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Article History

Received: 18 December 2020

Accepted: 13 October 2021

First Online: 10 December 2021

Competing interests

: T.P.: grant support, paid to Barts Cancer Institute, and consulting fees from Astellas, Bristol Myers Squibb, Eisai, Exelixis, Johnson & Johnson Healthcare Systems, the healthcare business of Merck KGaA, Darmstadt, Germany, Merck & Co., Kenilworth, NJ, Novartis and Seattle Genetics; grant support, paid to Barts Cancer Institute, and consulting fees and travel support from AstraZeneca; grant support, paid to Barts Cancer Institute, consulting fees and travel support from F. Hoffmann-La Roche, Ipsen Biopharmaceuticals and Pfizer; and consulting fees from Incyte. S.S.S.: advisory board fees from AstraZeneca, Bristol Myers Squibb, F. Hoffmann-La Roche and the healthcare business of Merck KGaA, Darmstadt, Germany, Merck & Co., Kenilworth, NJ; and grant support, paid to Princess Margaret Cancer Centre, advisory board fees and lecture fees from Pfizer. Y.L.: advisory board fees and travel support from Astellas, Bristol Myers Squibb, Janssen Biotech and Seattle Genetics; advisory board fees, lecture fees and travel support from AstraZeneca and Merck & Co., Kenilworth, NJ; advisory board fees and lecture fees from Pfizer; and advisory board fees from Sanofi. J.B.: advisory board fees and lecture fees from AstraZeneca and Merck & Co., Kenilworth, NJ; lecture fees from Bristol Myers Squibb; advisory board fees from Genentech, Janssen Global Services and Pierre Fabre; advisory board fees and travel support from Pfizer; and grant support from Takeda Oncology. X.M.: employee and stockholder of Pfizer. K.A.C.: employee and stockholder of Pfizer. J.P.: employee and stockholder of Pfizer. C.N.S.: consulting fees from Astellas, AstraZeneca, Genentech, Incyte, the healthcare business of Merck KGaA, Darmstadt, Germany, Merck & Co., Kenilworth, NJ, Pfizer, Sanofi, Genzyme, Immunomedics, Bristol Myers Squibb, Foundation Medicine, Medscape and UroToday. D.P.: grant support, paid to Yale University, from Advanced Accelerator Applications, Agensys, Astellas, AstraZeneca, Bayer, BioXcel Therapeutics, Bristol Myers Squibb, Clovis Oncology, Eisai, Eli Lilly, Endocyte, Genentech, Gilead Sciences, Innocrin, MedImmune, Medivation, the healthcare business of Merck KGaA, Darmstadt, Germany, Mirati, Novartis, Pfizer, Progenics, Replimune, Roche, Sanofi Aventis and Seattle Genetics; and consulting fees from Advanced Accelerator Applications, Amgen, Astellas, AstraZeneca, Bayer, Bicycle Therapeutics, Boehringer Ingelheim, Bristol Myers Squibb, Clovis Oncology, Eli Lilly, Exelixis, Gilead Sciences, Incyte, Ipsen, Janssen, Mirati, Monopteros, Pfizer, Pharmacyclics, Regeneron, Roche, Seattle Genetics and Urogen. R.T.: nothing to disclose. L.M.D.: consulting fees from Janssen, Astellas, Bayer and Pfizer; and travel support from Janssen and Pfizer. C.A.-F.: consulting fees from AstraZenenca, Pfizer, Ipsen and Boehringer Ingelheim; and travel fees from Roche, Pfizer and Astellas. M.A.: consulting fees from Astellas, Bristol Myers Squibb, the healthcare business of Merck KGaA, Darmstadt, Germany, Merck & Co., Kenilworth, NJ, Novartis, Pierre Fabre, Pfizer and Sanofi; grant support, paid to Maastricht University Medical Centre, from Pfizer; and travel support from Sanofi. A.d.P.: employee and stockholder of Pfizer. P.G.: consulting fees from AstraZeneca, Astellas, Bayer, Bristol Myers Squibb, Clovis Oncology, Dyania Health, Driver, Exelixis, Foundation Medicine, Genentech/Roche, Genzyme, Gilead/Immunomedics, GlaxoSmithKline, Guardant Health, Heron Therapeutics, Infinity Pharmaceuticals, Janssen, the healthcare business of Merck KGaA, Darmstadt, Germany, Merck & Co., Kenilworth, NJ, Mirati Therapeutics, Pfizer, Regeneron, Seattle Genetics, 4D Pharma PLC, UroGen, and QED Therapeutics; research funding, paid to his institution, from the healthcare business of Merck KGaA, Darmstadt, Germany, Merck & Co., Kenilworth, NJ, Pfizer, Clovis Oncology, Bavarian Nordic, Immunomedics, Debiopharm, Bristol Myers Squibb, QED Therapeutics, GlaxoSmithKline, Mirati Therapeutics and Kure It Cancer Research. C.B.D.: employee and stockholder of Pfizer.