Oldak, Bernardo
Wildschutz, Emilie
Bondarenko, Vladyslav
Comar, Mehmet-Yunus
Zhao, Cheng
Aguilera-Castrejon, Alejandro http://orcid.org/0000-0002-1339-7778
Tarazi, Shadi http://orcid.org/0000-0002-4121-4289
Viukov, Sergey
Pham, Thi Xuan Ai
Ashouokhi, Shahd
Lokshtanov, Dmitry
Roncato, Francesco
Ariel, Eitan
Rose, Max
Livnat, Nir
Shani, Tom http://orcid.org/0000-0002-4878-2174
Joubran, Carine
Cohen, Roni
Addadi, Yoseph http://orcid.org/0000-0001-9827-0436
Chemla, Muriel
Kedmi, Merav
Keren-Shaul, Hadas
Pasque, Vincent
Petropoulos, Sophie
Lanner, Fredrik http://orcid.org/0000-0002-2771-7445
Novershtern, Noa http://orcid.org/0000-0002-2244-6877
Hanna, Jacob H. http://orcid.org/0000-0003-2042-9974
Article History
Received: 11 April 2023
Accepted: 4 September 2023
First Online: 6 September 2023
Competing interests
: J.H.H. together with B.O., E.W., V.B., A.A.-C., N.N., S.V., S.T., C.J., T.S. and F.R. submitted (through Yeda–Weizmann Institute of Science) patent applications relevant to the findings and technologies reported and media compositions utilized herein: (1) “Isolated naive pluripotent stem cells and methods of generating same” filed on 23 April 2013 (EP 61/814,920); (2) “Media for culturing naive pluripotent stem cells” filed on 30 July 2014 (EP 62/030,792); (3) “Culture media for pluripotent stem cells” filed on 23 January 2020 (EP 62/795,626); (4) “Methods and devices for ex-utero mouse embryonic development” (for natural and synthetic embryos) filed on 16 March 2021 (EP 281,561); (5) “Methods of generating a synthetic embryo” (for mouse and human SEMs/synthetic embryo models) filed on 6 March 2022 (EP 63/317,036). J.H.H. is a co-founder and chief scientific advisor of Renewal Bio, which has licensed technologies described herein and co-funded some parts of this project. RSeT defined human naive-like pluripotency growth medium was licensed and commercialized by Stem Cell Technologies based on some of the indicated patents/patent applications above (RSeT is the commercialized version of NHSM growth medium<sup>7</sup> originally generated and patented by J.H.H. and N.N). The remaining authors declare no competing interests.