Gu, Jiacheng https://orcid.org/0000-0003-1543-9684
Iyer, Abhishek
Wesley, Ben
Taglialatela, Angelo
Leuzzi, Giuseppe https://orcid.org/0000-0002-2211-790X
Hangai, Sho
Decker, Aubrianna https://orcid.org/0000-0002-0646-1815
Gu, Ruoyu
Klickstein, Naomi
Shuai, Yuanlong
Jankovic, Kristina
Parker-Burns, Lucy
Jin, Yinuo https://orcid.org/0000-0003-1889-8587
Zhang, Jia Yi
Hong, Justin https://orcid.org/0000-0003-2115-9101
Niu, Xiang
Costa, Jonathon A.
Pezet, Mikael G.
Chou, Jacqueline https://orcid.org/0000-0003-4553-4914
Chen, Cao ‘Claire’ https://orcid.org/0009-0003-2441-4662
Paiva, Margaret https://orcid.org/0009-0004-9094-6090
Snoeck, Hans-Willem https://orcid.org/0000-0001-8375-995X
Landau, Dan A. https://orcid.org/0000-0003-2346-9541
Azizi, Elham https://orcid.org/0000-0001-5059-6971
Chan, Edmond M.
Ciccia, Alberto https://orcid.org/0000-0003-4789-6564
Gaublomme, Jellert T. https://orcid.org/0000-0002-1266-052X
Funding for this research was provided by:
U.S. Department of Health & Human Services | NIH | National Cancer Institute (1DP2CA281605, 5R01CA197774-04, 5R01CA227450-04)
U.S. Department of Health & Human Services | NIH | National Human Genome Research Institute (1R21HG012639-01A1, 1R01HG012875-01)
Cancer Research Institute (Lloyd J. Old STAR award)
Article History
Received: 18 December 2023
Accepted: 12 August 2024
First Online: 7 October 2024
Change Date: 5 March 2025
Change Type: Correction
Change Details: A Correction to this paper has been published:
Change Details: https://doi.org/10.1038/s41587-025-02594-z
Competing interests
: Columbia University has filed a patent application related to this work, for which J.T.G. is an inventor. E.M.C.ʼs laboratory receives support from Novartis. D.A.L. has served as a consultant for AbbVie, AstraZeneca and Illumina and is on the scientific advisory boards of Mission Bio, Pangea, Alethiomics and C2i Genomics. D.A.L. has also received prior research funding from Bristol Myers Squibb, 10x Genomics, Ultima Genomics and Illumina, all unrelated to the current study. The remaining authors declare no competing interests.
: All human iPSCs and embyonic stem cells (ESCs) used in this study were previously generated and reported to be derived from material obtained under informed consent and appropriate ethical approvals. The human ESC (RUES2) is approved by the National Institutes of Health (NIH) Intramural Embryonic Stem Cell Research Oversight Committee. Animal care and experimental procedures were performed in accordance with the NIH Guide for the Care and Use of Laboratory Animals and were approved by the Columbia University Institutional Animal Care and Use Committee (protocol AC-AABT8654).