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Authors
Liew, Fungmin Eric
Nogle, Robert
Abdalla, Tanus
Rasor, Blake J. https://orcid.org/0000-0001-6662-341X
Canter, Christina
Jensen, Rasmus O.
Wang, Lan
Strutz, Jonathan
Chirania, Payal
De Tissera, Sashini
Mueller, Alexander P.
Ruan, Zhenhua
Gao, Allan
Tran, Loan
Engle, Nancy L. https://orcid.org/0000-0003-0290-7987
Bromley, Jason C.
Daniell, James https://orcid.org/0000-0003-0831-4349
Conrado, Robert
Tschaplinski, Timothy J. https://orcid.org/0000-0002-9540-6622
Giannone, Richard J.
Hettich, Robert L. https://orcid.org/0000-0001-7708-786X
Karim, Ashty S. https://orcid.org/0000-0002-5789-7715
Simpson, Séan D.
Brown, Steven D.
Leang, Ching https://orcid.org/0000-0001-8694-5504
Jewett, Michael C. https://orcid.org/0000-0003-2948-6211
Köpke, Michael https://orcid.org/0000-0003-0642-1415
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Funding
Funding for this research was provided by:
DOE | Office of Energy Efficiency & Renewable Energy | Bioenergy Technologies Office (DE-EE0007566, DE-EE0007566, DE-EE0007566, DE-EE0007566, DE-EE0007566, DE-EE0007566, DE-EE0007566, DE-EE0007566, DE-EE0007566, DE-EE0007566, DE-EE0007566, DE-EE0007566, DE-EE0007566, DE-EE0007566, DE-EE0007566, DE-EE0007566, DE-EE0007566, DE-EE0007566, DE-EE0007566, DE-EE0007566, DE-EE0007566)
DOE | Office of Science (DE-SC0018249, DE-SC0018249, FWP ERKP903, DE-AC05-00OR22725, DE-SC0018249, DE-SC0018249, FWP ERKP903, DE-AC05-00OR22725, DE-SC0018249, FWP ERKP903, DE-AC05-00OR22725, DE-SC0018249, FWP ERKP903, DE-AC05-00OR22725, DE-SC0018249, FWP ERKP903, DE-AC05-00OR22725, DE-SC0018249, DE-SC0018249, DE-SC0018249, DE-SC0018249, CSP-503280, DE-SC0018249, CSP-503280)
U.S. Department of Defense (ND-CEN-017-095)
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Article History
Received: 6 October 2020
Accepted: 9 December 2021
First Online: 21 February 2022
Competing interests
: F.L., R.N., T.A., C.C., R.O.J., L.W., J.S., S.T., A.P.M., A.G., L.T., J.C.B., J.D., R.C., S.D.S., S.D.B., C.L. and M.K. are current or former employees of LanzaTech, a for-profit company pursuing commercialization of the acetone and isopropanol gas fermentation process discussed here. M.C.J. consults for and has joint funding with LanzaTech. F.L. and M.K. are co-inventors on granted US patent 9,365,868 (assigned to LanzaTech) related to the production of acetone and isopropanol by fermentation of a gaseous substrate comprising CO that incorporates discoveries incorporated in this manuscript. M.K. is co-inventor on granted US patent 9,550,979 (assigned to LanzaTech) related to alcohol dehydrogenases with engineered metabolic activity that incorporates discoveries incorporated in this manuscript. R.O.J., A.P.M. and M.K. are co-inventors on US patent application 2015/0152445 (assigned to LanzaTech) related to inactivation of secondary alcohol dehydrogenases that incorporates discoveries incorporated in this manuscript. C.L. is an inventor on provisional US patent application 63/035,739 (assigned to LanzaTech) related to integration of acetone and isopropanol biosynthesis gene variants that incorporates discoveries incorporated in this manuscript. R.N. is an inventor on provisional US patent application 63/083,257 (assigned to LanzaTech) related to expressing multiple copies of acetone and isopropanol biosynthesis gene variants that incorporates discoveries incorporated in this manuscript. M.C.J. and A.S.K. are co-inventors on a US provisional patent application that incorporates discoveries described in this manuscript. Their interests are reviewed and managed by Northwestern University in accordance with their conflict of interest policies. All other authors declare no competing interests.
