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Authors
Pirruccello, James P. https://orcid.org/0000-0001-6088-4037
Di Achille, Paolo https://orcid.org/0000-0001-9256-0678
Nauffal, Victor https://orcid.org/0000-0001-7199-299X
Nekoui, Mahan https://orcid.org/0000-0001-7466-4801
Friedman, Samuel F.
Klarqvist, Marcus D. R. https://orcid.org/0000-0001-7630-2708
Chaffin, Mark D. https://orcid.org/0000-0002-1234-5562
Weng, Lu-Chen https://orcid.org/0000-0003-1475-4930
Cunningham, Jonathan W. https://orcid.org/0000-0003-4481-7867
Khurshid, Shaan
Roselli, Carolina https://orcid.org/0000-0001-5267-6756
Lin, Honghuang https://orcid.org/0000-0003-3043-3942
Koyama, Satoshi
Ito, Kaoru https://orcid.org/0000-0003-1843-773X
Kamatani, Yoichiro
Komuro, Issei
,
Matsuda, Koichi
Yamanashi, Yuji
Furukawa, Yoichi
Morisaki, Takayuki
Murakami, Yoshinori
Kamatani, Yoichiro
Mutu, Kaori
Nagai, Akiko
Obara, Wataru
Yamaji, Ken
Takahashi, Kazuhisa
Asai, Satoshi
Takahashi, Yasuo
Suzuki, Takao
Sinozaki, Nobuaki
Yamaguchi, Hiroki
Minami, Shiro
Murayama, Shigeo
Yoshimori, Kozo
Nagayama, Satoshi
Obata, Daisuke
Higashiyama, Masahiko
Masumoto, Akihide
Koretsune, Yukihiro
Jurgens, Sean J. https://orcid.org/0000-0002-1605-9782
Benjamin, Emelia J. https://orcid.org/0000-0003-4076-2336
Batra, Puneet https://orcid.org/0000-0001-6822-0593
Natarajan, Pradeep https://orcid.org/0000-0001-8402-7435
Ng, Kenney https://orcid.org/0000-0003-0792-070X
Hoffmann, Udo
Lubitz, Steven A. https://orcid.org/0000-0002-9599-4866
Ho, Jennifer E. https://orcid.org/0000-0002-7987-4768
Lindsay, Mark E. https://orcid.org/0000-0001-6724-7938
Philippakis, Anthony A.
Ellinor, Patrick T. https://orcid.org/0000-0002-2067-0533
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Funding
Funding for this research was provided by:
Fondation Leducq (14CVD01)
U.S. Department of Health & Human Services | NIH | National Heart, Lung, and Blood Institute (1RO1HL092577, R01HL128914, K24HL105780, K08HL159346, 5T32HL007604, T32HL007208, 1R01HL139731, R01HL134893, R01HL140224, R01HL128914, 2R01HL092577, 1R01HL141434)
Sarnoff Foundation - Scholar Award John S LaDue Memorial Fellowship
The Fredman Fellowship for Aortic Disease The Toomey Fund for Aortic Dissection Research
Japan Agency for Medical Research and Development (JP20km0405209, JP20ek0109487, JP20km0405209, JP20ek0109487, JP20km0405209, JP20ek0109487)
Hartstichting
American Heart Association (18SFRN34110082)
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Article History
Received: 5 February 2021
Accepted: 26 April 2022
First Online: 13 June 2022
Competing interests
: J.P.P. has served as a consultant for Maze Therapeutics. P.B. is supported by grants from Bayer AG and IBM applying machine learning in cardiovascular disease. S.A.L. receives sponsored research support from Bristol Myers Squibb/Pfizer, Bayer AG, Boehringer Ingelheim and Fitbit, has consulted for Bristol Myers Squibb/Pfizer and Bayer AG and participates in a research collaboration with IBM. K.N. is employed by IBM Research. J.E.H. is supported by a grant from Bayer AG focused on machine learning and cardiovascular disease and a research grant from Gilead Sciences. J.E.H. has received research supplies from EcoNugenics. A.A.P. is employed as a Venture Partner at GV; he is also supported by a grant from Bayer AG to the Broad Institute focused on machine learning for clinical trial design. P.T.E. received sponsored research support from Bayer AG and IBM Research. P.T.E. has also served on advisory boards or consulted for Bayer AG, Quest Diagnostics, MyoKardia and Novartis. P.N. reports investigator-initated grants from Amgen, Apple, AstraZeneca, Boston Scientific, and Novartis, personal fees from Apple, AstraZeneca, Blackstone Life Sciences, Foresite Labs, Novartis, Roche / Genentech, is a co-founder of TenSixteen Bio, is a shareholder of geneXwell and TenSixteen Bio, and spousal employment at Vertex, all unrelated to the present work. The Broad Institute has filed for a patent on an invention from P.T.E., M.E.L. and J.P.P. related to a genetic risk predictor for aortic disease. All remaining authors report no competing interests.
