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Single-cell genome sequencing of human neurons identifies somatic point mutation and indel enrichment in regulatory elements

Crossref DOI link: https://doi.org/10.1038/s41588-022-01180-2

Published Online: 2022-09-26

Published Print: 2022-10

Update policy: https://doi.org/10.1007/springer_crossmark_policy

Authors

Luquette, Lovelace J. http://orcid.org/0000-0001-6968-9043
Miller, Michael B. http://orcid.org/0000-0002-6205-3314
Zhou, Zinan

Bohrson, Craig L.

Zhao, Yifan http://orcid.org/0000-0003-4829-1428
Jin, Hu http://orcid.org/0000-0002-8657-5686
Gulhan, Doga

Ganz, Javier http://orcid.org/0000-0002-2370-9819
Bizzotto, Sara http://orcid.org/0000-0001-6644-0306
Kirkham, Samantha http://orcid.org/0000-0002-5444-6636
Hochepied, Tino

Libert, Claude

Galor, Alon

Kim, Junho http://orcid.org/0000-0003-3513-401X
Lodato, Michael A.

Garaycoechea, Juan I.

Gawad, Charles http://orcid.org/0000-0002-4728-8203
West, Jay

Walsh, Christopher A. http://orcid.org/0000-0002-0156-2238
Park, Peter J. http://orcid.org/0000-0001-9378-960X
Funding

Funding for this research was provided by:

U.S. Department of Health & Human Services | NIH | National Institute of Neurological Disorders and Stroke (R01NS032457, R01NS032457)

U.S. Department of Health & Human Services | NIH | National Institute of Mental Health (U01MH106883, U01MH106883)

U.S. Department of Health & Human Services | NIH | National Human Genome Research Institute (T32HG002295)

U.S. Department of Health & Human Services | NIH | National Institute on Aging (AG065502, R00AG054748, R01AG070921)

U.S. Department of Health & Human Services | NIH | National Heart, Lung, and Blood Institute (HL007627)

BrightFocus Foundation (A20201292F)

Doris Duke Charitable Foundation (2021183)

The Brigham and Women’s Hospital Program for Interdisciplinary Neuroscience through a gift from Lawrence and Tiina Rand.

PRMRP Discovery Award and the Edward R. and Anne G. Lefler Center postdoctoral fellowship.

The Allen Discovery Center program, a Paul G. Allen Frontiers Group advised program of the Paul G. Allen Family Foundation (C.A.W.). C.A.W. is an Investigator of the Howard Hughes Medical Institute.
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Text and Data Mining valid from 2022-09-26

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Article History

Received: 23 November 2020

Accepted: 4 August 2022

First Online: 26 September 2022

Competing interests

: The authors declare the following competing interests: C.G. is Director and cofounder and J.W. is CEO and cofounder of Bioskryb, Inc., the manufacturer of PTA kits used in the present study. C.A.W. is a consultant for Maze Therapeutics (cash, equity), Third Rock Ventures (cash) and Flagship Pioneering (cash), none of which have any relevance to the present study. The remaining authors declare no competing interests.

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