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Plasticity in binding confers selectivity in ligand-induced protein degradation

Crossref DOI link: https://doi.org/10.1038/s41589-018-0055-y

Published Online: 2018-06-11

Published Print: 2018-07

Update policy: https://doi.org/10.1007/springer_crossmark_policy

Authors

Nowak, Radosław P. https://orcid.org/0000-0002-0605-0071
DeAngelo, Stephen L.

Buckley, Dennis

He, Zhixiang

Donovan, Katherine A.

An, Jian

Safaee, Nozhat

Jedrychowski, Mark P.

Ponthier, Charles M.

Ishoey, Mette

Zhang, Tinghu

Mancias, Joseph D.

Gray, Nathanael S. https://orcid.org/0000-0001-5354-7403
Bradner, James E. https://orcid.org/0000-0002-2718-4415
Fischer, Eric S. https://orcid.org/0000-0001-7337-6306
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Article History

Received: 4 August 2017

Accepted: 13 March 2018

First Online: 11 June 2018

Competing interests

: E.S.F. is a member of the scientific advisory board of C4 Therapeutics and is a consultant to Novartis Pharmaceuticals. N.S.G. is a founder and scientific advisory board member of C4 Therapeutics. J.E.B. is an executive and shareholder of Novartis Pharmaceuticals.