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Single-cell atlas of human liver and blood immune cells across fatty liver disease stages reveals distinct signatures linked to liver dysfunction and fibrogenesis

Crossref DOI link: https://doi.org/10.1038/s41590-025-02255-y

Published Online: 2025-08-29

Published Print: 2025-09

Update policy: https://doi.org/10.1007/springer_crossmark_policy

Authors

Martin, Owen P. https://orcid.org/0009-0002-5014-0039
Wallace, Michael S. https://orcid.org/0000-0002-9679-6546
Oetheimer, Christopher

Patel, Hailey B.

Butler, Michael D. https://orcid.org/0009-0005-2210-8922
Wong, Lai Ping

Huang, Pinzhu https://orcid.org/0000-0002-8339-9701
Elbaz, Joshua

Costentin, Charlotte

Salloum, Shadi

Reinus, Zoe

Obinelo, Adaeze

Kim, Ulandt

Shroff, Stuti https://orcid.org/0000-0002-1674-2557
Corey, Kathleen E.

Popov, Yury V.

Charles, Edgar D.

Sadreyev, Ruslan I.

Chung, Raymond T.

Alatrakchi, Nadia https://orcid.org/0000-0001-7600-564X
Funding

Funding for this research was provided by:

U.S. Department of Health & Human Services | NIH | National Institute of Diabetes and Digestive and Kidney Diseases (R56DK134251, R01DK098079)

Bristol-Myers Squibb
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Text and Data Mining valid from 2025-08-29

Version of Record valid from 2025-08-29
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Article History

Received: 22 February 2024

Accepted: 16 July 2025

First Online: 29 August 2025

Competing interests

: E.D.C. was formerly employed by Bristol Myers Squibb. R.T.C. received research grants to the institution from Abbvie, Gilead Sciences, Merck, Boehringer, Janssen and BMS. N.A. received a research grant to the institution from Boehringer for unrelated work. The other authors declare no competing interests.

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