Spindler, Matthew J.
Nelson, Ayla L.
Wagner, Ellen K.
Oppermans, Natasha http://orcid.org/0000-0002-3399-9178
Bridgeman, John S.
Heather, James M. http://orcid.org/0000-0002-1783-5181
Adler, Adam S. http://orcid.org/0000-0001-9301-0037
Asensio, Michael A. http://orcid.org/0000-0001-9087-0568
Edgar, Robert C.
Lim, Yoong Wearn
Meyer, Everett H.
Hawkins, Robert E.
Cobbold, Mark http://orcid.org/0000-0001-8931-4142
Johnson, David S. http://orcid.org/0000-0002-9967-9812
Funding for this research was provided by:
U.S. Department of Health & Human Services | NIH | National Cancer Institute (R43CA232942)
RCUK | Engineering and Physical Sciences Research Council (EP/L014904/1)
U.S. Department of Health & Human Services | NIH | National Institute of Allergy and Infectious Diseases (R43AI120313-01)
Article History
Received: 2 April 2019
Revised: 21 January 2020
Accepted: 27 January 2020
First Online: 16 March 2020
Competing interests
: M.J.S., A.L.N., E.K.W., A.S.A., M.A.A., Y.W.L., R.C.E. and D.S.J. are salaried employees of GigaGen, which is an affiliate of GigaMune. GigaMune pays cash to GigaGen for research services. M.J.S., A.L.N., E.K.W., A.S.A., M.A.A., R.C.E., Y.W.L., E.H.M., M.C. and D.S.J. are holders of equity shares in GigaMune. J.M.H. and M.C. hold research positions at the Massachusetts General Hospital. Massachusetts General Hospital has entered into a research collaboration with GigaMune. M.C. is currently an employee of AstraZeneca. M.C. owns equity in Revitope Oncology and Gritstone Oncology. M.C. received consultant fees from Merck Laboratories. J.S.B. and R.E.H. are salaried employees of Immetacyte. R.E.H. is a holder of equity shares in Immetacyte. The viral TCRs and TCR repertoire mining methods are described in US Patent and Trademark Office (USPTO) provisional patent application 62/821808, assigned to GigaMune (M.J.S., A.L.N., E.K.W., Y.W.L., A.S.A., M.A.A. and D.S.J.). The PMEL TCRs are described in USPTO provisional patent application 62/842691, assigned to GigaMune (M.J.S., A.S.A., M.A.A. and D.S.J.). Methods for generating TCR libraries are described in patents WO2012083225A2, US20160362470A1, US20170247684A1 and US20170247683A1, assigned to GigaGen or GigaMune (M.J.S., A.S.A., E.H.M. and D.S.J.).