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Authors
De Coster, Wouter https://orcid.org/0000-0002-5248-8197
Van den Broeck, Marleen
Baker, Matt https://orcid.org/0009-0001-2691-5757
Ghayal, Nikhil B.
Wynants, Sarah https://orcid.org/0000-0003-2376-6722
Batzler, Anthony
Pottier, Cyril https://orcid.org/0000-0002-3049-9346
Alidadiani, Sara
Küçükali, Fahri https://orcid.org/0000-0002-3835-9639
Jenkins, Gregory D. https://orcid.org/0000-0001-6408-6227
Policarpo, Rafaela https://orcid.org/0000-0003-0625-1487
van Blitterswijk, Marka
DeJesus-Hernandez, Mariely
Soto-Beasley, Alexandra I.
Faura, Júlia
Coopman, Elise https://orcid.org/0000-0001-8661-1053
Hutten, Saskia
Mol, Merel O. https://orcid.org/0000-0003-2533-2530
Wallon, David https://orcid.org/0000-0002-2634-7198
Sieben, Anne
Finger, Elizabeth C.
Murray, Melissa E. https://orcid.org/0000-0001-7379-2545
Forrest, Shelley L.
Tartaglia, Maria C. https://orcid.org/0000-0002-5944-8497
Troakes, Claire https://orcid.org/0000-0002-1790-7376
van Rooij, Jeroen G. J. https://orcid.org/0000-0001-9754-073X
Nguyen, Aivi T.
Reichard, R. Ross
Woodman, Natalie L.
Nana, Alissa L. https://orcid.org/0000-0003-3474-8044
Weintraub, Sandra https://orcid.org/0000-0003-2605-5205
Gefen, Tamar
De Vil, Bart https://orcid.org/0000-0003-1924-2029
Bodi, Istvan
Lopez, Oscar L. https://orcid.org/0000-0002-8546-8256
Boluda, Susana https://orcid.org/0000-0002-8045-2706
Belliard, Serge
Lebert, Florence
Marguet, Florent
Mao, Qinwen
Mesulam, Marsel M. https://orcid.org/0000-0001-5731-851X
Boxer, Adam L. https://orcid.org/0000-0002-1215-5064
Vandenbulcke, Mathieu
Suh, EunRan
Schaeverbeke, Jolien
Lambert, Jean-Charles https://orcid.org/0000-0003-0829-7817
Scholz, Sonja W. https://orcid.org/0000-0002-6623-0429
Dalgard, Clifton L. https://orcid.org/0000-0003-2025-8239
Traynor, Bryan J.
Gibbs, Raphael J. https://orcid.org/0000-0002-6985-0658
Schellenberg, Gerard D.
Dormann, Dorothee https://orcid.org/0000-0002-9260-2775
Joris, Geert
De Pooter, Tim https://orcid.org/0000-0002-1097-5464
De Rijk, Peter
D’Hert, Svenn
Van Dongen, Jasper https://orcid.org/0000-0001-5599-0046
van der Zee, Julie
Strazisar, Mojca
Gearing, Marla
Kukar, Thomas https://orcid.org/0000-0002-3750-6262
Flanagan, Margaret
Engelborghs, Sebastiaan https://orcid.org/0000-0003-0304-9785
Ghetti, Bernardino https://orcid.org/0000-0002-1842-8019
Newell, Kathy L. https://orcid.org/0000-0002-1648-7357
King, Andrew
Roeber, Sigrun
Rosen, Howard J.
Spina, Salvatore https://orcid.org/0000-0003-3570-9143
Cras, Patrick https://orcid.org/0000-0002-7265-7429
Ertekin-Taner, Nilüfer https://orcid.org/0000-0003-4436-8889
Wszolek, Zbigniew K. https://orcid.org/0000-0001-5487-1053
Uitti, Ryan J.
Cheshire, William P.
Singer, Wolfgang https://orcid.org/0000-0003-1263-6850
Herms, Jochen https://orcid.org/0000-0002-6201-1042
Josephs, Keith A. https://orcid.org/0000-0003-2930-8634
Whitwell, Jennifer L.
Petersen, Ronald C. https://orcid.org/0000-0002-8178-6601
Pasquier, Florence
Nicolas, Gaël https://orcid.org/0000-0001-9391-7800
Castellani, Rudolph
Glass, Jonathan https://orcid.org/0000-0002-3295-4971
Miller, Bruce L.
Kovacs, Gabor G. https://orcid.org/0000-0003-3841-5511
Rissman, Robert A.
Hiniker, Annie
Deramecourt, Vincent
Ang, Lee-Cyn
Lee-Way, Jin
Van Deerlin, Vivianna M. https://orcid.org/0000-0002-7400-9097
Dugger, Brittany N. https://orcid.org/0000-0003-2141-8855
Thal, Dietmar R. https://orcid.org/0000-0002-1036-1075
Grinberg, Lea T. https://orcid.org/0000-0002-6809-0618
Cruchaga, Carlos https://orcid.org/0000-0002-0276-2899
Arzberger, Thomas
Munoz, David G.
Keith, Julia
Zinman, Lorne
Rogaeva, Ekaterina https://orcid.org/0000-0002-2852-0329
Lee, Edward B. https://orcid.org/0000-0002-4589-1180
Haggarty, Stephen J. https://orcid.org/0000-0002-7872-168X
Ansorge, Olaf https://orcid.org/0000-0003-1825-5434
Husain, Masud https://orcid.org/0000-0002-6850-9255
Halliday, Glenda M. https://orcid.org/0000-0003-0422-8398
Al-Sarraj, Safa
Ross, Owen A. https://orcid.org/0000-0003-4813-756X
Sleegers, Kristel https://orcid.org/0000-0002-0283-2332
Vandenberghe, Rik https://orcid.org/0000-0001-6237-2502
Boeve, Bradley F. https://orcid.org/0000-0002-4153-8187
Graff-Radford, Neill R.
Kofler, Julia
White, Charles L. III https://orcid.org/0000-0002-3870-2804
Lashley, Tammaryn
Neumann, Manuela
Biernacka, Joanna M. https://orcid.org/0000-0001-9350-4440
Seeley, William W. https://orcid.org/0000-0003-1410-2027
Seelaar, Harro https://orcid.org/0000-0003-1989-7527
van Swieten, John C.
Rohrer, Jonathan D.
Dickson, Dennis W. https://orcid.org/0000-0001-7189-7917
Mackenzie, Ian R. A. https://orcid.org/0000-0003-3875-2972
Rademakers, Rosa https://orcid.org/0000-0002-4049-0863
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Article History
Received: 21 February 2025
Accepted: 9 February 2026
First Online: 12 March 2026
Competing interests
: W.D.C. has received free consumables and travel reimbursement from Oxford Nanopore Technologies. W.D.C. and R.R. are inventors on a patent filed concerning diagnostic applications of the GOLGA8A repeat expansion as described in this Article. R.R. received consulting fees from Arkuda Therapeutics. D.R.T. received consulting fees from Muna Therapeutics and collaborated with Novartis Pharma AG (Switzerland), and GE Healthcare (UK). S.E. received consulting fees from Biogen (paid to institution), Eisai (paid to institution), Icometrix (paid to institution), Janssen (paid to institution), Eli Lilly, Novartis (paid to institution) and Remynd (paid to institution). S.E. holds patent EP3452830B1 for an assay for the diagnosis of a neurological disease (licensed to ADX Neurosciences NV & Euroimmun Medizinische Labordiagnostika AG). S.E. is a member of SMB/SAB for EU-H2020 project RECAGE and chair of the DSMB of PRImus-AD (paid to institution). A.L.B. has served as a paid consultant to Alector, Alexion, Arrowhead, Arvinas, Biogen, BMS, Eli Lilly, Janssen, Merck, Neurocrine, Novartis, Oligomerix, Ono, Oscotec, Otsuka, Switch and Voyager. A.L.B. is a scientific cofounder of Neurovanda, and has stock/options in Alector, Arvinas and Neurovanda. S.J.H. serves on the scientific advisory board of Proximity Therapeutics, Psy Therapeutics, Sensorium Therapeutics, 4M Therapeutics, Ilios Therapeutics, Entheos Labs, Birdwood Therapeutics and Manhattan Neuroscience, none of whom was involved in the present study. S.J.H. has also received speaking or consulting fees from Amgen, AstraZeneca, Biogen, Merck, Regenacy Pharmaceuticals, Syros Pharmaceuticals, Juvenescence Life and Souvien Therapeutics, as well as sponsored research or gift funding from AstraZeneca, JW Pharmaceuticals, Lexicon Pharmaceuticals, Vesigen Therapeutics, Compass Pathways, Atai Life Sciences and Stealth Biotherapeutics. R.V.’s institution has clinical trial agreements (R.V. as site PI) with Alector, AviadoBio, BMS, Denali, Eli Lilly, J&J, Merck and UCB. R.V.’s institution has consultancy agreements (R.V. as DSMB or DMC member) with ACImmune and Novartis. Z.K.W. serves as Mayo Clinic site PI on the Amylyx AMX0035-009 project and acts as an external advisory board member for the Savanna Biotherapeutics, Inc., and as a consultant for the BlueRock Therapeutics LP. The other authors declare no competing interests.
