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Authors
Li, Xihao https://orcid.org/0000-0001-8151-0106
Quick, Corbin https://orcid.org/0000-0001-7199-2930
Zhou, Hufeng
Gaynor, Sheila M. https://orcid.org/0000-0002-7869-5223
Liu, Yaowu
Chen, Han
Selvaraj, Margaret Sunitha https://orcid.org/0000-0002-2751-9254
Sun, Ryan
Dey, Rounak https://orcid.org/0000-0002-6540-8280
Arnett, Donna K. https://orcid.org/0000-0003-2219-657X
Bielak, Lawrence F. https://orcid.org/0000-0002-3443-8030
Bis, Joshua C.
Blangero, John https://orcid.org/0000-0001-6250-5723
Boerwinkle, Eric
Bowden, Donald W.
Brody, Jennifer A. https://orcid.org/0000-0001-8509-148X
Cade, Brian E. https://orcid.org/0000-0003-1424-0673
Correa, Adolfo
Cupples, L. Adrienne https://orcid.org/0000-0003-0273-7965
Curran, Joanne E. https://orcid.org/0000-0002-6898-155X
de Vries, Paul S.
Duggirala, Ravindranath
Freedman, Barry I. https://orcid.org/0000-0003-0275-5530
Göring, Harald H. H.
Guo, Xiuqing https://orcid.org/0000-0002-5264-5068
Haessler, Jeffrey
Kalyani, Rita R.
Kooperberg, Charles https://orcid.org/0000-0002-7986-8560
Kral, Brian G. https://orcid.org/0000-0001-9493-2084
Lange, Leslie A.
Manichaikul, Ani
Martin, Lisa W. https://orcid.org/0000-0003-4352-0914
McGarvey, Stephen T. https://orcid.org/0000-0003-1233-6970
Mitchell, Braxton D.
Montasser, May E. https://orcid.org/0000-0002-9558-5456
Morrison, Alanna C. https://orcid.org/0000-0001-6381-4296
Naseri, Take
O’Connell, Jeffrey R.
Palmer, Nicholette D. https://orcid.org/0000-0001-8883-2511
Peyser, Patricia A.
Psaty, Bruce M.
Raffield, Laura M.
Redline, Susan
Reiner, Alexander P. https://orcid.org/0000-0002-1427-4470
Reupena, Muagututi’a Sefuiva
Rice, Kenneth M. https://orcid.org/0000-0002-3071-7278
Rich, Stephen S. https://orcid.org/0000-0003-3872-7793
Sitlani, Colleen M.
Smith, Jennifer A. https://orcid.org/0000-0002-3575-5468
Taylor, Kent D.
Vasan, Ramachandran S. https://orcid.org/0000-0001-7357-5970
Willer, Cristen J. https://orcid.org/0000-0001-5645-4966
Wilson, James G.
Yanek, Lisa R. https://orcid.org/0000-0001-7117-1075
Zhao, Wei https://orcid.org/0000-0001-7388-0692
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Abe, Namiko
Abecasis, Gonçalo
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Ardlie, Kristin
Dan Arking,
Ashley-Koch, Allison
Aslibekyan, Stella
Assimes, Tim
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Balasubramanian, Adithya
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Barnes, Kathleen
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Barwick, Lucas
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Beck, Gerald
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Becker, Lewis
Beer, Rebecca
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Benos, Takis
Bezerra, Marcos
Blackwell, Thomas
Blue, Nathan
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Broome, Jai
Brown, Deborah
Bunting, Karen
Burchard, Esteban
Bustamante, Carlos
Buth, Erin
Cardwell, Jonathan
Carey, Vincent
Carrier, Julie
Carson, April
Carty, Cara
Casaburi, Richard
Casas Romero, Juan P.
Casella, James
Castaldi, Peter
Chaffin, Mark
Chang, Christy
Chang, Yi-Cheng
Chasman, Daniel
Chavan, Sameer
Chen, Bo-Juen
Chen, Wei-Min
Chen, Yii-Der Ida
Cho, Michael
Choi, Seung Hoan
Chuang, Lee-Ming
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Chung, Ren-Hua
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Custer, Brian
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David, Sean
Davis, Colleen
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de las Fuentes, Lisa
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Durda, Jon Peter
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Farek, Jesse
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Fu, Mao
Fullerton, Stephanie M.
Fulton, Lucinda
Gabriel, Stacey
Gan, Weiniu
Gao, Shanshan
Gao, Yan
Gass, Margery
Geiger, Heather
Gelb, Bruce
Geraci, Mark
Germer, Soren
Gerszten, Robert
Ghosh, Auyon
Gibbs, Richard
Gignoux, Chris
Gladwin, Mark
Glahn, David
Gogarten, Stephanie
Gong, Da-Wei
Graw, Sharon
Gray, Kathryn J.
Grine, Daniel
Gross, Colin
Gu, C. Charles
Guan, Yue
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Hall, Michael
Han, Yi
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He, Jiang
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Min, Nancy
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Moll, Matt
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Mychaleckyj, Josyf C.
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Nekhai, Sergei
Nelson, Sarah C.
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Nickerson, Deborah
Nkechinyere, Osuji
North, Kari
O’Connor, Tim
Ochs-Balcom, Heather
Okwuonu, Geoffrey
Pack, Allan
Paik, David T.
Pankow, James
Papanicolaou, George
Parker, Cora
Peralta, Juan Manuel
Perez, Marco
Perry, James
Peters, Ulrike
Phillips, Lawrence S.
Pleiness, Jacob
Pollin, Toni
Post, Wendy
Becker, Julia Powers
Boorgula, Meher Preethi
Preuss, Michael
Qasba, Pankaj
Qiao, Dandi
Qin, Zhaohui
Rafaels, Nicholas
Rajendran, Mahitha
Rao, D. C.
Rasmussen-Torvik, Laura
Ratan, Aakrosh
Reed, Robert
Reeves, Catherine
Regan, Elizabeth
Robillard, Rebecca
Robine, Nicolas
Dan Roden,
Roselli, Carolina
Ruczinski, Ingo
Runnels, Alexi
Russell, Pamela
Ruuska, Sarah
Ryan, Kathleen
Sabino, Ester Cerdeira
Saleheen, Danish
Salimi, Shabnam
Salvi, Sejal
Salzberg, Steven
Sandow, Kevin
Sankaran, Vijay G.
Santibanez, Jireh
Schwander, Karen
Schwartz, David
Sciurba, Frank
Seidman, Christine
Seidman, Jonathan
Sériès, Frédéric
Sheehan, Vivien
Sherman, Stephanie L.
Shetty, Amol
Shetty, Aniket
Sheu, Wayne Hui-Heng
Shoemaker, M. Benjamin
Silver, Brian
Silverman, Edwin
Skomro, Robert
Smith, Albert Vernon
Smith, Josh
Smith, Nicholas
Smith, Tanja
Smoller, Sylvia
Snively, Beverly
Snyder, Michael
Sofer, Tamar
Sotoodehnia, Nona
Stilp, Adrienne M.
Storm, Garrett
Streeten, Elizabeth
Su, Jessica Lasky
Sung, Yun Ju
Sylvia, Jody
Szpiro, Adam
Taliun, Daniel
Tang, Hua
Taub, Margaret
Taylor, Matthew
Taylor, Simeon
Telen, Marilyn
Thornton, Timothy A.
Threlkeld, Machiko
Tinker, Lesley
Tirschwell, David
Tishkoff, Sarah
Tiwari, Hemant
Tong, Catherine
Tracy, Russell
Tsai, Michael
Vaidya, Dhananjay
Van Den Berg, David
VandeHaar, Peter
Vrieze, Scott
Walker, Tarik
Wallace, Robert
Walts, Avram
Wang, Fei Fei
Wang, Heming
Wang, Jiongming
Watson, Karol
Watt, Jennifer
Weeks, Daniel E.
Weinstock, Joshua
Weir, Bruce
Weiss, Scott T.
Weng, Lu-Chen
Wessel, Jennifer
Williams, Kayleen
Williams, L. Keoki
Wilson, Carla
Winterkorn, Lara
Wong, Quenna
Wu, Joseph
Xu, Huichun
Yang, Ivana
Yu, Ketian
Zekavat, Seyedeh Maryam
Zhang, Yingze
Zhao, Snow Xueyan
Zhu, Xiaofeng
Ziv, Elad
Zody, Michael
Zoellner, Sebastian
Rotter, Jerome I.
Natarajan, Pradeep
Peloso, Gina M. https://orcid.org/0000-0002-5355-8636
Li, Zilin https://orcid.org/0000-0003-1521-8945
Lin, Xihong https://orcid.org/0000-0001-7067-7752
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Funding
Funding for this research was provided by:
U.S. Department of Health & Human Services | NIH | National Cancer Institute (R35-CA197449, U19-CA203654)
U.S. Department of Health & Human Services | NIH | National Human Genome Research Institute (U01-HG012064, U01-HG009088)
U.S. Department of Health & Human Services | NIH | National Heart, Lung, and Blood Institute (U01-HL072524, R01-HL104135-04S1, U01-HL054472, U01-HL054473, U01-HL054495, U01-HL054509, R01-HL055673-18S1, R01-HL113323, R01-HL045522, HHSN268201700001I, HHSN268201700002I, HHSN268201700003I, HHSN268201700005I, HHSN268201700004I, R01-HL92301, R01-HL67348, F32-HL085989, R01-HL153805, R03-HL154284, HHSN268201800010I, HHSN268201800011I, HHSN268201800012I, HHSN268201800013I, HHSN268201800014I, HHSN268201800015I, NO1-HC-25195, HHSN268201500001I, R01-HL092577-06S1, R01-HL113323, R01-HL045522, R01-HL113323, R01-HL045522, R01-HL113323, R01-HL045522, HHSN268201500003I, N01-HC-95159, N01-HC-95160, N01-HC-95161, N01-HC-95162, N01-HC-95163, N01-HC-95164, N01-HC-95165, N01-HC-95166, N01-HC-95167, N01-HC-95168, N01-HC-95169, R01-HL071051, R01-HL071205, R01HL071250, R01HL071251, R01HL071258, R01HL071259, HHSN268201600018C, HHSN268201600001C, HHSN268201600002C, HHSN268201600003C, HHSN268201600004C, R01-HL093093, R01-HL133040, U01-HL137181, R01-HL92301, R01-HL67348, F32-HL085989, R35-HL135818, R01-HL113338, HL436801, HHSN268201800001I, U01-HL137162, NO1-HC-25195, HHSN268201500001I, 75N92019D00031, R01-HL092577-06S1, R35-HL135824, U01-HL72518, HL087698, HL49762, HL59684, HL58625, HL071025, HL112064, HHSN268201500003I, N01-HC-95159, N01-HC-95160, N01-HC-95161, N01-HC-95162, N01-HC-95163, N01-HC-95164, N01-HC-95165, N01-HC-95166, N01-HC-95167, N01-HC-95168, N01-HC-95169, R01-HL071051, R01-HL071205, R01HL071250, R01HL071251, R01HL071258, R01HL071259, R01-HL142711, R01-HL127564, R01-HL142711, R01-HL127564, BioData Catalyst Fellowship)
U.S. Department of Health & Human Services | NIH | National Institute of Diabetes and Digestive and Kidney Diseases (U01-DK085524, R01-DK071891, U01-DK085524, U01-DK085524, R01-DK071891, U01-DK085524, DK063491, R01-DK071891, DK063491)
U.S. Department of Health & Human Services | NIH | National Institute of Mental Health (R01-MH078143, R01-MH078111, R01-MH083824, R01-MH078143, R01-MH078111, R01-MH083824, R01-MH078143, R01-MH078111, R01-MH083824, R01-MH078143, R01-MH078111, R01-MH083824)
U.S. Department of Health & Human Services | NIH | National Institute of Neurological Disorders and Stroke (R01-NS058700, R01-NS058700)
U.S. Department of Health & Human Services | NIH | National Institute of Arthritis and Musculoskeletal and Skin Diseases (R01-AR48797, R01-AR48797)
U.S. Department of Health & Human Services | NIH | National Institute on Aging (R01-AG058921, P60-AG10484, R01-AG058921, P60-AG10484)
U.S. Department of Health & Human Services | NIH | National Center for Research Resources (M01-RR07122, UL1RR033176, M01-RR07122, M01-RR000052, UL1RR033176)
The American Diabetes Association
U.S. Department of Health & Human Services | National Institutes of Health (75N92019D00031, 75N92020D00001, 75N92020D00002, 75N92020D00003, 75N92020D00004, 75N92020D00005, 75N92020D00006, 75N92020D00007, 75N92020D00001, 75N92020D00002, 75N92020D00003, 75N92020D00004, 75N92020D00005, 75N92020D00006, 75N92020D00007)
American Heart Association (18CDA34110116)
U.S. Department of Health & Human Services | NIH | National Center for Advancing Translational Sciences (UL1-TR-000040, UL1-TR-001079, UL1-TR-001420, UL1-TR-001881, KL2TR002490, UL1-TR-000040, UL1-TR-001079, UL1-TR-001420, UL1-TR-001881)
The Evans Medical Foundation and the Jay and Louis Coffman Endowment from the Department of Medicine, Boston University School of Medicine
U.S. Department of Health & Human Services | NIH | National Institute of Nursing Research (NR0224103)
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Article History
Received: 16 August 2021
Accepted: 13 October 2022
First Online: 23 December 2022
Competing interests
: S.M.G. is now an employee of Regeneron Genetics Center. For B.D.M., The Amish Research Program receives partial support from Regeneron Pharmaceuticals. M.E.M. reports grant from Regeneron Pharmaceutical unrelated to the present work. B.M.P. serves on the Steering Committee of the Yale Open Data Access Project funded by Johnson & Johnson. L.M.R. is a consultant for the TOPMed Administrative Coordinating Center (through Westat). For S.R., Jazz Pharma, Eli Lilly, Apnimed, unrelated to the present work. The spouse of C.J.W. works at Regeneron Pharmaceuticals. P.N. reports investigator-initiated grants from Amgen, Apple, AstraZeneca, Boston Scientific and Novartis, personal fees from Apple, AstraZeneca, Blackstone Life Sciences, Foresite Labs, Novartis, Roche/Genentech, is a cofounder of TenSixteen Bio, is a shareholder of geneXwell and TenSixteen Bio, and spousal employment at Vertex, all unrelated to the present work. X. Lin is a consultant of AbbVie Pharmaceuticals and Verily Life Sciences. The remaining authors declare no competing interests.
