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Jacob, Walter https://orcid.org/0000-0001-9649-4989
Gaebel, Lena
Heiser, Merlin https://orcid.org/0000-0001-5232-0688
Wolfram, Christopher https://orcid.org/0009-0002-8113-9102
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Gindri Dos Santos, Bernardo
Toh, Pamela
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Khamhoung, Annie
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Goswami, Sukanya
Nelson, Daniella
Chen, Rachel
D’Souza, Darwin
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Ellinor, Patrick T.
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Article History
Received: 4 May 2025
Accepted: 8 May 2026
First Online: 10 June 2026
Competing interests
: C.S.M. is a consultant for Granite Bio, unrelated to the present work. M.C.H. reports consulting fees from Comanche Biopharma; site principal investigator work and advisory board service for Novartis; and research support from Genentech, unrelated to the present work. S.K. has received sponsored research support from Bayer AG, unrelated to the present work. P.N. reports research grants from Allelica, Amgen, Apple, Boston Scientific, Cleerly, Genentech/Roche, Ionis, Novartis and Silence Therapeutics; personal fees from Allelica, Apple, AstraZeneca, Bain Capital, Blackstone Life Sciences, Bristol Myers Squibb, Creative Education Concepts, CRISPR Therapeutics, Eli Lilly & Co, Esperion Therapeutics, Foresite Capital, Foresite Labs, Genentech/Roche, GV, HeartFlow, Magnet Biomedicine, Merck, Novartis, Novo Nordisk, TenSixteen Bio and Tourmaline Bio; equity in Bolt, Candela, Mercury, MyOme, Parameter Health, Preciseli and TenSixteen Bio; and spousal employment at Vertex Pharmaceuticals, all unrelated to the present work. The other authors declare no competing interests.