Document is current

Article History

Received: 2 June 2021

Accepted: 13 September 2021

First Online: 6 December 2021

Competing interests

: J.G. is the Chair of the Study Steering Committee of the PATHFINDER trial, Chair of the Response and Adjudication Committee for the EXPLORER trial, has received research funding, served on advisory boards and received honoraria and funding to cover travel expenses from Blueprint Medicines Corporation. He has received research funding, is the co-chair of the phase 2 trial of ripretinib in AdvSM Study Steering Committee and has honoraria for these roles and serves on advisory boards for Deciphera. He also serves as Chair of the Central Response Review Committee for the phase 2 trial of bezuclastinib in AdvSM. A.R. has been a clinical advisory board/study steering committee member (PATHFINDER trial) and received honoraria and funding to cover travel expenses from Blueprint Medicines Corporation. He has received advisory board fees, speaking fees and travel support from Novartis, Deciphera, Incyte, Celgene, AOP Pharmaceuticals and AbbVie, and research support from Novartis. D.H.R. has been a clinical advisory board/study steering committee member (EXPLORER and PATHFINDER studies) for Blueprint Medicines Corporation, and was involved with educational events and advisory boards for Novartis. M.W.D. has received honorarium fees from Blueprint Medicines Corporation, Incyte, Medscape, Sangamo and Takeda; consultancy fees from Blueprint Medicines Corporation, DisperSol, Fusion Pharma, Novartis and Sangamo; and research funding from Blueprint Medicines Corporation, Incyte, Leukemia & Lymphoma Society, Novartis, Pfizer, SPARC and Takeda. He is part of Study Steering Committees for Blueprint Medicines Corporation and Takeda and is a case author for Medscape. T.I.G. has been a clinical advisory board/study steering committee member (EXPLORER and PATHFINDER studies) and has received consulting fees from Blueprint Medicines Corporation, Celgene and Incyte. J.P. has received honorarium fees from Apellis, Blueprint Medicines Corporation, BMS, Grünenthal, MSD, Sobi and F. Hoffmann-La Roche. He has served on the speaker’s bureau of Alexion, Boehringer Ingelheim, Novartis, Pfizer and Chugai. A.M.V. has participated in speakers’ bureaux for AOP, BMS-Celgene, Novartis and Shire, and on advisory boards for AbbVie, BMS-Celgene, CTI BioPharma, Incyte and Novartis. U.P. received research funding from BMS, Amgen, Novartis, Curis and BerGenBio. I.A.-T. has served on advisory boards for, and received honoraria and research funding from, Blueprint Medicines Corporation and has participated in educational events for Novartis. A.M. has received honorarium fees from Takeda, Pfizer, Novo Nordisk, Behring, AbbVie, Novartis, Cilag, Janssen and Bayer. O.H. received research funding from AB Science, BMS/Celgene, Alexion, Novartis and Inatherys, consulted for AB Science and is a shareholder for AB Science. I.D. has received advisory board fees from Novartis. E.O.H. has received research support (institution) from Blueprint Medicines Corporation, Samus Therapeutics and Novartis Oncology. She serves on a data safety monitoring committee for Blueprint Medicines Corporation and is a member of the hematology exam committee for the American Board of Internal Medicine. L.K.H. has received research support (institution) from Gilead Sciences. L.S. has no disclosures. R.M. has been a consultant for Novartis, Sierra Oncology and La Jolla Pharma and has received research support from Celgene, Incyte, AbbVie, Samus, Genentech, Promedior and CTI BioPharma. P.B. has received research support from Incyte, Celgene (now BMS), CTI BioPharma, Kartos, Blueprint Medicines Corporation, Constellation, Astellas, Pfizer, NS Pharma and Promedior; and honoraria from Incyte, Celgene (now BMS), CTI BioPharma, Kartos and Blueprint Medicines Corporation. K.M.P. has participated on advisory boards for CTI BioPharma, PharmaEssentia and Kura Oncology. M.L.H. has received research funding from Blueprint Medicines Corporation, BMS, CTI BioPharma, Deciphera, Incyte, Novartis and Sierra Oncology; and consulting fees from AbbVie, CTI BioPharma, Novartis, Blueprint Medicines Corporation and Partner Therapeutics. S.T.O. has been a consultant for Gilead Sciences, Novartis, Kartos Therapeutics, CTI BioPharma, Celgene/Bristol Myers Squibb, Disc Medicine, Blueprint Medicines Corporation, PharmaEssentia, Constellation and Incyte. J.S., H.-M.L. and B.G.M. are employees and/or equity holders of Blueprint Medicines Corporation. D.J.D. has been a clinical advisory board/study steering committee member (EXPLORER and PATHFINDER studies) for Blueprint Medicines Corporation. He has served as a consultant for Amgen, Agios, Autolus, Forty-Seven, Incyte Corporation, Jazz, Novartis, Pfizer, Shire and Takeda; and has received research funding from AbbVie, GlycoMimetics and Novartis.