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Authors
Puttick, Clare https://orcid.org/0009-0006-3022-8737
Jones, Thomas P. https://orcid.org/0000-0003-2748-0780
Leung, Michelle M. https://orcid.org/0000-0001-9555-1080
Galvez-Cancino, Felipe https://orcid.org/0000-0001-8417-1891
Liu, Jiali https://orcid.org/0000-0002-9368-4696
Varas-Godoy, Manuel https://orcid.org/0000-0001-5857-4793
Rowan, Andrew
Pich, Oriol https://orcid.org/0000-0002-1956-1882
Martinez-Ruiz, Carlos https://orcid.org/0000-0002-4817-0565
Bentham, Robert
Dijkstra, Krijn K.
Black, James R. M. https://orcid.org/0000-0001-5598-7752
Rosenthal, Rachel
Kanu, Nnennaya https://orcid.org/0000-0001-7232-1952
Litchfield, Kevin https://orcid.org/0000-0002-3725-0914
Salgado, Roberto https://orcid.org/0000-0002-1110-3801
Moore, David A. https://orcid.org/0000-0002-6296-1312
Van Loo, Peter https://orcid.org/0000-0003-0292-1949
Jamal-Hanjani, Mariam
Quezada, Sergio A. https://orcid.org/0000-0002-9763-1700
,
Cheyne, Heather
Khalil, Mohammed
Richardson, Shirley
Cruickshank, Tracey
Lim, Eric
Aerts, Hugo J. W. L.
Kaufmann, Tom L.
Huska, Matthew R.
Naidu, Babu
Wilson, Gareth A.
Rosenthal, Rachel
Rowan, Andrew
Bailey, Chris
Lee, Claudia
Colliver, Emma
Enfield, Katey S. S.
Hill, Mark S.
Angelova, Mihaela
Pich, Oriol
Biswas, Dhruva
Puttick, Clare
Vendramin, Roberto
Murphy, Cian
Zagorulya, Maria
Jones, Thomas P.
Leung, Michelle M.
McGranahan, Nicholas
Castignani, Carla
Cadieux, Elizabeth Larose
Kittel, Jeanette
Haase, Kerstin
Koh, Kexin
Scott, Rachel
Matharu, Gurdeep
Shaw, Jacqui A.
Hackshaw, Allan
Pilotti, Camilla
Leslie, Rachel
Hacker, Anne-Marie
Smith, Sean
Walker, Aoife
Abbosh, Christopher
Richard, Corentin
Naceur-Lombardelli, Cristina
Gimeno-Valiente, Francisco
Thakkar, Krupa
Sunderland, Mariana Werner
Sivakumar, Monica
Kanu, Nnennaya
Usaite, Ieva
Saghafinia, Sadegh
Veeriah, Selvaraju
Vanloo, Sharon
Mussa, Bushra
Magala, Michalina
Keene, Elizabeth
Lim, Emilia L.
Black, James R. sM
Bakir, Maise Al
Huebner, Ariana
Grigoriadis, Kristiana
Karasaki, Takahiro
Frankell, Alexander M.
Hiley, Crispin T.
Ward, Sophia
Harries, Sian
Lucas, Olivia
Moore, David A.
Birkbak, Nicolai J.
Martínez-Ruiz, Carlos
Thol, Kerstin
Bentham, Robert
Liu, Wing Kin
Bunkum, Abigail
Hessey, Sonya
Forster, Martin D.
Lee, Siow Ming
Jamal-Hanjani, Mariam
Karagianni, Despoina
Quezada, Sergio A.
Bola, Supreet Kaur
Litchfield, Kevin
Swanton, Charles
Le Quesne, John
AbdulJabbar, Khalid
Veiga, Catarina
Zaccaria, Simone
Tugwood, Jonathan
Dive, Caroline
Szallasi, Zoltan
Diossy, Miklos
Marafioti, Teresa
Borg, Elaine
Falzon, Mary
Khiroya, Reena
Van Loo, Peter
Peggs, Karl S.
Price, Gillian
Royle, Gary
Collins-Fekete, Charles-Antoine
Papadatos-Pastos, Dionysis
Wilson, James
Ahmad, Tanya
Benafif, Sarah
Cave, Judith
Kerr, Keith M.
Watkins, Thomas B. K.
Salgado, Roberto
Procter, Alexander James
Ahmed, Asia
Taylor, Magali N.
Nair, Arjun
Lawrence, David
Patrini, Davide
Lindsay, Colin R.
Blackhall, Fiona H.
Summers, Yvonne
Krebs, Matthew G.
Nye, Emma
Stone, Richard Kevin
Zhang, Hanyun
Nicod, Jerome
Kirk, Alan
Asif, Mo
Bilancia, Rocco
Kostoulas, Nikos
Whiteley, Jennifer
Thomas, Mathew
Patel, Akshay J.
Chuter, David
MacKenzie, Mairead
Schwarz, Roland F.
Kidd, Andrew
Fraioli, Francesco
Ashford, Paul
Kaplar, Zoltan
Demeulemeester, Jonas
Wilson, Claire
Shackcloth, Michael J.
Janes, Sam M.
Navani, Neal
Thakrar, Ricky M.
Leek, Angela
Hodgkinson, Jack Davies
Totton, Nicola
Paiva-Correia, Antonio
Beck, Stephan
Tanic, Miljana
Dick, Craig
Robinson, Lily
Russell, Peter
De Sousa, Paulo
Jordan, Simon
Rice, Alexandra
Raubenheimer, Hilgardt
Bhayani, Harshil
Ambrose, Lyn
Devaraj, Anand
Chavan, Hemangi
Begum, Sofina
Buderi, Silviu I.
Kaniu, Daniel
Malima, Mpho
Booth, Sarah
Fernandes, Nadia
Shah, Pratibha
Proli, Chiara
Nicholson, Andrew G.
Boleti, Ekaterini
Hewish, Madeleine
Blyth, Kevin G.
Lester, Jason F.
Chaturvedi, Anshuman
Oliveira, Pedro
Brown, Katherine D.
Carter, Mathew
Magness, Alastair
Weeden, Clare E.
Grönroos, Eva
Goldman, Jacki
Escudero, Mickael
Hobson, Philip
Boeing, Stefan
Denner, Tamara
Barbè, Vittorio
Lu, Wei-Ting
Hill, William
Naito, Yutaka
Ramsden, Zoe
Kassiotis, George
Noorani, Imran
Grapa, Anca
Alzetani, Aiman
Yuan, Yinyin
Pan, Xiaoxi
French, Jack
Gilbert, Kayleigh
Dwornik, Angela
Karamani, Angeliki
Chain, Benny
Pearce, David R.
Gálvez-Cancino, Felip
Stavrou, Georgia
Mastrokalos, Gerasimos-Theodoros
Lowe, Helen L.
Matos, Ignacio Garcia
Reading, James L.
Hartley, John A.
Selvaraju, Kayalvizhi
Chen, Kezhong
Ensell, Leah
Shah, Mansi
Litovchenko, Maria
Pawlik, Piotr
Gamble, Samuel
Ung, Seng Kuong Anakin
Spanswick, Victoria
Wu, Yin
Rane, Jayant K.
Al-Sawaf, Othman
Chervova, Olga
Hoogenboom, Emilie Martinoni
Monk, Fleur
Holding, James W.
Choudhary, Junaid
Bhakhri, Kunal
Gorman, Pat
Stephens, Robert C. M.
Pisciella, Maria Chiara
Bandula, Steve
Wong, Yien Ning Sophia
Osman, Aya
Sangha, Mandeesh
Langman, Gerald
Shackleford, Helen
Djearaman, Madava
Middleton, Gary
Chee, Serena
Georg, Patricia
Bajaj, Amrita
Nakas, Apostolos
Sodha-Ramdeen, Azmina
Tufail, Mohamad
Scotland, Molly
Boyles, Rebecca
Rathinam, Sridhar
Marrone, Domenic
Dulloo, Sean
Fennell, Dean A.
Danson, Sarah
Smith, Elaine
Fontaine, Eustace
Granato, Felice
Novasio, Juliette
Rammohan, Kendadai
Joseph, Leena
Bishop, Paul
Shah, Rajesh
Joshi, Vijay
Crosbie, Philip
Swanton, Charles https://orcid.org/0000-0002-4299-3018
McGranahan, Nicholas https://orcid.org/0000-0001-9537-4045
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Article History
Received: 16 December 2022
Accepted: 25 July 2024
First Online: 2 October 2024
Competing interests
: C.P. holds a patent pending in determining HLA disruption (PCT/EP2023/059039). K.K.D. provided consultancy services to Achilles Therapeutics UK. N.K. receives research support from AstraZeneca. K.L. has a patent on InDel burden and CPI response pending and speaker fees from Roche tissue diagnostics, research funding from CRUK TDL–Ono–LifeArc alliance, Genesis Therapeutics and consulting roles with Ellipses Pharma, Monopteros and Kynos Therapeutics. D.A.M. reports speaker fees from Eli Lilly, AstraZeneca and Takeda Pharmaceuticals; consultancy fees from AstraZeneca, Thermo Fisher Scientific, Takeda Pharmaceuticals, Amgen, Janssen, MIM Software, Bristol Myers Squibb and Eli Lilly; and has received educational support from Takeda Pharmaceuticals and Amgen. M.J.-H. has received funding from CRUK, NIH National Cancer Institute, IASLC International Lung Cancer Foundation, Lung Cancer Research Foundation, Rosetrees Trust, UKI NETs and NIHR. M.J-H. has consulted for, and is a member of, the Achilles Therapeutics Scientific Advisory Board and Steering Committee and has received speaker honoraria from Pfizer, Astex Pharmaceuticals, Oslo Cancer Cluster, Bristol Myers Squibb and Genentech. M.J.-.H. is listed as a co-inventor on a European patent application relating to methods to detect lung cancer PCT/US2017/028013). This patent has been licensed to commercial entities, and under terms of employment, M.J.-H. is due a share of any revenue generated from such license(s) and is also listed as a co-inventor on the GB priority patent application (GB2400424.4) with title—Treatment and Prevention of Lung Cancer. C.S. acknowledges grants from AstraZeneca, Boehringer-Ingelheim, Bristol Myers Squibb, Pfizer, Roche-Ventana, Invitae (previously Archer Dx—collaboration in minimal residual disease sequencing technologies), Ono Pharmaceutical and Personalis. He is the chief investigator for the AZ MeRmaiD 1 and 2 clinical trials and is the Steering Committee Chair. He is also the cochief investigator of the NHS Galleri trial funded by GRAIL and a paid member of GRAIL’s Scientific Advisory Board. He receives consultant fees from Achilles Therapeutics (also a SAB member), Bicycle Therapeutics (also a SAB member), Genentech, Medicxi, China Innovation Centre of Roche (CICoR) formerly Roche Innovation Centre—Shanghai, Metabomed (until July 2022), Relay Therapeutics SAB member, Saga Diagnostics SAB member and the Sarah Cannon Research Institute. He has received honoraria from Amgen, AstraZeneca, Bristol Myers Squibb, GlaxoSmithKline, Illumina, MSD, Novartis, Pfizer and Roche-Ventana. He has previously held stock options in Apogen Biotechnologies and GRAIL; currently has stock options in Epic Bioscience, Bicycle Therapeutics, and Relay Therapeutics; and has stock options and is cofounder of Achilles Therapeutics. He declares a patent application for methods to lung cancer (PCT/US2017/028013); targeting neoantigens (PCT/EP2016/059401); identifying patent response to immune checkpoint blockade (PCT/EP2016/071471); methods for lung cancer detection (US20190106751A1); identifying patients who respond to cancer treatment (PCT/GB2018/051912); determining HLA LOH (PCT/GB2018/052004); predicting survival rates of patients with cancer (PCT/GB2020/050221); and methods and systems for tumor monitoring (PCT/EP2022/077987). He is an inventor of a European patent application (PCT/GB2017/053289) relating to assay technology to detect tumor recurrence. This patent has been licensed to a commercial entity, and under their terms of employment, he is due a revenue share of any revenue generated from such license(s). N.M. has stock options in and has consulted for Achilles Therapeutics and holds a European patent in determining HLA LOH (PCT/GB2018/052004), a patent pending in determining HLA disruption (PCT/EP2023/059039), and is a co-inventor to a patent to identify responders to cancer treatment (PCT/GB2018/051912). The remaining authors declare no competing interests.
