Witten, Jacob https://orcid.org/0000-0003-0037-5999
Raji, Idris https://orcid.org/0000-0001-5697-6422
Manan, Rajith S. https://orcid.org/0000-0001-7081-0138
Beyer, Emily
Bartlett, Sandra
Tang, Yinghua
Ebadi, Mehrnoosh https://orcid.org/0000-0001-5832-3425
Lei, Junying
Nguyen, Dien https://orcid.org/0009-0000-9229-4154
Oladimeji, Favour
Jiang, Allen Yujie https://orcid.org/0000-0002-9826-5976
MacDonald, Elise https://orcid.org/0000-0001-6132-1391
Hu, Yizong
Mughal, Haseeb
Self, Ava
Collins, Evan https://orcid.org/0000-0003-0774-6975
Yan, Ziying https://orcid.org/0000-0001-8210-5567
Engelhardt, John F. https://orcid.org/0000-0003-2389-9277
Langer, Robert https://orcid.org/0000-0003-4255-0492
Anderson, Daniel G. https://orcid.org/0000-0001-5629-4798
Funding for this research was provided by:
U.S. Department of Health & Human Services | National Institutes of Health (HL162564-02, R61AI161805, HL162564-02, HL162564-02, HL152960, DK054759, 75N92019C00010, HL152960, DK054759, 75N92019C00010, HL152960, DK054759, 75N92019C00010, HL152960, DK054759, 75N92019C00010, HL152960, DK054759, 75N92019C00010)
Alpha-1 Foundation
U.S. Department of Health & Human Services | NIH | National Cancer Institute (5P30-CA14051)
Sanofi (N/a, n/a, n/a)
Cystic Fibrosis Foundation (WITTEN19XX0, 004831F5222)
Article History
Received: 18 March 2024
Accepted: 29 October 2024
First Online: 10 December 2024
Competing interests
: J.W., I.R. and D.G.A. have filed a patent for the 4CR ketone biodegradable lipid library described herein and J.W., R.S.M. and D.G.A. have filed a patent for the branched-ester library described herein. Z.Y. and J.F.E. are consultants for Spirovant Sciences. D.G.A. receives research funding from Sanofi/Translate Bio and is a Founder of oRNA Tx. R.L. is a co-founder and board of director of Moderna. He also serves on the board and has equity in Particles For Humanity. For a list of entities with which R.L. is, or has been recently involved compensated or uncompensated, see . The other authors declare no competing interests.