Crossmark

Genome-wide analysis in over 1 million individuals of European ancestry yields improved polygenic risk scores for blood pressure traits

Crossref DOI link: https://doi.org/10.1038/s41588-024-01714-w

Published Online: 2024-04-30

Published Print: 2024-05

Update policy: https://doi.org/10.1007/springer_crossmark_policy

Authors

Keaton, Jacob M.

Kamali, Zoha https://orcid.org/0000-0001-6492-5887
Xie, Tian https://orcid.org/0000-0003-2442-7941
Vaez, Ahmad https://orcid.org/0000-0001-9048-3795
Williams, Ariel

Goleva, Slavina B. https://orcid.org/0000-0001-5177-9286
Ani, Alireza https://orcid.org/0000-0002-7868-3118
Evangelou, Evangelos https://orcid.org/0000-0002-5488-2999
Hellwege, Jacklyn N. https://orcid.org/0000-0001-7479-0920
Yengo, Loic

Young, William J. https://orcid.org/0000-0002-9831-6817
Traylor, Matthew

Giri, Ayush

Zheng, Zhili https://orcid.org/0000-0003-2102-221X
Zeng, Jian

Chasman, Daniel I.

Morris, Andrew P. https://orcid.org/0000-0002-6805-6014
Caulfield, Mark J. https://orcid.org/0000-0001-9295-3594
Hwang, Shih-Jen

Kooner, Jaspal S. https://orcid.org/0000-0003-2086-4837
Conen, David

Attia, John R. https://orcid.org/0000-0001-9800-1308
Morrison, Alanna C. https://orcid.org/0000-0001-6381-4296
Loos, Ruth J. F. https://orcid.org/0000-0002-8532-5087
Kristiansson, Kati

Schmidt, Reinhold

Hicks, Andrew A. https://orcid.org/0000-0001-6320-0411
Pramstaller, Peter P. https://orcid.org/0000-0002-9831-8302
Nelson, Christopher P.

Samani, Nilesh J.

Risch, Lorenz https://orcid.org/0000-0003-2692-6699
Gyllensten, Ulf https://orcid.org/0000-0002-6316-3355
Melander, Olle

Riese, Harriette

Wilson, James F. https://orcid.org/0000-0001-5751-9178
Campbell, Harry

Rich, Stephen S. https://orcid.org/0000-0003-3872-7793
Psaty, Bruce M. https://orcid.org/0000-0002-7278-2190
Lu, Yingchang

Rotter, Jerome I. https://orcid.org/0000-0001-7191-1723
Guo, Xiuqing https://orcid.org/0000-0002-5264-5068
Rice, Kenneth M. https://orcid.org/0000-0002-3071-7278
Vollenweider, Peter

Sundström, Johan

Langenberg, Claudia https://orcid.org/0000-0002-5017-7344
Tobin, Martin D. https://orcid.org/0000-0002-3596-7874
Giedraitis, Vilmantas https://orcid.org/0000-0003-3423-2021
Luan, Jian’an https://orcid.org/0000-0003-3137-6337
Tuomilehto, Jaakko

Kutalik, Zoltan

Ripatti, Samuli https://orcid.org/0000-0002-0504-1202
Salomaa, Veikko https://orcid.org/0000-0001-7563-5324
Girotto, Giorgia https://orcid.org/0000-0003-4507-6589
Trompet, Stella https://orcid.org/0000-0001-5006-0528
Jukema, J. Wouter

van der Harst, Pim

Ridker, Paul M.

Giulianini, Franco

Vitart, Veronique https://orcid.org/0000-0002-4991-3797
Goel, Anuj https://orcid.org/0000-0003-2307-4021
Watkins, Hugh https://orcid.org/0000-0002-5287-9016
Harris, Sarah E. https://orcid.org/0000-0002-4941-5106
Deary, Ian J. https://orcid.org/0000-0002-1733-263X
van der Most, Peter J. https://orcid.org/0000-0001-8450-3518
Oldehinkel, Albertine J. https://orcid.org/0000-0003-3925-3913
Keavney, Bernard D. https://orcid.org/0000-0001-9573-0812
Hayward, Caroline https://orcid.org/0000-0002-9405-9550
Campbell, Archie https://orcid.org/0000-0003-0198-5078
Boehnke, Michael https://orcid.org/0000-0002-6442-7754
Scott, Laura J. https://orcid.org/0000-0002-4886-5084
Boutin, Thibaud https://orcid.org/0000-0003-4754-1675
Mamasoula, Chrysovalanto

Järvelin, Marjo-Riitta

Peters, Annette https://orcid.org/0000-0001-6645-0985
Gieger, Christian https://orcid.org/0000-0001-6986-9554
Lakatta, Edward G. https://orcid.org/0000-0002-4772-0035
Cucca, Francesco https://orcid.org/0000-0002-7414-1995
Hui, Jennie

Knekt, Paul

Enroth, Stefan https://orcid.org/0000-0002-5056-9137
De Borst, Martin H. https://orcid.org/0000-0002-4127-8733
Polašek, Ozren

Concas, Maria Pina

Catamo, Eulalia https://orcid.org/0000-0002-4701-9134
Cocca, Massimiliano https://orcid.org/0000-0002-1127-7596
Li-Gao, Ruifang

Hofer, Edith

Schmidt, Helena https://orcid.org/0000-0001-9773-9992
Spedicati, Beatrice https://orcid.org/0000-0002-7432-4708
Waldenberger, Melanie https://orcid.org/0000-0003-0583-5093
Strachan, David P.

Laan, Maris https://orcid.org/0000-0002-8519-243X
Teumer, Alexander https://orcid.org/0000-0002-8309-094X
Dörr, Marcus

Gudnason, Vilmundur https://orcid.org/0000-0001-5696-0084
Cook, James P.

Ruggiero, Daniela https://orcid.org/0000-0003-3898-7827
Kolcic, Ivana https://orcid.org/0000-0001-7918-6052
Boerwinkle, Eric

Traglia, Michela

Lehtimäki, Terho

Raitakari, Olli T.

Johnson, Andrew D. https://orcid.org/0000-0001-6369-5178
Newton-Cheh, Christopher https://orcid.org/0000-0002-3001-9111
Brown, Morris J. https://orcid.org/0000-0001-8409-1082
Dominiczak, Anna F. https://orcid.org/0000-0003-4913-3608
Sever, Peter J.

Poulter, Neil

Chambers, John C. https://orcid.org/0000-0003-0209-4541
Elosua, Roberto

Siscovick, David

Esko, Tõnu

Metspalu, Andres https://orcid.org/0000-0002-3718-796X
Strawbridge, Rona J. https://orcid.org/0000-0001-8506-3585
Laakso, Markku https://orcid.org/0000-0002-3394-7749
Hamsten, Anders

Hottenga, Jouke-Jan https://orcid.org/0000-0002-5668-2368
de Geus, Eco

Morris, Andrew D.

Palmer, Colin N. A. https://orcid.org/0000-0002-6415-6560
Nolte, Ilja M. https://orcid.org/0000-0001-5047-4077
Milaneschi, Yuri https://orcid.org/0000-0002-3697-6617
Marten, Jonathan

Wright, Alan

Zeggini, Eleftheria https://orcid.org/0000-0003-4238-659X
Howson, Joanna M. M. https://orcid.org/0000-0001-7618-0050
O’Donnell, Christopher J.

Spector, Tim https://orcid.org/0000-0002-9795-0365
Nalls, Mike A. https://orcid.org/0000-0003-0319-4325
Simonsick, Eleanor M.

Liu, Yongmei

van Duijn, Cornelia M. https://orcid.org/0000-0002-2374-9204
Butterworth, Adam S. https://orcid.org/0000-0002-6915-9015
Danesh, John N.

Menni, Cristina https://orcid.org/0000-0001-9790-0571
Wareham, Nicholas J. https://orcid.org/0000-0003-1422-2993
Khaw, Kay-Tee

Sun, Yan V. https://orcid.org/0000-0002-2838-1824
Wilson, Peter W. F. https://orcid.org/0000-0002-5653-7056
Cho, Kelly

Visscher, Peter M. https://orcid.org/0000-0002-2143-8760
Denny, Joshua C. https://orcid.org/0000-0002-3049-7332
,

,

,

van Duijn, Cornelia M.

,

Butterworth, Adam S.

Vaez, Ahmad

Teumer, Alexander

Johnson, Andrew D.

Morris, Andrew D.

Peters, Annette

Goel, Anuj

Campbell, Archie

Keavney, Bernard D.

Hayward, Caroline

Newton-Cheh, Christopher

Nelson, Christopher P.

Chasman, Daniel I.

Levy, Daniel

Ruggiero, Daniela

de Geus, Eco

Hofer, Edith

Zeggini, Eleftheria

Boerwinkle, Eric

Girotto, Giorgia

Warren, Helen R.

Watkins, Hugh

Kolcic, Ivana

Jukema, J. Wouter

Hui, Jennie

Howson, Joanna M. M.

Sundström, Johan

Chambers, John C.

Danesh, John N.

Risch, Lorenz

Caulfield, Mark J.

Laakso, Markku

Tobin, Martin D.

De Borst, Martin H.

Waldenberger, Melanie

Samani, Nilesh J.

Melander, Olle

Raitakari, Olli T.

Polašek, Ozren

Munroe, Patricia B.

Ridker, Paul M.

van der Harst, Pim

Elosua, Roberto

Ripatti, Samuli

Lehtimäki, Terho

Young, William J.

Kamali, Zoha

Kutalik, Zoltan

Levy, Daniel

Edwards, Todd L. https://orcid.org/0000-0003-4318-6119
Munroe, Patricia B. https://orcid.org/0000-0002-4176-2947
Snieder, Harold https://orcid.org/0000-0003-1949-2298
Warren, Helen R. https://orcid.org/0000-0003-0511-1386
License Information

Text and Data Mining valid from 2024-04-30

Version of Record valid from 2024-04-30
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Article History

Received: 1 March 2022

Accepted: 11 March 2024

First Online: 30 April 2024

Competing interests

: The participation of M.A.N. in this project was part of a competitive contract awarded to Data Tecnica International by the National Institutes of Health to support open science research. He also currently serves on the scientific advisory board for Clover Therapeutics and is an advisor to Neuron23 as a data science fellow. B.M.P. serves on the steering committee of the Yale Open Data Access Project funded by Johnson & Johnson. P.V. received an unrestricted grant from GlaxoSmithKline to build the CoLaus study (2003). V.S. has received honoraria for consulting from Novo Nordisk and Sanofi and has ongoing research collaboration with Bayer (all unrelated to this project). R.L. is a part-time consultant of Metabolon. M.J.C. is Chief Scientist for Genomics England, a UK Government company. M. Traylor and J.M.M.H. are employees and stockholders of Novo Nordisk. C.J.O. is currently employed by Novartis Institutes for Biomedical Research (unrelated to this project) and remains credentialed as a ‘without compensation’ researcher with the Veterans Administration. T.S. is co-founder of Zoe Ltd. A.S.B. reports institutional grants from AstraZeneca, Bayer, Biogen, BioMarin, Bioverativ, Novartis, Regeneron and Sanofi. J.N.D. reports grants, personal fees and non-financial support from Merck Sharp & Dohme (MSD), grants, personal fees and non-financial support from Novartis, grants from Pfizer and grants from AstraZeneca outside the submitted work. J.N.D. sits on the International Cardiovascular and Metabolic Advisory Board for Novartis (since 2010); the Steering Committee of UK Biobank (since 2011); the MRC International Advisory Group (ING) member, London (since 2013); the MRC High Throughput Science Omics Panel Member, London (since 2013); the Scientific Advisory Committee for Sanofi (since 2013); the International Cardiovascular and Metabolism Research and Development Portfolio Committee for Novartis; and the AstraZeneca Genomics Advisory Board (2018). E.E was co-founder and has received consultation fees from Open DNA (unrelated to this project). The other authors declare no competing interests.

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