Reeve, Mary Pat https://orcid.org/0000-0003-1788-2321
Kanai, Masahiro https://orcid.org/0000-0001-5165-4408
Graham, Daniel B. https://orcid.org/0000-0002-8403-8115
Karjalainen, Juha
Luo, Shuang https://orcid.org/0009-0003-8422-4967
Kolosov, Nikita https://orcid.org/0000-0002-2139-6775
Adams, Cameron
Ritari, Jarmo https://orcid.org/0000-0002-3458-9314
Karczewski, Konrad J. https://orcid.org/0000-0003-2878-4671
Kiiskinen, Tuomo https://orcid.org/0000-0002-6306-8227
Jiang, Yu
Fuller, Zachary https://orcid.org/0009-0002-6238-7549
Mehtonen, Juha https://orcid.org/0000-0003-0554-4667
Kurki, Mitja I.
Khan, Zia
,
Daly, Mark J.
Partanen, Jukka https://orcid.org/0000-0001-6681-4734
McCarthy, Mark I.
Artomov, Mykyta https://orcid.org/0000-0001-5282-8764
Palotie, Aarno https://orcid.org/0000-0002-2527-5874
Tuomi, Tiinamaija https://orcid.org/0000-0002-8306-6202
Pirinen, Matti https://orcid.org/0000-0002-1664-1350
Kero, Jukka https://orcid.org/0000-0001-8767-7222
Xavier, Ramnik J.
Daly, Mark J. https://orcid.org/0000-0002-0949-8752
Ripatti, Samuli https://orcid.org/0000-0002-0504-1202
Funding for this research was provided by:
FinnGen
U.S. Department of Health & Human Services | National Institutes of Health (DK43351)
U.S. Department of Health & Human Services | National Institutes of Health (DK135492)
U.S. Department of Health & Human Services | National Institutes of Health (DK43351)
U.S. Department of Health & Human Services | National Institutes of Health (DK135492)
Aging Biology Foundation
Article History
Received: 23 June 2024
Accepted: 22 January 2026
First Online: 26 February 2026
Competing interests
: R.J.X. is co-founder of Convergence Bio, Board Director at MoonLake Immunotherapeutics, consultant to Nestlé and a member of Magnet Biomedicine scientific advisory board. M.J.D. is a founder of Maze Therapeutics. M.I.M. and C.A. are employees of Genentech and holders of Roche stock. Z.K. is a former employee of Genentech and holds Roche stock. K.J.K. is on the Nurture Genomics Scientific Advisory Board. The other authors declare no competing interests.