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Article History
Received: 23 May 2025
Accepted: 5 December 2025
First Online: 28 January 2026
Competing interests
: O.S.B., F.H., X.Z.Z, B.H., M.A.F., S.M., Q.W. and S.P. are current employees and/or stockholders of AstraZeneca. R.S.D. is a paid consultant of AstraZeneca. C.A.L. is a consultant to Cartography Biosciences. The remaining authors declare no competing interests.