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Authors
ElHarouni, Dina
Al-Jazrawe, Mushriq https://orcid.org/0000-0002-4267-4236
Choi, Seongmin https://orcid.org/0000-0001-9722-1800
Dede, Merve https://orcid.org/0000-0002-0868-5863
Hinoue, Toshinori
Misek, Sean A.
Noh, Heeju
Zanella, Luca https://orcid.org/0000-0001-7955-0168
Tseng, Yuen-Yi
Francies, Hayley E.
Plenker, Dennis https://orcid.org/0000-0003-3895-4064
Kyi, Cindy W.
Perez-Mayoral, Julyann
Stine, Megan J.
Tonsing-Carter, Eva https://orcid.org/0000-0002-4133-5566
Agarwal, Rachana
Zenklusen, Jean Claude
Clinton, James M.
Shelton, Jennifer M.
Chu, Timothy R.
Hooper, William F. https://orcid.org/0000-0002-0078-8921
Loinaz, Xavi
Keskula, Paula
Tagle, Jordan https://orcid.org/0000-0002-0983-0495
Kuhlers, Peyton C.
Tercan, Bahar
Boj, Sylvia F.
Vasciaveo, Alessandro https://orcid.org/0000-0003-0205-9869
Tomassoni, Lorenzo
Crawford, James M.
Walsh, Shawna
Sinai, Claire
Bhatia, Sonam https://orcid.org/0000-0002-0124-2621
Sridevi, Priya
Patel, Hardik https://orcid.org/0009-0002-9242-1795
Cerone, Maria Antonietta
,
Akadri, Mubarak
Aguirre, Andrew J.
Akbani, Rehan
Al Assaad, Majd
Al Zoughbi, Wael
Al-Ibraheemi, Alyaa
Alkhairy, Sahar
Altorki, Nasser
Andreani, Silvia
Araya, Joshua
Arun, Gayatri
Atari, Adel
Avril, Stefanie
Baker, Toby M.
Balaban, Metin
Barnes, Michael
Barrett, Caitlyn W.
Bass, Adam
Beck, Alexandra E.
Belleau, Pascal
Benz, Christopher C.
Bhinder, Bhavneet
Bhosle, Shriram G.
Boerner, Julie
Bowen, Jay
Brais, Lauren
Broom, Bradley M.
Bullen, Catherine A.
Buscaglia, Jonathan M.
Caiazza, Thomas Anthony
Campbell, Joshua D.
Cantillo, Evelyn
Cao, Song
Capuano, Jared A.
Castro, Mauro A. A.
Chapman-Davis, Eloise
Chiotti, Kami
Choueiri, Toni K.
Chow, Kin-Hoe
Chukwu, Wolu
Church, Alanna J.
Clevers, Hans
Clinton, Catherine
Cortes-Ciriano, Isidro
Costa, Daniel B.
Cote, Gregory M.
Crompton, Brian D.
D’Agosto, Sabrina
Dalin, Simona
Davis, Melissa
De Smet, Frederik
Deasy, Rebecca
Delmar, Mimoun
Denoya, Paula I.
Deschênes, Astrid
Ding, Li
Duffy, Elizabeth R.
Dzvurumi, Ruvimbo
Eng, Kenneth
Valle-Inclan, Jose Espejo
Faltas, Bishoy M.
Feenstra, Michelle
Flores, Idhaliz
Fox, Sharon B.
Frey, Melissa K.
Frimer, Marina
Geduldig, Jack
Geurts, Veerle
Getz, Gad
Gilbert, James G. R.
Goldberg, Gary L.
Goodwin, Sara
Gregersen, Peter K.
Grossman, Evan
Gupta, Akansha A.
Habowski, Amber N.
Hahn, William C.
Hammerman, Peter
Hayes, D. Neil
Heiman, David I.
Henske, Elizabeth P.
Herranz-Ors, Carmen
Hess, Julian M.
Holcomb, Kevin
Hong, Andrew L.
Hudson, Christine
Hung, Victoria
Iliev, Lora
Janeway, Katherine A.
Japo, Julia O.
Johnson, Grace
Ju, Jihang
Kane, Troy J.
Klempner, Samuel J.
Kramer, Melissa
Kramm, Anneke
Krasnitz, Alexander
Kumar, Shwetha V.
Lawlor, Rita Teresa
Lee, Gwo-Shu Mary
Lee, Siyun
Li, Hongyu
Li, Ellen
Liistro, Madison
Lorch, Jochen
Lucchesi, Carolina
Luchini, Claudio
Malinowski, Seth
Manohar, Jyothi
Martello, Laura A.
Marti, Jennifer L.
Martin, M. Laura
Mashl, R. Jay
McCombie, W. Richard
McCormick, Aaron K.
McSteen, Brian W.
Metz, Christine N.
Molina, Ana
Mosquera, Juan Miguel
Moyer, Jenna E.
Murphy, Anthony
Naik, Payal
Nair, Indu
Nanus, David M.
Nasajpour, Emon
Nauseef, Jones T.
Newman, Lisa
Ng, Kimmie
Ng, Samuel Y.
Ocean, Allyson
Oh, Coyin
Ohara, Kentaro
Ozler, Kadir
Panchot, Kila
Pavao, Nicole
Pea, Antonio
Pelton, Kristine
Peng, Anson
Petritsch, Claudia K.
Pradhan, Payal
Puram, Sidharth V.
Qi, Meifang
Raghavan, Srivatsan
Raphael, Benjamin J.
Requena, David
Reuben, Phoebe L.
Rheinbay, Esther
Rishi, Arvind
Rios, Carmen
Robertson, A. Gordon
Ronning, Peter
Ruehr, Ashley R.
Russo, Suzanne
Ruzzenente, Andrea
Ryan, Michael
Salvia, Roberto
Sandak, David
Sarmashghi, Shahab
Saxena, Ashish
Sayeed, Abeer
Shukla, Parul
Sboner, Andrea
Scarpa, Aldo
Scherr, Douglas S.
Serafini, Francesco
Shen, Hui
Shetty, Aniket
Shah, Manish
Sicinska, Ewa
Signoretti, Sabina
Sigouros, Michael
Smith, Amber R.
Song, Yizhe
Song, Yingduo
Soria, Conrado T.
Sternberg, Cora
Stuart, Joshua M.
Thompson, Cheryl L.
Tsang, Natalie
Tsherniak, Aviad
Valente, Cristina
Valentini, Sara
van Es, Johan H.
Van Hare, Barbara
Vignesh, Shivakumar
Vogelzang, Jayne
Ward, Abigail
Watkinson, Fiona
Webster, Sophie
Weinstein, John N.
Weinstock, David M.
Wendl, Michael C.
Wolpin, Brian M.
Wong, Christopher K.
Wu, Maoxin
Wyczalkowski, Matthew A.
Wysocki, William P.
Yeagley, Alexa
Yerrum, Smitha
Yoon, Charles H.
Yuan, Jenny
Yueh, Brian
Zhang, Zhenyu
Ellrott, Kyle https://orcid.org/0000-0002-6573-5900
Kuo, Calvin J. https://orcid.org/0000-0002-7427-5985
Elemento, Olivier https://orcid.org/0000-0002-8061-9617
Beyaz, Semir https://orcid.org/0000-0003-4730-4012
Corbo, Vincenzo https://orcid.org/0000-0002-6340-8009
Spector, David L. https://orcid.org/0000-0003-3614-4965
Beroukhim, Rameen https://orcid.org/0000-0001-6303-3609
Ferguson, Martin L. https://orcid.org/0000-0002-2050-4199
Cherniack, Andrew D. https://orcid.org/0000-0003-0470-0111
Laird, Peter W. https://orcid.org/0000-0001-9117-3641
Robine, Nicolas https://orcid.org/0000-0001-5698-8183
McPherson, Andrew https://orcid.org/0000-0002-5654-5101
Hoadley, Katherine A. https://orcid.org/0000-0002-1216-477X
Garnett, Mathew J. https://orcid.org/0000-0002-2618-4237
Tuveson, David A. https://orcid.org/0000-0002-8017-2712
Califano, Andrea https://orcid.org/0000-0003-4742-3679
Spellman, Paul T. https://orcid.org/0000-0002-4810-0022
Ligon, Keith L. https://orcid.org/0000-0002-7733-600X
Gerhard, Daniela S.
Staudt, Louis M.
Boehm, Jesse S. https://orcid.org/0000-0002-6795-6336
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Article History
Received: 8 February 2025
Accepted: 22 May 2026
First Online: 5 August 2026
Ethics
Competing interests: A.C. is the founder, equity holder and consultant of DarwinHealth, a company that has licensed some of the algorithms used in this paper from Columbia University. Columbia University is also an equity holder in DarwinHealth. A.D.C. receives research funding from Bayer and consults for KaryoVerse. H.C. is an inventor on patents related to organoid research. His full disclosure can be found at . G.G. receives research funds from IBM, Pharmacyclics/AbbVie, Bayer, Genentech, Calico and Ultima Genomics. He is also an inventor on patent applications filed by the Broad Institute related to MSMuTect, MSMutSig, POLYSOLVER, SignatureAnalyzer-GPU, MSEye and MinimuMM-seq. He is a founder, consultant and holds privately held equity in Scorpion Therapeutics; he is also a founder of, and holds privately held equity in, PreDICTA Biosciences. G.G. was also a consultant to Merck. K.L.L. is the founder, equity holder and consultant for Travera, is a consultant for Bristol Myers Squibb, Servier, Blaze Biosciences, Integragen and L.E.K. Consulting, and has received research funding to DFCI from Bristol Myers Squibb and Lilly. D.A.T. is a co-founder, consultant and holds stock options from Mestag Therapeutics; is a consultant and holds stock options from Xilis; and has received research grant support from Fibrogen, Mestag and ONO Therapeutics. M.K.’s spouse is an Illumina Field Applications employee and holds stock in the company. L.T. works at DarwinHealth, a company that has licensed some of the algorithms used in this paper from Columbia University. P.W.L. is a member of the Scientific Advisory Board of FOXO Technologies and TAGOMICS, Limited. W.R.M. is a founder, board member and scientific advisory board member of Orion Genomics, a plant genomics company (institutional affiliations: Genetics Program–SUNY Stony Brook; affiliate member: New York Genome Center). J.T.N. is an employee of Convergent Therapeutics and has received honoraria, consulting or advisory fees from Pfizer, AIQ and Bayer. E.R. participates in a research collaboration funded by Inocras. S.S. receives research funding from AstraZeneca and Bristol Myers Squibb outside the scope of this work. S.R. receives research support from Microsoft and holds equity in Amgen. The remaining authors declare no competing interests.
