Document is current

Article History

Received: 2 June 2021

Accepted: 13 September 2021

First Online: 6 December 2021

Competing interests

: The authors declare the following competing interests: D.J.D. has served as a consultant for Amgen, Agios, Autolus, Blueprint Medicines Corporation, Forty-Seven, Incyte Corporation, Jazz, Novartis, Pfizer, Shire and Takeda, and received research funding from AbbVie, GlycoMimetics and Novartis. D.H.R. is a paid consultant for and has received research support from Blueprint Medicines Corporation, is a member of the RACs for the EXPLORER and PATHFINDER studies and has received honoraria from Novartis for educational events and consultancy. T.I.G. is a paid consultant and has served as a study steering group member for Blueprint Medicines Corporation, and is employed by ARUP Laboratories/University of Utah, which received funding from Blueprint Medicines Corporation. W.A.R. has received research funding from Blueprint Medicines Corporation. A.T.Q. has no competing interests to declare. M.W.D. received research support from Blueprint Medicines Corporation and Novartis. P.B. has received research honoraria/consulting fees from Blueprint Medicines Corporation, Incyte Corporation, Celgene Corporation (now BMS), CTI BioPharma, Kartos Therapeutics and Sierra Oncology, and research support from Blueprint Medicines Corporation, Celgene Corporation (now BMS), Kartos Therapeutics, Incyte Corporation, Constellation Pharmaceuticals, CTI BioPharma, Astellas Pharmaceuticals, Pfizer, Inc., NS Pharma and Promedior. E.O.H. has received research support and has served on a Data and Safety Monitoring Board for Blueprint Medicines Corporation, has received research support from Novartis Pharmaceuticals and Tmunity Therapeutics, and serves on the hematology exam committee for the American Board of Internal Medicine. E.F.W. has received research support for conduct of clinical studies from Blueprint Medicines Corporation, Samus Therapeutics and Incyte Corporation. H.-P.H. has served as a consultant for Novartis and Blueprint Medicines Corporation. M.T., O.S.-K. and E.K.E. are shareholders and former employees of Blueprint Medicines Corporation. H-M.L. and B.G.M. are both current employees and shareholders of Blueprint Medicines Corporation. S.V. declares research support for the conduct of clinical studies from Incyte, Roche, NS Pharma, Celgene, Gilead, Promedior, CTI BioPharma, AbbVie, Blueprint Medicines Corporation, Novartis, Sierra Oncology, PharmaEssentia, Constellation Pharmaceuticals, Ital Pharma, Protagonist and Kartos Therapeutics. M.W.D. is a paid consultant for Fusion Pharma, Takeda, Medscape, Novartis, Incyte, Sangamo, SPARC, Pfizer and DisperSol, has received research support from Blueprint Medicines Corporation and SPARC, and has served on study management committees for clinical studies sponsored by Pfizer, Takeda and Blueprint Medicines Corporation. J.G. is a paid consultant for, and has received research funding from, Blueprint Medicines Corporation, Deciphera, Incyte and Kartos Therapeutics, and has served as chair of the RAC for Blueprint Medicines Corporation’ phase 1 EXPLORER study, and for the phase 2 PATHFINDER study, and as co-chair for the Deciphera Study Steering Committee for ripretinib in AdvSM and chair of the Central Response Review Committee for the phase 2 study of bezuclastinib in AdvSM.