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: B.M.P. serves on the steering committee of the Yale Open Data Access Project funded by Johnson & Johnson. C.D.A. receives sponsored research support from Bayer AG and has consulted for ApoPharma. C. Haggerty receives research support from Tempus Labs, outside the scope of the present work. C.M.A. receives sponsored research support from St. Jude, Abbott and Roche. C.R. is supported by a grant from Bayer AG to the Broad Institute focused on the development of therapeutics for cardiovascular disease. C.R. is a full-time employee of GSK as of 1 July 2024. C.T.R. reports research grants through Brigham and Women’s Hospital from Amgen, Anthos, AstraZeneca, Daiichi Sankyo, Janssen, Merck and Novartis and has received honoraria for scientific advisory boards and consulting from Anthos, Bayer, Bristol Myers Squibb, Daiichi Sankyo, Janssen, Pfizer, Regeneron and Sirius. The spouse of C.W. works at Regeneron Pharmaceuticals. D.O.A., D.G., G. Sveinbjornsson, H.A., H.H., K.S., R.B.T. and U.T. are employees of deCODE genetics/Amgen. D.C. has received consultancy fees from Roche Diagnostics and Trimedics, and speaker’s fees from BMS/Pfizer and Servier, all outside of the current work. D.F.F. is a full-time employee of Bayer. E.B. performs uncompensated consultancies and lectures with The Medicines Company. E.-K.C. reports research grants or speaking fees from Abbott, Bayer, BMS/Pfizer, Biosense Webster, Chong Kun Dang, Daewoong Pharmaceutical, Daiichi Sankyo, DeepQure, Dreamtech, Jeil Pharmaceutical, Medtronic, Samjinpharm, Seers Technology and Skylabs. L.-C.W. receives sponsored research support from IBM to the Broad Institute. L.Z. is a full-time employee of Bayer AG. M.E.K. is employed by SYNLAB Holding Deutschland. M.S.S. receives research grant support through Brigham and Women’s Hospital from Abbott, Amgen, Anthos Therapeutics, AstraZeneca, Bayer, Daiichi Sankyo, Eisai, Intarcia, Ionis, Medicines Company, MedImmune, Merck, Novartis, Pfizer and Quark Pharmaceuticals and consults for Althera, Amgen, Anthos Therapeutics, AstraZeneca, Beren Therapeutics, Bristol Myers Squibb, DalCor, Dr. Reddy’s Laboratories, Fibrogen, Intarcia, Merck, Moderna, Novo Nordisk and Silence Therapeutics; additionally, M.S.S. is a member of the TIMI Study Group, which has also received institutional research grant support through Brigham and Women’s Hospital from ARCA Biopharma, Janssen Research and Development, Siemens Healthcare Diagnostics, Softcell Medical Limited, Regeneron, Roche and Zora Biosciences. N.A.M. reports involvement in clinical trials with Amgen, Pfizer, Ionis, Novartis and AstraZeneca without personal fees, payments or increase in salary. P.M.R. has received investigator-initiated research grant support for unrelated projects from NHLBI, Operation Warp Speed, Novartis, Kowa, Amarin and Pfizer and has served as a consultant on unrelated issues to Novo Nordisk, Flame, Agepha, Uppton, Novartis, Jansen, Health Outlook, Civi Biopharm, Alnylam and SOCAR. P.T.E. receives sponsored research support from Bayer AG, Bristol Myers Squibb, Pfizer and Novo Nordisk; he has also served on advisory boards or consulted for Bayer AG. S.A.L. is a full-time employee of Novartis Institutes for BioMedical Research as of 18 July 2022. Previously, S.A.L. received sponsored research support from Bristol Myers Squibb/Pfizer, Bayer, Boehringer Ingelheim, Fitbit, IBM, Medtronic and Premier, and consulted for Bristol Myers Squibb/Pfizer, Bayer, Blackstone Life Sciences and Invitae. S.M.D. receives research support from RenalytixAI and personal consulting fees from Calico Labs, outside the scope of the current research. W.M. reports grants and/or personal fees from Siemens Healthineers, Aegerion Pharmaceuticals, AMGEN, AstraZeneca, Sanofi, Alexion Pharmaceuticals, BASF, Abbott Diagnostics, Numares, Berlin-Chemie, Akzea Therapeutics, Bayer Vital, bestbion dx, Boehringer Ingelheim Pharma, Immundiagnostik, Merck Chemicals, MSD Sharp and Dohme, Novartis Pharma and Olink Proteomics, and other from Synlab Holding Deutschland, all outside the submitted work. A.N. is a consultant for Abbott, Biosrnse Webster, Biotronik, Boston Sci, iRhythm, Field Medical, Pulse Bioselect and Medtronic. S. Khurshid receives sponsored research support from Bayer AG. All other authors declare no competing interests.

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