Yin, Zhuoran
Rosenzweig, Neta
Kleemann, Kilian L.
Zhang, Xiaoming
Brandão, Wesley
Margeta, Milica A.
Schroeder, Caitlin
Sivanathan, Kisha N.
Silveira, Sebastian
Gauthier, Christian
Mallah, Dania
Pitts, Kristen M. http://orcid.org/0000-0001-7049-0883
Durao, Ana
Herron, Shawn
Shorey, Hannah
Cheng, Yiran
Barry, Jen-Li
Krishnan, Rajesh K.
Wakelin, Sam
Rhee, Jared
Yung, Anthony http://orcid.org/0000-0002-1338-9401
Aronchik, Michael
Wang, Chao
Jain, Nimansha
Bao, Xin
Gerrits, Emma
Brouwer, Nieske
Deik, Amy http://orcid.org/0000-0002-9687-0953
Tenen, Daniel G. http://orcid.org/0000-0002-6423-3888
Ikezu, Tsuneya http://orcid.org/0000-0002-3979-8596
Santander, Nicolas G. http://orcid.org/0000-0001-8919-833X
McKinsey, Gabriel L.
Baufeld, Caroline
Sheppard, Dean http://orcid.org/0000-0002-6277-2036
Krasemann, Susanne http://orcid.org/0000-0001-8795-818X
Nowarski, Roni
Eggen, Bart J. L. http://orcid.org/0000-0001-8941-0353
Clish, Clary http://orcid.org/0000-0001-8259-9245
Tanzi, Rudolph E. http://orcid.org/0000-0002-7032-1454
Madore, Charlotte
Arnold, Thomas D.
Holtzman, David M.
Butovsky, Oleg http://orcid.org/0000-0003-0186-8867
Funding for this research was provided by:
U.S. Department of Health & Human Services | NIH | National Institute on Aging (R01AG051812, R01AG054672, R01AG075509, R21AG076982, R01AG080992)
U.S. Department of Health & Human Services | NIH | National Eye Institute (R01EY027921, K12EY016335, K08 EY030160)
U.S. Department of Health & Human Services | NIH | National Institute of Neurological Disorders and Stroke (R01NS088137, R21NS101673, RF1NS090934)
BrightFocus Foundation (2020A016806)
Cure Alzheimer’s Fund
U.S. Department of Health & Human Services | NIH | National Institute of General Medical Sciences (R01GM132668)
Nancy Davis Foundation for Multiple Sclerosis
Alzheimer’s Association (AARF-21-846786)
National Multiple Sclerosis Society (FG-2108-38372)
U.S. Department of Defense (MS210257)
Research to Prevent Blindness
Glaucoma Research Foundation
Article History
Received: 3 November 2022
Accepted: 15 August 2023
First Online: 25 September 2023
Competing interests
: O.B., Z.Y. and N.R. are inventors of a patent licensed by Brigham and Women’s Hospital for use of LGALS3 for treatment of neurodegenerative diseases. O.B., Z.Y., N.R., X.Z., T.D.A. and D.S. are inventors for a patent licensed by Brigham and Women’s Hospital and University of California, San Francisco, for use of an ITGB8 blocker for treatment of neurodegenerative diseases. O.B. has a collaboration with GSK and Regulus Therapeutics, receives research funding from Sanofi and GSK and receives honoraria for lectures and consultancy from UCB, Camp4, Ono Pharma USA and General Biophysics. D.M.H. is an inventor on a patent licensed by Washington University to C2N Diagnostics on the therapeutic use of antibodies to tau and on a patent licensed to NextCure on antibodies to APOE. D.M.H. cofounded and is on the scientific advisory board of C2N Diagnostics. D.M.H. is on the scientific advisory board of Denali, Genentech and Cajal Neuroscience and consults for Alector. All other authors have no competing interests.