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Authors
Bennett, Nathaniel R.
Watson, Joseph L. https://orcid.org/0000-0001-5492-0249
Ragotte, Robert J.
Borst, Andrew J.
See, DéJenaé L.
Weidle, Connor
Biswas, Riti https://orcid.org/0000-0003-3766-1980
Yu, Yutong https://orcid.org/0009-0000-4656-9700
Shrock, Ellen L.
Ault, Russell
Leung, Philip J. Y. https://orcid.org/0000-0002-1801-8968
Huang, Buwei
Goreshnik, Inna
Tam, John
Carr, Kenneth D. https://orcid.org/0009-0005-1929-3952
Singer, Benedikt
Criswell, Cameron
Wicky, Basile I. M. https://orcid.org/0000-0002-2501-7875
Vafeados, Dionne https://orcid.org/0000-0002-2560-8907
Garcia Sanchez, Mariana https://orcid.org/0009-0002-9194-0251
Kim, Ho Min https://orcid.org/0000-0003-0029-3643
Vázquez Torres, Susana
Chan, Sidney https://orcid.org/0000-0002-1617-0464
Sun, Shirley M. https://orcid.org/0009-0007-6764-5750
Spear, Timothy T.
Sun, Yi
O’Reilly, Keelan https://orcid.org/0009-0005-9907-9859
Maris, John M. https://orcid.org/0000-0002-8088-7929
Sgourakis, Nikolaos G. https://orcid.org/0000-0003-3655-3902
Melnyk, Roman A. https://orcid.org/0000-0002-7187-2362
Liu, Chang C. https://orcid.org/0000-0002-3290-2880
Baker, David https://orcid.org/0000-0001-7896-6217
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Article History
Received: 25 February 2025
Accepted: 8 October 2025
First Online: 5 November 2025
Competing interests
: N.R.B., J.L.W., R.J.R., A.J.B., C.W., P.J.Y.L., B.H. and D.B. are co-inventors on US provisional patent number 63/607,651, which covers the computational antibody design pipeline described here. N.R.B., J.L.W., P.J.Y.L. and B.H. are currently employed by Xaira Therapeutics. N.R.B., J.L.W., P.J.Y.L., B.H., R.J.R., A.J.B. and C.W. have received payments relating to the licensing of the inventions described here to Xaira Therapeutics. C.C.L. is a co-founder of K2 Therapeutics, which uses OrthoRep in antibody engineering and evolution. The other authors declare no competing interests.
