Ren, Diqiu
Wang, Shangshang
Yamada, Keisuke https://orcid.org/0000-0003-1256-9299
Liu, Yuqiao https://orcid.org/0000-0001-8868-9022
Hapke, Robert
Alpsoy, Aktan https://orcid.org/0000-0002-8940-8277
Ho, Yugong
Zhang, Canjing
Lan, Yemin
Zhang, Shuo
Milazzo, Joseph P.
Lohia, Ruchi https://orcid.org/0000-0002-3496-8197
BerrĂos, Kiara N.
Li, Yongjun https://orcid.org/0000-0002-3618-6041
Weber, Evan W.
Li, Qin
Vakoc, Christopher R. https://orcid.org/0000-0002-1158-7180
Minn, Andy J.
Kohli, Rahul M. https://orcid.org/0000-0002-7689-5678
Shi, Junwei https://orcid.org/0000-0002-8427-6316
Funding for this research was provided by:
U.S. Department of Health & Human Services | NIH | National Cancer Institute (CA258904)
St. Jude Children’s Research Hospital Collaborative Research Consortium Mark Foundation for Cancer Research
Mark Foundation for Cancer Research
U.S. Department of Health & Human Services | NIH | National Institute of General Medical Sciences (GM138908)
Article History
Received: 27 January 2025
Accepted: 3 March 2026
First Online: 15 April 2026
Competing interests
: C.R.V. has received consulting fees from Flare Therapeutics, Roivant Sciences and C4 Therapeutics; has served on the advisory boards of KSQ Therapeutics, Syros Pharmaceuticals and Treeline Biosciences; has received research funding from Boehringer-Ingelheim and Treeline Biosciences and owns a stock option from Treeline Biosciences. A.J.M. is a project member of the Parker Institute for Cancer Immunotherapy and has received research funding from Merck. He has also received honoraria and travel support from Merck, AstraZeneca and Pfizer. He is a scientific consultant for Takeda, Xilio, H3 Biomedicine and Related Sciences. A.J.M. is an inventor on patents related to the IFN pathway and on a filed patent related to modified chimeric antigen receptor T cells. R.M.K. is on the Scientific Advisory Board for Life Edit. The University of Pennsylvania has filed patents on seBEs with J.S., R.M.K. and K.N.B. as inventors.