Koh, Gene Ching Chiek https://orcid.org/0000-0002-3840-4954
Nanda, Arjun Scott https://orcid.org/0000-0001-5014-3104
Rinaldi, Giuseppe https://orcid.org/0000-0002-5650-6049
Boushaki, Soraya
Degasperi, Andrea https://orcid.org/0000-0001-6879-0596
Badja, Cherif https://orcid.org/0000-0003-3736-672X
Pregnall, Andrew Marcel https://orcid.org/0000-0001-9629-0636
Zhao, Salome Jingchen
Chmelova, Lucia
Black, Daniella
Heskin, Laura https://orcid.org/0000-0003-1918-6266
Dias, João https://orcid.org/0000-0002-8451-3537
Young, Jamie
Memari, Yasin
Shooter, Scott
Czarnecki, Jan https://orcid.org/0000-0003-1449-6804
Brown, Matthew Arthur https://orcid.org/0000-0003-0538-8211
Davies, Helen Ruth https://orcid.org/0000-0001-6381-3664
Zou, Xueqing
Nik-Zainal, Serena https://orcid.org/0000-0001-5054-1727
Funding for this research was provided by:
Dr. Josef Steiner Krebsstiftung (Award 2019)
Cancer Research UK (C60100/A23433)
Cancer Research UK (C60100/A25274)
Cancer Research UK (CGCATF-2021/100013)
Cancer Research UK (C60100/A27815)
DH | National Institute for Health Research (NIHR301627)
DH | National Institute for Health Research (BRC-1215-20014)
Basser Gray Foundation
Jeffrey Cheah Foundation
Article History
Received: 14 February 2024
Accepted: 4 March 2025
First Online: 10 April 2025
Competing interests
: A.D., A.S.N., G.C.C.K., G.R., H.R.D., X.Z. and S.N.-Z. hold patents or have submitted applications on clinical algorithms of mutational signatures: MMRDetect (PCT/EP2022/057387), HRDetect (PCT/EP2017/060294), clinical use of signatures (PCT/EP2017/060289), rearrangement signature methods (PCT/EP2017/060279), clinical predictor (PCT/EP2017/060298), hotspots for chromosomal rearrangements (PCT/EP2017/060298), InDel signature methods (PCT/EP2024/077959) and PRRDetect (PCT/EP2024/078030). All other authors declare no competing interests.