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Article History
Received: 4 April 2022
Accepted: 5 May 2023
First Online: 12 June 2023
Competing interests
: D.K. is a scientific advisor and reports consulting fees from Bitterroot Bio, unrelated to the present work. C.J.W. is currently employed by Regeneron Pharmaceuticals but was not employed by Regeneron before the initial submission date of this paper. S.A.L. is a consultant for Terumo Aortic and Cerus and a principal investigator for clinical studies sponsored by Terumo Aortic and CytoSorbents. P.N. reports grants from Amgen, Apple, AstraZeneca, Boston Scientific and Novartis; is a consultant for Apple, AstraZeneca, Blackstone Life Sciences, Foresite Labs, Genexwell, Novartis, Roche–Genentech and TenSixteen Bio; is a scientific cofounder of TenSixteen Bio; and reports spousal employment at Vertex, all unrelated to the present work. K.G.A. reports consulting for Sarepta Therapeutics and a research collaboration with Novartis. M.D.R. is on the scientific advisory board for Cipherome. S.M.D. has received research support via the University of Pennsylvania from RenalytixAI and Novo Nordisk. R.D. reports receiving grants from AstraZeneca; grants and non-financial support from Goldfinch Bio; being a scientific cofounder, consultant and equity holder (pending) for Pensieve Health; and is a consultant for Variant Bio, all unrelated to this work. P.T.E. has received sponsored research support from Bayer, IBM Research, Pfizer and Bristol Myers Squibb; he has also consulted for Bayer, Novartis and MyoKardia. All other authors have no competing interests to disclose.