Sandow, Kevin
Sankaran, Vijay G.
Santibanez, Jireh
Schwander, Karen
Schwartz, David
Sciurba, Frank
Seidman, Christine
Seidman, Jonathan
Sériès, Frédéric
Sheehan, Vivien
Sherman, Stephanie L.
Shetty, Amol
Shetty, Aniket
Sheu, Wayne Hui-Heng
Shoemaker, M. Benjamin
Silver, Brian
Silverman, Edwin
Skomro, Robert
Smith, Albert Vernon
Smith, Jennifer
Smith, Josh
Smith, Nicholas
Smith, Tanja
Smoller, Sylvia
Snively, Beverly
Snyder, Michael
Sofer, Tamar
Sotoodehnia, Nona
Stilp, Adrienne M.
Storm, Garrett
Streeten, Elizabeth
Su, Jessica Lasky
Sung, Yun Ju
Sylvia, Jody
Szpiro, Adam
Taliun, Daniel
Tang, Hua
Taub, Margaret
Taylor, Kent D.
Taylor, Matthew
Taylor, Simeon
Telen, Marilyn
Thornton, Timothy A.
Threlkeld, Machiko
Tinker, Lesley
Tirschwell, David
Tishkoff, Sarah
Tiwari, Hemant
Tong, Catherine
Tracy, Russell
Tsai, Michael
Vaidya, Dhananjay
Van Den Berg, David
VandeHaar, Peter
Vrieze, Scott
Walker, Tarik
Wallace, Robert
Walts, Avram
Wang, Fei Fei
Wang, Heming
Wang, Jiongming
Watson, Karol
Watt, Jennifer
Weeks, Daniel E.
Weir, Bruce
Weiss, Scott T.
Weng, Lu-Chen
Wessel, Jennifer
Willer, Cristen
Williams, Kayleen
Williams, L. Keoki
Williams, Scott
Wilson, Carla
Wilson, James
Winterkorn, Lara
Wong, Quenna
Wu, Joseph
Xu, Huichun
Yanek, Lisa
Yang, Ivana
Yu, Ketian
Zhang, Yingze
Zhao, Snow Xueyan
Zhao, Wei
Zhu, Xiaofeng
Ziv, Elad
Zody, Michael
Zoellner, Sebastian
Ebert, Benjamin L. http://orcid.org/0000-0003-0197-5451
Natarajan, Pradeep http://orcid.org/0000-0001-8402-7435
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Article History
Received: 23 October 2020
Accepted: 16 February 2023
First Online: 12 April 2023
Change Date: 14 April 2023
Change Type: Update
Change Details: In the version of this article initially published, Benjamin L. Ebert was not listed as a corresponding author, while Pradeep Natarajan was shown with an incorrect email address; the changes are made in the HTML and PDF versions of the article.
Change Date: 3 July 2023
Change Type: Correction
Change Details: A Correction to this paper has been published:
Change Details: https://doi.org/10.1038/s41586-023-06375-z
Competing interests
: W.J.W., C. Emdin, B.L.E. and P.N. are inventors on a US provisional patent application related to this work filed by Massachusetts General Hospital and Dana-Farber Cancer Institute (number 63/116,382, filed 20 November 2020). P.N. reports grant support from Amgen, Apple, AstraZeneca, Boston Scientific and Novartis, and personal fees from Allelica, Apple, AstraZeneca, Blackstone Life Sciences, Foresite Labs, Invitae, Novartis, Roche/Genetech and TenSixteen Bio, is a scientific advisory board member of Esperion Therapeutics, geneXwell and TenSixteen Bio, and reports spousal employment at and equity in Vertex, all distinct from the present work. C. Emdin reports personal fees from Acceleron Pharma, Korro Bio, Navitor Pharma, Nference, Novartis and Third Rock Ventures, all distinct from the present work. B.L.E. has received research financial support from Celgene, Deerfield, Novartis and Calico, and consulting fees from GRAIL, and serves on the scientific advisory boards for Neomorph Therapeutics, Skyhawk Therapeutics and Exo Therapeutics, all distinct from the present work. P.N. and B.L.E. are scientific co-founders of TenSixteen Bio, which focuses on somatic mosaicism and precision medicine. L.D. has received research support from Perspectum Ltd, Pfizer, Lumos Pharma and Recordati, is a MGB Innovation Fellow hosted by Third Rock Ventures (a venture capital firm) and remains full time at MGH during the period of this educational program (anticipated 1 October 2022–30 September 2024); the financial interests of L.D. were reviewed and are managed by MGH and MGB in accordance with their conflict-of-interest policies. M.A. received consulting fees from German Accelerator Life Sciences and is a co-founder of and holds equity in iuvando Health, all unrelated to the present work. R. Banerjee, R.C.N., A.D. and M. Kelly receive salaries from and have stock options in Perspectum and research interests in liver and cardiometabolic disease. S.J. is on advisory boards for Novartis, AVRO Bio and Roche Genentech, is a paid consultant for Foresite Labs, reports speaking fees and an honorarium from GSK, is an equity holder and a scientific advisory board member of Bitterroot Bio, and is a co-founder, equity holder, and scientific advisory board member of TenSixteen Bio. R.T.C. has received grant support to his institution from Abbvie, Boehringer, Gilead, Merck, BMS, Roche, Janssen and GSK all unrelated to the present work. All other authors declare no competing interests.
