Karczewski, Konrad J. https://orcid.org/0000-0003-2878-4671
Gupta, Rahul https://orcid.org/0000-0001-8263-2455
Kanai, Masahiro https://orcid.org/0000-0001-5165-4408
Lu, Wenhan https://orcid.org/0000-0002-3048-9658
Tsuo, Kristin
Wang, Ying https://orcid.org/0000-0001-7808-6279
Walters, Raymond K. https://orcid.org/0000-0001-8422-6530
Turley, Patrick
Callier, Shawneequa https://orcid.org/0000-0002-1007-333X
Shah, Nirav N.
Baya, Nikolas https://orcid.org/0000-0002-4681-374X
Palmer, Duncan S.
Goldstein, Jacqueline I.
Sarma, Gopal
Solomonson, Matthew
Cheng, Nathan
Bryant, Sam https://orcid.org/0009-0001-9891-0488
Churchhouse, Claire https://orcid.org/0000-0003-3140-6452
Cusick, Caroline M.
Poterba, Timothy
Compitello, John
King, Daniel https://orcid.org/0000-0003-3319-9733
Zhou, Wei https://orcid.org/0000-0001-7719-0859
Seed, Cotton
Finucane, Hilary K. https://orcid.org/0000-0003-3864-9828
Daly, Mark J. https://orcid.org/0000-0002-0949-8752
Neale, Benjamin M. https://orcid.org/0000-0003-1513-6077
Atkinson, Elizabeth G. https://orcid.org/0000-0002-6308-776X
Martin, Alicia R. https://orcid.org/0000-0003-0241-3522
Funding for this research was provided by:
U.S. Department of Health & Human Services | NIH | National Institute of Mental Health (R00MH117229)
U.S. Department of Health & Human Services | NIH | National Institute of Mental Health (R37MH107649)
U.S. Department of Health & Human Services | NIH | National Institute of Mental Health (K01MH121659)
Broad Institute (BroadIgnite)
Novo Nordisk Fonden
U.S. Department of Health & Human Services | NIH | National Institute on Aging (F30AG074507)
U.S. Department of Health & Human Services | NIH | National Heart, Lung, and Blood Institute (F31HL167378)
Article History
Received: 13 March 2024
Accepted: 13 August 2025
First Online: 18 September 2025
Competing interests
: K.J.K. is a consultant for Tome Biosciences, AlloDx and Vor Biosciences, and a member of the scientific advisory board of Nurture Genomics. M.J.D is a founder of Maze Therapeutics. B.M.N. is a member of the scientific advisory board at Deep Genomics and Neumora. The other authors declare no competing interests.