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Article History
Received: 15 July 2022
Accepted: 28 August 2023
First Online: 4 October 2023
Competing interests
: This manuscript stems from a collaboration between the Broad Institute, AbbVie and Calico Sciences. Equal financial support for the design and study conduct for this research were provided by AbbVie and Calico. R.T.M. and K.B.Y. receive research funding from Calico Life Sciences. C.K.B., K.M.H., K.A.M., K.H., K.L.K., R.D., L.M., R.M., C. Backus, D.E.K., A.C., J.T.K., C.L.H., C.W.H., J.P.D., M.B., J.H.D., Y.Y., M.G., S.F., P. Trusk, W.Q., Q.S., E.P.F., M.A.M., J.M.F. and P.R.K. are employees of AbbVie. P.G. was an employee of AbbVie at the time she contributed to the manuscript and is now an employee of Bristol Myers Squibb. Z.X. was an employee of AbbVie at the time he contributed to the manuscript and is now an employee of Ipsen Therapeutics. K.L. was an employee of AbbVie at the time he contributed to the manuscript. N.K. was an employee of AbbVie at the time he contributed to the manuscript and is now an employee of Pfizer. G.T.H. is a deceased author who was an employee of AbbVie at the time of the study. A.I.-V. was an employee of the Broad Institute at the time he contributed to the manuscript and is now an employee of Monte Rosa Therapeutics. M.N.P., C.H.P., I.-M.S. and Y.L. are employees of Calico Life Sciences. T.R.G. has paid scientific advisory roles and equity in Dewpoint Therapeutics and Anji Pharmaceuticals, holds founder’s equity in Sherlock Biosciences, is a paid advisor to Braidwell and has research funding from Bayer HealthCare, Calico Life Sciences and Novo Holdings. R.T.M. has received consulting or speaking fees from Bristol Myers Squibb, Gilead Sciences and Immunai Therapeutics, has equity ownership in OncoRev, and receives research funding from Calico Life Sciences. C. Beauregard was an employee of Calico Life Sciences at the time he contributed to the manuscript and is now an employee of Vir Biotechnology. AbbVie, Calico Life Sciences and the Broad Institute participated in the interpretation of data, review and approval of the publication. The remaining authors declare no competing interests.