Moore, Jill E. https://orcid.org/0000-0002-3023-0806
Pratt, Henry E.
Fan, Kaili https://orcid.org/0000-0002-8723-7902
Phalke, Nishigandha
Fisher, Jonathan
Elhajjajy, Shaimae I.
Andrews, Gregory
Gao, Mingshi https://orcid.org/0000-0002-7524-892X
Shedd, Nicole
Fu, Yu
Lacadie, Matthew C.
Meza, Jair
Khandpekar, Mansi
Ganna, Mohit
Choudhury, Eva
Swofford, Ross https://orcid.org/0000-0003-3676-8479
Phan, Huong https://orcid.org/0009-0006-2339-3806
Ramirez, Christian C.
Campbell, Maxwell https://orcid.org/0009-0001-6352-0463
Likhite, Mary
Farrell, Nina P.
Weimer, Annika K. https://orcid.org/0000-0001-9944-8769
Pampari, Anusri
Ramalingam, Vivekanandan https://orcid.org/0000-0002-3631-8913
Reese, Fairlie
Borsari, Beatrice https://orcid.org/0000-0003-4357-3557
Yu, Xuezhu
Wattenberg, Eve
Ruiz-Romero, Marina https://orcid.org/0000-0002-8382-1052
Razavi-Mohseni, Milad
Xu, Jinrui
Galeev, Timur
Colubri, Andres
Beer, Michael A. https://orcid.org/0000-0001-9955-3809
Guigó, Roderic https://orcid.org/0000-0002-5738-4477
Gerstein, Mark B. https://orcid.org/0000-0002-9746-3719
Engreitz, Jesse M. https://orcid.org/0000-0002-5754-1719
Ljungman, Mats https://orcid.org/0000-0003-1553-6695
Reddy, Timothy E. https://orcid.org/0000-0002-7629-061X
Snyder, Michael P. https://orcid.org/0000-0003-0784-7987
Epstein, Charles B. https://orcid.org/0000-0001-8358-8345
Gaskell, Elizabeth
Bernstein, Bradley E. https://orcid.org/0000-0002-5726-6278
Dickel, Diane E.
Visel, Axel https://orcid.org/0000-0002-4130-7784
Pennacchio, Len A. https://orcid.org/0000-0002-8748-3732
Mortazavi, Ali https://orcid.org/0000-0002-4259-6362
Kundaje, Anshul https://orcid.org/0000-0003-3084-2287
Weng, Zhiping https://orcid.org/0000-0002-3032-7966
Article History
Received: 19 December 2024
Accepted: 12 November 2025
First Online: 7 January 2026
Competing interests
: J.M.E. is an inventor on patents and patent applications related to CRISPR screening technologies, has received materials from 10× Genomics unrelated to this study, and has received speaking honoraria from GSK, Amgen, and Genentech. B.E.B. discloses financial interests in HiFiBio, Arsenal Biosciences, Chroma Medicine and Cell Signaling Technologies. M.P.S. is a co-founder and on the advisory boards of Personalis, Qbio, January AI, SensOmics, Filtricine, Protos, Mirvie, Onza, Marble Therapeutics, Iollo and NextThought AI. He is also on the advisory boards of Jupiter, Applied Cognition, Neuvivo, Mitrix, and Enovone. A.K. is a consulting fellow with Illumina; a member of the scientific advisory boards of OpenTargets (GSK), PatchBio and SerImmune; and a co-founder of RavelBio. Z.W. is a co-founder of Rgenta Therapeutics and serves on its scientific advisory board. The other authors declare no competing interests.