,
Tin, Adrienne https://orcid.org/0000-0002-4207-5866
,
,
Marten, Jonathan https://orcid.org/0000-0001-6916-2014
Halperin Kuhns, Victoria L.
Li, Yong https://orcid.org/0000-0003-2651-8791
Wuttke, Matthias https://orcid.org/0000-0003-3420-5082
Kirsten, Holger https://orcid.org/0000-0002-3126-7950
Sieber, Karsten B.
Qiu, Chengxiang https://orcid.org/0000-0002-6346-8669
Gorski, Mathias
Yu, Zhi
Giri, Ayush https://orcid.org/0000-0002-7786-4670
Sveinbjornsson, Gardar
Li, Man https://orcid.org/0000-0002-3839-0281
Chu, Audrey Y.
Hoppmann, Anselm
O’Connor, Luke J. https://orcid.org/0000-0003-2730-9668
Prins, Bram
Nutile, Teresa
Noce, Damia
Akiyama, Masato
Cocca, Massimiliano
Ghasemi, Sahar
van der Most, Peter J. https://orcid.org/0000-0001-8450-3518
Horn, Katrin https://orcid.org/0000-0002-5307-6936
Xu, Yizhe
Fuchsberger, Christian
Sedaghat, Sanaz
Afaq, Saima
Amin, Najaf
Ärnlöv, Johan
Bakker, Stephan J. L.
Bansal, Nisha
Baptista, Daniela
Bergmann, Sven https://orcid.org/0000-0002-6785-9034
Biggs, Mary L.
Biino, Ginevra https://orcid.org/0000-0002-9936-946X
Boerwinkle, Eric
Bottinger, Erwin P.
Boutin, Thibaud S.
Brumat, Marco https://orcid.org/0000-0003-3268-039X
Burkhardt, Ralph
Campana, Eric
Campbell, Archie https://orcid.org/0000-0003-0198-5078
Campbell, Harry
Carroll, Robert J.
Catamo, Eulalia
Chambers, John C.
Ciullo, Marina
Concas, Maria Pina https://orcid.org/0000-0003-3598-2537
Coresh, Josef https://orcid.org/0000-0002-4598-0669
Corre, Tanguy
Cusi, Daniele
Felicita, Sala Cinzia https://orcid.org/0000-0003-2514-2075
de Borst, Martin H. https://orcid.org/0000-0002-4127-8733
De Grandi, Alessandro
de Mutsert, Renée
de Vries, Aiko P. J.
Delgado, Graciela
Demirkan, Ayşe
Devuyst, Olivier https://orcid.org/0000-0003-3744-4767
Dittrich, Katalin
Eckardt, Kai-Uwe
Ehret, Georg https://orcid.org/0000-0002-5730-0675
Endlich, Karlhans https://orcid.org/0000-0001-6052-6061
Evans, Michele K.
Gansevoort, Ron T.
Gasparini, Paolo
Giedraitis, Vilmantas https://orcid.org/0000-0003-3423-2021
Gieger, Christian
Girotto, Giorgia https://orcid.org/0000-0003-4507-6589
Gögele, Martin
Gordon, Scott D. https://orcid.org/0000-0001-7623-328X
Gudbjartsson, Daniel F. https://orcid.org/0000-0002-5222-9857
Gudnason, Vilmundur https://orcid.org/0000-0001-5696-0084
Haller, Toomas
Hamet, Pavel
Harris, Tamara B.
Hayward, Caroline https://orcid.org/0000-0002-9405-9550
Hicks, Andrew A. https://orcid.org/0000-0001-6320-0411
Hofer, Edith
Holm, Hilma
Huang, Wei
Hutri-Kähönen, Nina
Hwang, Shih-Jen
Ikram, M. Arfan https://orcid.org/0000-0003-0372-8585
Lewis, Raychel M.
Ingelsson, Erik https://orcid.org/0000-0003-2256-6972
Jakobsdottir, Johanna
Jonsdottir, Ingileif https://orcid.org/0000-0001-8339-150X
Jonsson, Helgi
Joshi, Peter K. https://orcid.org/0000-0002-6361-5059
Josyula, Navya Shilpa https://orcid.org/0000-0003-2782-8812
Jung, Bettina
Kähönen, Mika
Kamatani, Yoichiro https://orcid.org/0000-0001-8748-5597
Kanai, Masahiro https://orcid.org/0000-0001-5165-4408
Kerr, Shona M.
Kiess, Wieland
Kleber, Marcus E. https://orcid.org/0000-0003-0663-7275
Koenig, Wolfgang https://orcid.org/0000-0002-2064-9603
Kooner, Jaspal S.
Körner, Antje
Kovacs, Peter https://orcid.org/0000-0002-0290-5423
Krämer, Bernhard K.
Kronenberg, Florian https://orcid.org/0000-0003-2229-1120
Kubo, Michiaki
Kühnel, Brigitte
La Bianca, Martina
Lange, Leslie A.
Lehne, Benjamin
Lehtimäki, Terho
Liu, Jun https://orcid.org/0000-0001-5288-3042
Loeffler, Markus
Loos, Ruth J. F. https://orcid.org/0000-0002-8532-5087
Lyytikäinen, Leo-Pekka https://orcid.org/0000-0002-7200-5455
Magi, Reedik
Mahajan, Anubha https://orcid.org/0000-0001-5585-3420
Martin, Nicholas G. https://orcid.org/0000-0003-4069-8020
März, Winfried
Mascalzoni, Deborah
Matsuda, Koichi
Meisinger, Christa
Meitinger, Thomas
Metspalu, Andres https://orcid.org/0000-0002-3718-796X
Milaneschi, Yuri
O’Donnell, Christopher J.
Wilson, Otis D.
Gaziano, J. Michael
Mishra, Pashupati P.
Mohlke, Karen L. https://orcid.org/0000-0001-6721-153X
Mononen, Nina
Montgomery, Grant W. https://orcid.org/0000-0002-4140-8139
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Müller-Nurasyid, Martina https://orcid.org/0000-0003-3793-5910
Nadkarni, Girish N.
Nalls, Mike A.
Nauck, Matthias
Nikus, Kjell
Ning, Boting
Nolte, Ilja M. https://orcid.org/0000-0001-5047-4077
Noordam, Raymond
O’Connell, Jeffrey R.
Olafsson, Isleifur
Padmanabhan, Sandosh
Penninx, Brenda W. J. H.
Perls, Thomas
Peters, Annette
Pirastu, Mario
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Pistis, Giorgio
Polasek, Ozren
Ponte, Belen
Porteous, David J.
Poulain, Tanja
Preuss, Michael H. https://orcid.org/0000-0001-5266-8465
Rabelink, Ton J.
Raffield, Laura M. https://orcid.org/0000-0002-7892-193X
Raitakari, Olli T.
Rettig, Rainer
Rheinberger, Myriam
Rice, Kenneth M. https://orcid.org/0000-0002-3071-7278
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Ruggiero, Daniela
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Saba, Yasaman
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Schmidt, Reinhold
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Stumvoll, Michael
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Thiery, Joachim
Thio, Chris H. L. https://orcid.org/0000-0003-2623-7172
Thorsteinsdottir, Unnur
Toniolo, Daniela
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van der Harst, Pim https://orcid.org/0000-0002-2713-686X
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Vollenweider, Peter
Waeber, Gerard
Waldenberger, Melanie
Whitfield, John B. https://orcid.org/0000-0002-1103-0876
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Zonderman, Alan B.
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Wilson, James G.
Pendergrass, Sarah A.
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Parsa, Afshin
Pramstaller, Peter P.
Psaty, Bruce M.
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Snieder, Harold https://orcid.org/0000-0003-1949-2298
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Scholz, Markus https://orcid.org/0000-0002-4059-1779
Heid, Iris M.
Hung, Adriana M. https://orcid.org/0000-0002-3203-1608
Teumer, Alexander
Pattaro, Cristian
Woodward, Owen M. https://orcid.org/0000-0001-9514-2180
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Funding for this research was provided by:
U.S. Department of Health & Human Services | NIH | National Institute of Arthritis and Musculoskeletal and Skin Diseases (R01AR073178-01A1)
Deutsche Forschungsgemeinschaft (KO 3598/4-1)
Deutsche Forschungsgemeinschaft (CRC 1140, project number 246781735)
EC | European Regional Development Fund
National Health and Medical Research Council (NHMRC) Fellowship Schemes
Dutch Science Organization
American Heart Association (Postdoctoral Fellowship (17POST3650016))
Nederlandse Organisatie voor Wetenschappelijk Onderzoek (016.186.125)
U.S. Department of Health & Human Services | NIH | National Institute of General Medical Sciences (U54GM115428)
Article History
Received: 17 January 2019
Accepted: 27 August 2019
First Online: 2 October 2019
Competing interests
: D.O.M.-K. works as a part-time clinical research consultant for METABOLON. B.W.J.H.P. has received research funding (unrelated to the work reported in this article) from Jansen Research and Boehringer Ingelheim. K.B.S is full-time employee of GlaxoSmithKline. G.S., D.F.G., I.J., H.H., P.S., U.T. and K.Stefansson are full time employees of deCODE genetics and Amgen. A.Y.C. is an employee of Merck & Co. W.Koenig received modest consultation fees for advisory board meetings from Amgen, DalCor Pharmaceuticals, Kowa, Novartis, Pfizer and Sanofi, and modest personal fees for lectures from Amgen, AstraZeneca, Novartis, Pfizer and Sanofi. D.C. is scientific consultant for Bio4Dreams. W.M. is employed by Synlab Services GmbH and holds shares of Synlab Holding Deutschland GmbH. M.A.N.’s participation in this project is supported by a consulting contract between Data Tecnica International, the National Institute on Aging and NIH, and consults or has consulted during this time for Lysosomal Therapeutics, Neuron23, Illumina, the Michael J. Fox Foundation and the University of California Healthcare. O.P. is an owner of Gen-info. K.Ho has disclosed a research and financial relationship with Sanofi Genzyme. B.M.P. serves on the Data and Safety Monitoring Board of a clinical trial funded by the manufacturer (Zoll Lifecor) and on the Steering Committee of the Yale Open Data Access Project funded by Johnson & Johnson. A.S.B. received grants from MSD, Pfizer, Novartis, Biogen and Bioverativ and personal fees from Novartis. F.R. is a scientific consultant for ePhood. M.Scholz consults for and received grant support not related to this project from Merck Serono. A.Köttgen received grant support not related to this project from Grünenthal. The other authors declare no competing interests.