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Authors
Li, Haolong https://orcid.org/0000-0002-8628-9698
Melnyk, James E.
Fu, Becky Xu Hua
Shrestha, Raunak https://orcid.org/0000-0002-1144-1413
Zhang, Meng https://orcid.org/0000-0003-1042-6294
Sjöström, Martin https://orcid.org/0000-0002-2629-9966
Feng, Siyu
Anderson, Jasmine A. https://orcid.org/0009-0006-7791-7206
Han, Wanting https://orcid.org/0000-0002-2173-3647
Chesner, Lisa N.
Shin, Hyun Jin
Farsh, Tatyanah https://orcid.org/0009-0000-8058-1033
Suarez, Humberto J.
Nath, Seema https://orcid.org/0000-0002-8362-1165
Chou, Jonathan https://orcid.org/0000-0003-1258-0391
Das, Rajdeep
Egusa, Emily A.
Calvert, Marsha
Kishishita, Audrey
Barpanda, Abhilash
Zhu, Jun
Maheshwari, Ashutosh https://orcid.org/0000-0002-7107-0933
Chen, William S.
Alshalalfa, Mohammed https://orcid.org/0000-0001-8405-3035
Winters, Aidan
Hua, Junjie T.
Liu, Tianyi
Davicioni, Elai
Wiita, Arun P. https://orcid.org/0000-0002-7465-6964
Stohr, Bradley A.
Siddiqui, Javed
Huang, Bo https://orcid.org/0000-0003-1704-4141
Small, Eric J. https://orcid.org/0000-0003-3191-6268
Shokat, Kevan M.
Nelson, Peter S. https://orcid.org/0000-0002-5451-5726
Quigley, David A. https://orcid.org/0000-0002-4726-1473
Wasmuth, Elizabeth V.
Gilbert, Luke A. https://orcid.org/0000-0001-5854-0825
Feng, Felix Y. https://orcid.org/0000-0002-0963-7687
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Article History
Received: 16 September 2024
Accepted: 25 September 2025
First Online: 5 November 2025
Change Date: 17 November 2025
Change Type: Update
Change Details: In the version of this article initially published, a note in the Author contributions indicating that Felix Y. Feng and Luke A. Gilbert (jointly supervising authors) may be listed in either order in any context was missing and is now amended in the HTML and PDF versions of the article.
Competing interests
: H.L., F.Y.F. and L.A.G. have filed a patent application related to targeting PTGES3. M.S. reports personal speaker fees from Astellas and consulting/advisory board for Veracyte/Adelphi Targis. J.C. has grant support from Amgen unrelated to this work. E.D. is an employee of Veracyte, makers of Decipher test. A.P.W. is a member of the Scientific Advisory Board and holds equity stakes in Indapta Therapeutics and Protocol Intelligence, LLC. P.S.N. has served as a paid consultant to Genentech, AstraZeneca, Pfizer and Janssen and received research support from Janssen for work unrelated to the present study. D.A.Q. has received consulting fees from Circle Pharma and Varian. K.M.S. has consulting agreements for the following companies involving cash and/or stock compensation: Black Diamond Therapeutics, BridGene Biosciences, Denali Therapeutics, eFFECTOR Therapeutics, Erasca, Genentech/Roche, Janssen Pharmaceuticals, Kumquat Biosciences, Kura Oncology, Merck, Mitokinin, Petra Pharma, Revolution Medicines, Type6 Therapeutics, Venthera, Wellspring Biosciences (Araxes Pharma). L.A.G. has filed patents on CRISPR functional genomics and is a cofounder of, and consults for, nChroma Bio. F.Y.F. consulted for Astellas, Bayer, Blue Earth Diagnostics, BMS, EMD Serono, Exact Sciences, Foundation Medicine, Janssen Oncology, Myovant, Roivant and Varian, and served on the Scientific Advisory Board for BlueStar Genomics and SerImmune. F.Y.F. has patent applications with Decipher Biosciences, as well as with PFS Genomics/Exact Sciences in breast cancer, all unrelated to this work. The other authors declare no competing interests.
