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,
Funding for this research was provided by:
British Heart Foundation (AA/18/6/34223, FS/18/65/34186)
DH | National Institute for Health Research (NIHR203328)
More details on funding sources are provided in the Acknowledgements
Article History
Received: 9 October 2023
Accepted: 17 December 2024
First Online: 4 March 2025
Competing interests
: R.T.L. received institutional research support from Pfizer. R.T.L. has served as a paid consultant for Health Lumen and FITFILE. J.S.W. has acted as a consultant for MyoKardia, Pfizer, Foresite Labs and Health Lumen and received institutional support from Bristol Myers Squibb and Pfizer. S.d.D. was supported through grants from AstraZeneca and Roche Molecular Science/DalCor. J.R.K. declares stock ownership in AbbVie, Abbott, Bristol Myers Squibb, Johnson & Johnson, Medtronic, Merck and Pfizer. N.A.M. received speaking honoraria from Amgen and is involved in clinical trials with Ionis, Amgen, Pfizer and Novartis. B.M.P. serves on the Steering Committee of the Yale Open Data Access Project funded by Johnson & Johnson. C.T.R. received honoraria for scientific advisory boards and consulting from Anthos, Bayer, Bristol Myers Squibb, Daiichi Sankyo, Janssen and Pfizer and received institutional research grants from Anthos, AstraZeneca, Daiichi Sankyo, Janssen and Novartis. M.S.S. received substantial research grant support from Abbott Laboratories, Amgen, AstraZeneca, Bayer, Critical Diagnostics, Daiichi Sankyo, Eisai, Genzyme, Gilead, GlaxoSmithKline, Intarcia, Janssen Research and Development, The Medicines Company, MedImmune, Merck, Novartis, Poxel, Pfizer, Quark Pharmaceuticals, Roche Diagnostics and Takeda and has received consulting fees from Alnylam, AstraZeneca, Bristol Myers Squibb, CVS and Amgen. A.A.V. received consultancy fees and/or research support from AnaCardia, AstraZeneca, Bayer, BMS, Boehringer Ingelheim, Corteria, Cytokinetics, Eli Lilly, Moderna, Novartis, Novo Nordisk and Roche Diagnostics. M.-P.D. declares holding equity in Dalcor Pharmaceuticals, unrelated to this work. Members of the TIMI Study Group (ENGAGE, FOURIER, PEGASUS, SAVOR and SOLID) have received institutional research grant support through Brigham and Women’s Hospital from Abbott, Amgen, Anthos Therapeutics, ARCA Biopharma, AstraZeneca, Bayer HealthCare Pharmaceuticals, Daiichi Sankyo, Eisai, Intarcia, Ionis Pharmaceuticals, Janssen Research and Development, MedImmune, Merck, Novartis, Pfizer, Quark Pharmaceuticals, Regeneron Pharmaceuticals, Roche, Siemens Healthcare Diagnostics, Softcell Medical Limited, The Medicines Company, Zora Biosciences, Caremark, Dyrnamix, Esperon, IFM Pharmaceuticals and MyoKardia. The authors who are affiliated with deCODE genetics/Amgen and the authors affiliated with Pfizer declare competing financial interests as employees. The remaining authors declare no competing interests.