Dharia, Neekesh V. https://orcid.org/0000-0001-5048-067X
Kugener, Guillaume https://orcid.org/0000-0002-4697-2847
Guenther, Lillian M. https://orcid.org/0000-0002-5906-7504
Malone, Clare F.
Durbin, Adam D. https://orcid.org/0000-0002-5472-9847
Hong, Andrew L. https://orcid.org/0000-0003-0374-1667
Howard, Thomas P. https://orcid.org/0000-0002-3438-2831
Bandopadhayay, Pratiti
Wechsler, Caroline S.
Fung, Iris
Warren, Allison C.
Dempster, Joshua M. https://orcid.org/0000-0002-3634-9576
Krill-Burger, John M. https://orcid.org/0000-0001-9614-4671
Paolella, Brenton R. https://orcid.org/0000-0003-3394-828X
Moh, Phoebe
Jha, Nishant https://orcid.org/0000-0001-5182-9255
Tang, Andrew
Montgomery, Philip https://orcid.org/0000-0002-2633-1081
Boehm, Jesse S. https://orcid.org/0000-0002-6795-6336
Hahn, William C. https://orcid.org/0000-0003-2840-9791
Roberts, Charles W. M. https://orcid.org/0000-0003-1135-1896
McFarland, James M. https://orcid.org/0000-0001-9978-480X
Tsherniak, Aviad https://orcid.org/0000-0002-3797-1877
Golub, Todd R. https://orcid.org/0000-0003-0113-2403
Vazquez, Francisca https://orcid.org/0000-0002-2857-4685
Stegmaier, Kimberly https://orcid.org/0000-0003-0218-7895
Funding for this research was provided by:
U.S. Department of Health & Human Services | NIH | National Cancer Institute (R35 CA210030, R01 CA204915, P01 CA217959, R00CA201592, U01 CA176058)
St. Baldrick’s Foundation (Robert J. Arceci Innovation Award, Julia’s Legacy of Hope Fellow)
Damon Runyon Cancer Research Foundation (PST-20-18, DRSG-24-18)
Rally Foundation
Boston Children’s Hospital
U.S. Department of Health & Human Services | National Institutes of Health (F32CA243266, T32GM007753, T32GM007226)
Alex’s Lemonade Stand Foundation for Childhood Cancer
CureSearch for Children’s Cancer
American Society of Clinical Oncology
American Cancer Society (MRSG-18-202-01)
United States Department of Defense | United States Army | Army Medical Command | Congressionally Directed Medical Research Programs (W81XWH-19-1-0281)
Pediatric Brain Tumor Foundation
Four C’s Fund PMC Team Eradicate Team Sciarappa Strong (Jimmy Fund Walk) Alexandra Simpson Pediatric Research Fund
Helen Gurley Brown Presidential Initiative Fellowship
Team Sciarappa Strong
Jared Branfman Sunflowers for Life Fund The Isabel V Marxuach Fund for Medulloblastoma Research
NBTII Foundation
Alexandra Simpson Pediatric Research Fund
Slim Initiative in Genomic Medicine for the Americas (SIGMA), a joint U.S-Mexico project funded by the Carlos Slim Foundation Walter and Marina Bornhorst
Article History
Received: 21 October 2020
Accepted: 16 February 2021
First Online: 22 March 2021
Competing interests
: N.V.D. is a current employee of Genentech, Inc., a member of the Roche Group. P.B. receives funding from the Novartis Institute of BioMedical Research for an unrelated project and serves as a consultant for QED Therapeutics. W.C.H. is a consultant for Thermo Fisher, Solvasta Ventures, MPM Capital, KSQ Therapeutics, iTeos, Tyra Biosciences, Frontier Medicines, Paraxel and Jubilant Therapeutics. A. Tsherniak is a consultant for Tango Therapeutics. T.R.G. receives research funding unrelated to this project from Bayer HealthCare, Calico Life Sciences and Novo Ventures. T.R.G. was formerly a consultant and equity holder in Foundation Medicine, which was acquired by Roche. T.R.G. is a consultant to GlaxoSmithKline and is a founder and equity holder of Sherlock Biosciences and FORMA Therapeutics. F.V. receives research support from Novo Ventures unrelated to this project. K.S. has funding from the Novartis Institute of BioMedical Research, consults for and has stock options in Auron Therapeutics and served as an advisor for Kronos Bio. The remaining authors declare no competing interests.